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A gene for cleft palate discovered

17 September 2001
By BioNews
Appeared in BioNews 125
Scientists from Imperial College in London have identified a gene that causes children to be born with cleft palates. The scientists discovered that mutations in the T-box 22 gene cause the sex-linked form of the condition, known as CPX, and also another condition known as 'tongue-tie'.

The leader of the researchers, Dr Philip Stanier, hopes that the discovery will lead to better diagnosis and treatment of the condition. He said 'by identifying the gene that causes X-linked cleft palate we now understand much more about the cause of the condition. In the long term it will also shed more light on other forms of the condition and lead to effective treatments other than corrective surgery.'
Cleft palate gene found
BBC News Online |  16 September 2001
25 September 2006 - by Laura Goodall 
A developmental gene has been found to provide a connection between several genes involved in the formation of a cleft lip and palate. Researchers at Brigham and Women's Hospital and Harvard Medical School in Massachusetts, US found that when the gene SUMO1 is under-expressed and does not...
20 August 2004 - by BioNews 
A new genetic test could allow doctors to identify people at risk of having a second child with a cleft lip or palate. Researchers at the University of Iowa in the US found that variations in a particular gene are linked to a three-fold increased risk of the condition recurring...
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