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Controversial stem cell paper retracted as cells 'never existed'

9 June 2014
Appeared in BioNews 757

The lead author of a controversial study describing a new type of stem cell - stimulus-triggered acquisition pluripotency (STAP) cells - has agreed to retract two research papers published in the journal Nature in January 2014 (reported in BioNews 740).

Dr Haruko Obokata, of the RIKEN Institute in Japan, is said to have agreed to retract the papers after new evidence emerged about the authenticity STAP cells, according to the Japan Daily Press.

A new genetic test analysis of the STAP stem cell lines found that the cells were derived from different strains of mice than stated in the research publications, suggesting contamination. An independent investigation by researchers at RIKEN and Yamanashi University found that the STAP stem cell lines were derived from a combination of B6 and CD1 mouse strains, rather than the F1 mouse strain as described in the original study.

In a press interview, Dr Takaho Endo from RIKEN, who was involved in the investigation, said: 'it is quite unlikely that this happens as a result of an accident or mistake'.

Dr Obokata was found guilty of research misconduct in May 2014 in relation to the two STAP papers published in Nature (reported in BioNews 749). The findings first came under investigation by RIKEN after bloggers questioned whether some of the images presented were duplicated or manipulated (reported in BioNews 743). The institute concluded that Dr Obokata had fabricated some of the images presented in the research papers, duplicated some images and reused images from her doctoral thesis in a way that was deliberately misleading.

Dr Obokata apologised and had previously stood by the research and STAP cells, but has now agreed to retract both papers. All study co-authors must agree before Nature will consider a retraction. Senior author Professor Charles Vacanti, from Harvard Medical School and Brigham and Women's Hospital, is now said to support the retraction, having initially defended the research papers, reports Nature News.

The new genetic analysis findings call into question the existence of STAP cells. The original research concluded that exposure of mature mouse blood cells to stress such as acid or physical pressure results in cell reprogramming, generating pluripotency cells with characteristics similar to embryonic stem cells. To date, no other researchers have been able to replicate the findings of Dr Obokato and her team.

Besieged Obokata agrees to retract primary STAP cells paper
The Japan Times |  4 June 2014
Final Straw for STAP?
The Scientist |  4 June 2014
Genetic tests suggest STAP stem cells ‘never existed’
Nature News Blog |  3 June 2014
Obokata agrees to pull main STAP cell article
Asahi Shimbun |  4 June 2014
1 September 2014 - by Dr Nicoletta Charolidi 
Efforts to replicate the STAP cell findings have not been successful so far, the RIKEN Institute has reported...
11 August 2014 - by Antony Blackburn-Starza 
A leading Japanese scientist who was embroiled in the STAP cell controversy has been found dead in an apparent suicide....
7 July 2014 - by Antony Blackburn-Starza 
Nature has retracted two papers published in January on the creation of so-called 'STAP' cells, after all co-authors agreed to the retractions....
7 July 2014 - by Dr Dusko Ilic 
Two papers published back to back in Nature took our breath away earlier this year, but the research community soon became sceptical and the published work was subjected to unprecedented scrutiny. How is it possible that something like this could happen?...
16 June 2014 - by Dr Greg Ball 
The controversy surrounding the creation of so-called STAP cells continues with a report recommending the closure of the RIKEN Centre for Developmental Biology, the institute where the research was carried out...
12 May 2014 - by Purvi Shah 
Japan's RIKEN Center has announced that an appeal by stem-cell scientist, Dr Haruko Obokata, found guilty of research misconduct in relation to her claims of converting blood cells to stem cells using an 'acid bath', has been rejected...
14 April 2014 - by Dr Greg Ball 
Dr Haruko Obokata, the lead author of two controversial stem cell papers that reported discovery of so-called STAP cells, has apologised for errors in her work...
7 April 2014 - by Dr Greg Ball 
An investigation has found that the lead author of the widely reported 'breakthrough' stem cell papers is guilty of misconduct...
24 February 2014 - by Patricia Cassidy 
Research published in Nature that described a simple way to generate stem cells is now under investigation after blog posts called its findings into question...
3 February 2014 - by Dr Lanay Griessner 
Stem cells have been created from mouse blood cells using a simple and quick method described as 'remarkable' by experts...
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