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UK scientists apply for 'three parent embryo' licence

21 October 2004
By BioNews
Appeared in BioNews 281

Scientists at the University of Newcastle are applying for a licence to create embryos with 'three parents', in order to prevent genetic conditions caused by faults in the 'powerhouses' of the cell. Doug Turnbull and Mary Herbert have submitted an application to the UK's Human Fertilisation and Embryology Authority, which will be considered over the next few weeks. They want to remove the nucleus from a fertilised egg, and transplant it into another, unfertilised egg that has had its own nucleus removed. In this way, they hope to replace the fertilised egg's faulty mitochondria - tiny structures found in a cell that are responsible for energy production.

Mitochondria contain around 35 genes, and several inherited diseases are caused by mutations in this DNA. The researchers hope that by transferring the nucleus of a cell that has faulty mitochondria to a healthy egg cell, they will be able to develop a new treatment for these mitochondrial disorders. But critics are alarmed by the move, since it would result in embryos that have a tiny amount of DNA from the egg donor, as well as its own parents. 'By creating a child with three genetic parents, these scientists are taking the first step towards genetic engineering of human beings', said David King of Human Genetics Alert. However, Leon Kass, chairman of the US President's Council on Bioethics, says this label is a red herring. 'I think that it is for my own tastes stretching the idea of genetic engineering', he told New Scientist magazine, but added that he would 'be inclined to be cautious' in this area of work.

Herbert says that the team will not apply for a licence to use the technique to treat patients until 'we can demonstrate absence of known harmful effects'. She also said that they respected the views of people who feel that no research should be carried out on human embryos, but added that 'it could be argued that there is a moral obligation to reduce suffering in children at risk of inheriting mitochondrial disease'. Last year, a group of researchers based in China reported that they had used the technique to try and help a woman undergoing in IVF, whose fertilised eggs would not develop past the two-cell stage. However, none of the embryos survived beyond the 29th week of pregnancy, for reasons apparently unrelated to the method of their creation.

Meanwhile, researchers in Taiwan say they have found a way to improve the chances of IVF success for some women, by using mitochondria taken from their own cells. The technique, presented at the American Society for Reproductive Medicine in Philadelphia, involves injecting mitochondria taken from cumulus cells, which surround developing eggs in the ovary, and injecting them into the woman's eggs in the laboratory. Of 71 IVF treatment attempts using the technique, 35 per cent resulted in a pregnancy and 20 babies have been born, reported team leader Chii-Ruey Tzeng, of Taipei Medical University. 'I think it can rescue a lot of patients', he said, although other fertility experts say more research is needed into the safety and effectiveness of the method.

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6 June 2011 - by Dr Marianne Kennedy 
Women at risk of passing on mitochondrial disease to their children could use PGD to give birth to an unaffected child. The scientists at Maastricht University Medical Centre in the Netherlands claim their work has the potential to prevent the transmission of mitochondrial diseases...
11 February 2008 - by Dr Rebecca Robey 
Scientists at the University of Newcastle are developing a technique that they hope will enable women with a group of devastating hereditary illnesses - known as mitochondrial diseases - to have children without passing on their genetic disorders. Because the method involves sperm from one man and two eggs...
12 September 2005 - by Dr Virginia Bolton 
This week saw another very positive illustration of the rigour and effectiveness of the regulatory system that exists in the UK to licence research using human embryos. However, it also highlighted ambiguities in the wording of the 1990 Human Fertilisation and Embryology Act, which is currently the focus of a...
9 September 2005 - by BioNews 
The UK's Human Fertilisation and Embryology Authority (HFEA) has issued a licence to a team of scientists who want to carry out research on human embryos aimed at preventing genetic conditions caused by faults in the 'powerhouses' of the cell. Researchers at the University of Newcastle, funded by the Muscular...
16 October 2003 - by BioNews 
Researchers from Sun Yat-Sen University in Guangzhou, China have succeeded in creating a pregnancy using an embryo containing the genetic material of three different people. An egg cell taken from one woman was fertilised by in vitro fertilisation (IVF), creating a one-cell embryo, or zygote. The nucleus of the zygote...
8 May 2001 - by BioNews 
Scientists in the US have announced that babies have been born carrying the DNA of three parents: two women and a man. The babies were the result of a controversial program using ooplasmic transplantation - effectively adding cytoplasm from a donor woman's egg to that surrounding the nucleus of an infertile...
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