Page URL:

Fertility preservation after cancer diagnosis

11 June 2012
By Valerie Peddie
Honorary research fellow, University of Aberdeen School of Medicine
Appeared in BioNews 660
A recently published qualitative study (1) on the perceptions of young people diagnosed with cancer and their future fertility, for which I was the lead author, prompted media attention in the context of male and female patients receiving different information with regard to fertility preservation.

The Royal College of Obstetricians and Gynaecologists, the British Fertility Society, and the American Society for Reproductive Medicine all support the concept of providing every patient of reproductive age with accurate information about the potential risk of impaired fertility after treatment for cancer, irrespective of whether local facilities for gamete cryopreservation exist. In reality, the immediate emphasis is often on treatment, with little time available to discuss future fertility or options for fertility preservation. Logistical barriers and timely patient referral (including coordination of care between specialties) can also limit patient access to the available options (2).

Preservation options for young women and girls who require urgent cancer treatment, have no male partner or are unable to undergo hormonal intervention are clearly limited in the best of circumstances. Still, it remains important for clinicians to consider the effects of chemo and/or radiotherapy on future reproductive function.

Our study shows that significant gaps in the information provided to young women diagnosed with cancer exist and suggests a need for an early appointment with a fertility expert.

Previous research (3) considered 'the deep human desire to have a child' a challenge for patients and clinicians alike and highlighted the fact that concerns about fertility are similar in both genders but opportunities for intervention very different. Bury's theory (4) of 'biographical disruption' (the loss of the capacity to anticipate and package one's life according to a pre-existing template) can be experienced as a devastating rupture, which impacts negatively on an individual's psychological health and well-being (5).

In our study, the tension between the clinical (cancer diagnosis and emphasis regarding the urgency of treatment) and the social (in respect of relationship formation, consolidation and reproductive decision-making) was thrown into sharp focus. Young adults (in particular men) who might be in a relatively new relationship were suddenly faced with having conversations about their reproductive intentions and found themselves subject to 'biographical acceleration' as they were plunged into hypothetical and sometimes actual decision-making as a couple (5).

Estimates suggest that in 2010, one in 715 people in the UK had survived cancer during childhood. Healthcare professionals note a growing emphasis on 'quality of life' after cancer survival (6). Yet a recent survey of more than 300 health care practitioners conducted by researchers at the Royal Free Hampstead NHS Trust, found that fewer than 40 percent considered discussion of future fertility in women diagnosed with breast cancer (7).

Such information is indeed timely given the partial review of the National Institute for Health and Clinical Excellence (NICE) guideline on fertility (8) has just been released for consultation. Although the guideline development group considered the effects of cancer on fertility in the review process, its remit was 'to examine the effectiveness of different methods of cryopreservation' in the context of preservation of fertility before starting chemo or radiotherapy. It was disappointing that 'quality of life' and associated fertility did not merit discussion and no qualitative studies were included in the review (9).

Professor Jane Noyes, the lead convener of the Cochrane Qualitative Research Methods Group has noted a growing appreciation for qualitative studies, alongside quantitative research, as part of the evidence base for commissioners and policy makers (10). Indeed the Cochrane Collaboration now acknowledges the limitation imposed on policy and decision-making by using quantitative data alone.

My co-authors and I do not advocate 'cryopreservation for all' and have the utmost respect for the clinician's role in deciding patients' suitability for fertility preservation but we do uphold a multidisciplinary approach to the management of this unique patient group. Such collaboration should permit discussion (considering the qualitative evidence available) and a range of options for patients. To this end, we welcome the recommendations put forward by the NICE review guideline development group.

There is no doubt that the multidisciplinary response has been in accordance with the professional 'guidance' mentioned earlier, however clinicians appear to be unclear as to what constitutes 'experimental' techniques for fertility preservation. The field of 'Onco-Fertility', as it is known, is in a stronger position now than it has been for over a decade. Perhaps we need to consider the three major gaps highlighted by the 'Onco-Fertility Consortium' (2) in the US: surviving cancer (and the importance of expectation of reproductive function and family); science and emerging technology (working together to improve its efficacy); and resource allocation (in supporting a collaborative 'National Business Case' for utility).

Through collaboration, we can educate young people diagnosed with cancer to formulate their own opinions about the science, often portrayed as controversial.

01) Peddie VL et al. Factors affecting decision making about fertility preservation after cancer diagnosis: a qualitative study
BJOG: An International Journal of Obstetrics & Gynaecology |  30 May 2012
02) Woodruff KS. The Onco Fertility Consortium – addressing fertility in young people diagnosed with cancer
Nature Reviews Clinical Oncology |  1 August 2010
03) Jeruss, JS and Woodruff TK. Preservation of Fertility in Patients with Cancer
New England Journal of Medicine |  26 February 2009
04) Bury M. Chronic Illness as Biographical Disruption
Sociology of Health and Illness |  1 July 1982
05) Barbour, S. The Biographical Turn and the ‘Sociolization’ of Medicine
Medical Sociology Online |  1 November 2011
06) Wallace WHB, Anderson RA and Irvine S. Fertility preservation for young patients with cancer: who is at risk and what can be offered?
The Lancet Oncology |  1 April 2005
07) Breast cancer patients lack adequate fertility preservation advice
National Cancer Research Institute |  7 November 2011
08) Fertility: Assessment and treatment for people with fertility problems
NICE |  2004
09) Fertility (update): Guideline Consultation
NICE |  2012
10) Noyes J. Never mind the qualitative feel the depth! The evolving role of qualitative research in Cochrane intervention reviews
Journal of Research in Nursing |  4 October 2010
24 November 2014 - by Isobel Steer 
The majority of young breast cancer patients are not being referred for treatment which could preserve their fertility after chemotherapy, says a UK charity...
14 April 2014 - by Cait McDonagh 
A Crohn's disease patient is challenging a decision to refuse her funding for her eggs to be cryopreserved before she undergoes a bone marrow transplant and chemotherapy...
29 July 2013 - by Dr James Heather 
Despite treatment for childhood cancer causing an increased risk of infertility, most women still manage to conceive, research has shown...
3 December 2012 - by Dr Lucy Spain 
A former cancer patient has become the first woman in Australia to become pregnant following the pioneering procedure of ovarian tissue transplantation...
26 November 2012 - by Dr Rosie Morley 
An Argentinian woman has given birth to twins after IVF treatment using eggs that had been frozen for 12 years...
15 May 2012 - by Dr Vardit Ravitsky and Professor David Heyd 
Sex reassignment is an intricate and sensitive physiological, psychological, and social process that usually entails the loss of reproductive capacity. Reproductive technology can prevent this loss, but should it be used for that purpose? A recent case in Israel raises this question...
3 November 2008 - by Dr Peter Hollands 
The recent correspondence on egg vitrification in BioNews (1,2), prompts me to wonder if the pioneering research spirit that started the IVF industry sometimes gets a little carried away in the reality of patient care. At the start of the IVF industry the players were researchers and academics, and new...
10 July 2008 - by Dr Charlotte Maden 
A group of German researchers has reported a new technique that will increase the chances of preserving fertility in women having treatment for cancer. The findings, presented at the annual meeting of the European Society of Human Reproduction and Embryology in Barcelona, offer new hope to female...
2 December 2002 - by BioNews 
Two new research studies have been published in the journal Human Reproduction which 'bring new hope of preserving fertility for boys who face sterility after cancer treatment'. In the first study, a Japanese team report that they have enabled mice to be born from frozen immature testicular tissue taken from...
to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions

Syndicate this story - click here to enquire about using this story.