Page URL:

Men over 50 less likely to have successful fertility treatment

23 August 2021
Appeared in BioNews 1109

The chance of live birth following assisted reproduction is significantly reduced when the prospective father is over the age of 50, a recent study has revealed. 

Despite the belief that male fertility is not subject to a biological clock, a group of researchers at the Centre for Reproductive and Genetic Health in London found that when the father is over the age of 50 the likelihood of a live birth following IVF or ICSI is 33 percent lower than for men under the age of 50. The rates of miscarriage remain unchanged, a finding which is echoed among other similar studies.  

'Paternal age over 50 significantly affects the chance of achieving a live birth following assisted reproductive technology. There should be a public health message for men to not delay fatherhood', the authors wrote.

The findings were originally revealed at the European Society of Human Reproduction and Embryology in 2019 (see BioNews 1004), and were published in the journal Acta Obstericia et Gyneologica Scandinavica this month. Data was taken retrospectively from nearly 4300 adults who had undergone IVF or ICSI using fresh sperm and embryo transfer at a single London fertility clinic. This report comes amid a growing trend of men fathering children much later in life. Dr Guy Morris, lead author of the study, said in the Daily Mail that publicised stories of male celebrities over 60 still having children has helped to fuel the incorrect belief that 'male fertility lasts forever'. 

The age-related decline in fertility amongst women is well-documented. Interestingly, the analysis of this data showed that the decline in live births occurred irrespective of female age. This is a particularly important finding as it underlines the previously unknown significance of male age when fathering children. 

This study included males affected by all forms of infertility, thereby improving the validity of these findings, and making them applicable to all couples. Furthermore, the researchers considered additional variables such as semen quality and the method of fertilisation, yet still found that male age negatively impacted fertility independent of the variation in these factors.  

However, several lifestyle factors, including smoking, body mass index and alcohol consumption, could not be controlled. It is plausible that these factors may also negatively influence fertility amongst males. The study did go on to report a lower level of sperm quality amongst males over 50 when compared to those of a younger age. This may begin to explain the decline in fertility, however the mechanisms through which this could occur are yet to be characterised. 

4 April 2022 - by David Cansfield 
Testicular tubules have been created using a 3D printing technique for the first time ever, which may provide hope for men with infertility...
26 June 2019 - by Shaoni Bhattacharya 
The chance of success with fertility treatment using IVF or ICSI decreases if a man is over 51, according to a new study...
20 May 2019 - by Sarah Gregory 
New research has shown that men who start a family later in life are more likely to experience fertility problems and can increase the risk of health issues in their children...
5 November 2018 - by Eleanor Mackle 
Older men are more likely to have children born prematurely, a study in the USA has found, while their partners are at higher risk of developing gestational diabetes...
21 May 2018 - by Annabel Slater 
It's a first for the Progress Educational Trust - an event dedicated solely to male fertility: Time Waits for No Man...
3 July 2017 - by Shaoni Bhattacharya 
The success of IVF in women under the age of 40 may be affected by the age of their male partners, suggests a US study...
to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions

Syndicate this story - click here to enquire about using this story.