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Italian reproduction law increases multiple pregnancies

16 July 2007
Appeared in BioNews 416

The Italian health minister, Livia Turco, has publicised an official report examining data on assisted reproduction following the introduction of a new restrictive law in 2004. The study has found that a reduction in the success rate of procedures and an increase in multiple pregnancies have been the result of the new rules.

The law was approved by the then right of centre government, and prescribed that only three embryos could be created in each IVF cycle, that embryos could not be frozen, and that all embryos must be implanted in the womb, as well as banning PGD and the use of donated gametes.

The results of the study show that in the years between 2003 and 2005, since the introduction of the legislation, centres offering assisted reproduction found a 14.5 per cent decrease in the number of pregnancies for every 100 eggs extracted. There was also a decrease in the number of pregnancies per embryo transfer, from 27.6 per cent in 2003 to 24.5 per cent in 2005.

In addition, the rate of negative outcomes rose from 23.4 per cent to 26.4 per cent. The number of multiple births increased from 22.7 per cent to 24.3 per cent, due to the usual practice of fertilising three embryos, which then must be implanted in the womb.

Dr Giulia Scaravelli, head of the registry at the Instituto Superiore di Sanita, stated that although the findings were significant, the scientific value of the report was not totally satisfactory, due to the lack of follow up data. Due to Italian privacy laws, for example, the researchers were unable to find out how many women repeat cycles of IVF before becoming pregnant or giving up. Dr Scaravelli explained that they would attempt to overcome the limits of the study by asking patients to complete a voluntary survey on each cycle. She stated that 'this way we also hope we'll have a much better follow-up on the outcome of the pregnancies, so that we'll have a less approximate measure of the live birth rates'.

One effect of the restrictive legislation is that couples have travelled abroad to seek IVF treatment or PGD. In 2006, the Reproductive Tourism Observatory estimated that the number of couples seeking treatment abroad had increased four-fold in the wake of the introduction of the measures. However, legal challenges to the ban on PGD in the Italian courts have so far failed.

Restrictive law on reproduction increases multiple pregnancies
The British Medical Journal |  14 July 2007
14 December 2009 - by Antony Starza-Allen 
A group of Italian scientists have lost an appeal to challenge a research funding call that excludes embryonic stem celln (ES cell) research even though the technique is lawful in the country, Nature reports. The Italian health ministry put together an expert committee to produce a set of proposals to attract funding, after the previous stem cell research fund was marred in controversy following allegations that funds were being distributed in a non-transparent and arbitrary manner. ..
22 September 2008 - by Sarah Pritchard 
A report has indicated for the first time the cost faced by the UK's National Health Service (NHS) as it copes with multiple births resulting from IVF patients treated abroad. New research undertaken by the Fetal Medicine Unit at University College London Hospital (UCLH) makes a link...
11 December 2006 - by Dr Jess Buxton 
Thousands of Italians are being forced to travel abroad for assisted reproduction or preimplantation genetic diagnosis (PGD) treatment, because of Italy's highly restrictive legislation. The results of a new survey carried out by the Reproductive Tourism Observatory show that the number of couples travelling to other...
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