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Study suggests freezing ovarian tissue instead of eggs

17 July 2017
Appeared in BioNews 909

Freezing ovarian tissue may provide a viable option for women who want to preserve their fertility, according to a recent study.

For many women, for example those undergoing cancer treatment, freezing their eggs provides them with a possibility of getting pregnant later in life. However, collecting eggs for freezing can take time and is not always an option for women who need to undergo urgent treatment.

In a recent study, published in Reproductive Sciences, doctors from New York Medical College suggest that freezing ovarian tissue could offer an alternative for such women.

'The procedure is superior to egg freezing as it can also reverse menopause and restore natural fertility' said senior study author Dr Kutluk Oktay, one of the pioneers of the technique.

The researchers carried out a meta-analysis of existing reports on the procedure that have been published between 1999 and 2016. They identified a total of 19 studies and analysed data from these on a total of 309 women who had undergone ovarian tissue transplantation.

Based on these studies, the scientists found that the treatment was successful at restoring reproductive functions or reversing the menopause in two thirds of the women. In total, 84 babies had been born following ovarian tissue transplant, as well as eight ongoing pregnancies.

'Despite the clinical progress within the past two decades, the procedure still remains in the experimental realm,' said co-author Dr Fernanda Pacheco. 'Now, women considering this procedure to preserve fertility and postpone childbearing have more information at their disposal. Given these recent data, ovarian tissue cryopreservation should be considered as a viable option for fertility preservation.'

However, more research is still needed: 'the data we have on fertility preservation is pretty poor,' Jake Anderson, cofounder of FertilityIQ, told TIME. 'There are lots of small, single-centre studies which lack the rigour and generalizability of a multi-centre, prospective trial. It's still unclear how many women will actually come back and use what they've preserved.'

Dr Kutluk wants to find out if the technique can help other women prolong fertility:  'The next frontier is to explore the procedure's potential in delaying childbearing among healthy women, not just cancer patients.'

Current Success and Efficiency of Autologous Ovarian Transplantation: A Meta-Analysis
Fertility and Sterility |  18 October 2016
Freezing Ovarian Tissue May Be a Promising Fertility Treatment
Time |  13 July 2017
Is 'ovarian tissue freezing' superior to egg freezing?
Science Daily |  13 July 2017
'Ovarian tissue freezing' may provide hope for fertility treatment
Zee News |  14 July 2017
19 August 2019 - by Melanie Davies 
Ovarian tissue freezing is offered to some young cancer patients to preserve their fertility before chemotherapy or radiotherapy...
12 August 2019 - by Dr Rosie Morley 
Women could delay the menopause for up to 20 years according to a UK clinic offering the procedure commercially...
6 November 2017 - by Eleanor Taylor 
As a 33-year-old single woman, who also happens to work in a fertility clinic, babies are unsurprisingly never far from my mind. I spend a lot of time wondering whether I should freeze my eggs. A lot...
10 July 2017 - by Mikey Lebrett 
Female cancer survivors are 38 per cent less likely to become pregnant compared with women in the general population, according to a study presented at the annual European Society of Human Reproduction and Embryology conference in Geneva...
19 December 2016 - by Dr Rosie Morley 
A 24-year old has become the first woman to give birth after a transplant of ovarian tissue that was taken before puberty...
12 September 2016 - by Sophie Perry 
A study of women opting to freeze their eggs for non-medical reasons has revealed that the most common motivation given was not yet finding the right partner...
18 July 2016 - by Rebecca Carr 
A cancer patient in Edinburgh has become the first woman in the UK to have a child following a transplant of her frozen ovarian tissue...
21 March 2016 - by Antony Starza-Allen 
A 23-year-old woman may soon become become pregnant after receiving an implant of an ovary that had been frozen since she was eight years old...
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