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First US baby born after uterus transplant

11 December 2017
Appeared in BioNews 930

A woman in Texas has become the first person in the USA to give birth after receiving a uterus transplant.

The anonymous patient has a genetic condition called Mayer-Rokitansky-Küster-Hauser syndrome. Born without a uterus, she was unable to carry a child without medical intervention. Doctors at Baylor University Medical Centre in Dallas managed to successfully transplant a donor uterus into her body to allow her to conceive through IVF.

'It doesn't really matter how many babies you've delivered, this was a very special moment,' said Dr Giuliano Testa, head of the study, speaking to NPR.

Originally pioneered in Sweden several years ago, the transplant procedure involves removing a healthy uterus from a living volunteer or recently deceased donor. The donated tissue is then used to replace the absent uterus. 

Doctors at Baylor have been running a study attempting to replicate the procedure in US patients. So far four women have received transplants at Baylor (see BioNews 872), but this is the first to successfully result in pregnancy. The other three transplanted uteruses had to be removed due to insufficient blood flow.

One of the Swedish doctors involved in the study, Dr Liza Johannesson, told NPR: 'For the recipient, the transplant itself takes about five hours... Then after you have the transplant, you don't have an immediate success. First you have to know the uterus is staying with the recipient.'

The transplants themselves are meant to be temporary, as they require the patient to take powerful immunosuppressant drugs to prevent rejection. Once doctors are certain the transplant will not be rejected, the women are impregnated through IVF. After a woman successfully carries a child to term, the transplanted tissue can be removed.

The American Society for Reproductive Medicine also issued a statement calling the birth in Texas 'another important milestone in the history of reproductive medicine'. So far only around 16 uterus transplants have been performed worldwide, including some that failed to produce successful pregnancies. However, last month Penn Medicine in Philadelphia, Pennsylvania, announced a clinical trial offering uterus transplants. 

It’s hoped that one day the procedure may also be able to help women with uteruses damaged by cancer, infectious diseases or previous childbirths.

ASRM Responds to News of Birth Following Successful Uterus Transplant
ASRM |  4 December 2017
First baby born to US uterus transplant patient raises ethics questions
npr |  5 December 2017
First baby from a uterus transplant in the US born in Dallas
The Telegraph |  2 December 2017
First US baby born after a uterus transplant
Time |  1 December 2017
Woman with transplanted uterus gives birth, the first in the US
New York Times |  2 December 2017
12 April 2021 - by Eleanor Mackle 
A human uterus transplant is estimated to have a total cost of €74,564 on average, according to a new study from Sweden...
15 April 2019 - by Martha Henriques 
The first baby to be born after their mother received a robot-operated womb transfer has been delivered in Sweden...
25 March 2019 - by Ana Hallgarten 
The Progress Educational Trust (PET) symposium event 'Revolutionising Reproduction: The Future of Fertility Treatment' took place at the Royal College of Physicians of Edinburgh on the 19th March 2019...
17 December 2018 - by Dr Natasha Hammond-Browning 
The news broke on the 4 December 2018 that clinicians had achieved a successful pregnancy and live birth following a uterus transplant from a deceased donor...
10 December 2018 - by Shaoni Bhattacharya 
The world's first baby has been born from a uterus transplanted into a woman from a dead donor...
21 November 2016 - by Dr Natasha Hammond-Browning 
Sixteen uterus donations have occurred worldwide, and so far only a research team in Sweden has carried out transplants that successfully produced live births. The Swedish trial involved donations from living persons...
17 October 2016 - by Dr Nicola Williams 
This symposium was organised to facilitate in-depth discussion as well as international and interdisciplinary collaboration between academics and clinicians with an interest in uterus transplantation (UTx), which would allow women who lack a functioning uterus to become pregnant and give birth to their own babies...
10 October 2016 - by Sarah Pritchard 
Four women in the USA have become the first in the country to receive uteruses transplanted from living donors...
12 October 2015 - by Nina Chohan 
Ethical approval has been given for clinical trials involving ten womb transplants in the UK to go ahead....
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