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Over 600,000 at risk of sudden death from faulty heart gene

6 February 2017
Appeared in BioNews 887

About 620,000 people in the UK carry a faulty heart gene that puts them at high risk of sudden death or developing coronary heart disease, the British Heart Foundation (BHF) has warned.

The figure is 100,000 times more than previous estimates and could be even higher due to under-diagnosis and as yet undiscovered faulty genes.

'The reality is that there are hundreds of thousands of people across the UK who are unaware that they could be at risk of sudden death,' said Professor Sir Nilesh Samani, BHF's medical director.

He added: 'If undetected and untreated, inherited heart conditions can be deadly, and they continue to devastate families, often by taking away loved ones without warning.'

A child of someone with certain genetic heart conditions has a 50 percent chance of inheriting it themselves. In the UK, around 12 people aged 35 or under die each week from sudden cardiac arrest with no explanation.

Last April, former England and Nottinghamshire cricketer James Taylor was forced to retire at the age of 26, because of a rare but serious genetic heart condition – arrhythmogenic right ventricular cardiomyopathy (ARVC), which is caused by a mutation in one or more genes.

'It is safe to say that being diagnosed with ARVC was the toughest and scariest week of my life,' Taylor told The Guardian. 'I never would have thought it would happen to me. I was 26 years old and playing cricket for England but my condition meant that I was at risk of sudden death from a cardiac arrest.'

'I was lucky as my condition was detected early and despite having to give up my career, with medication I can lead a relatively normal life,' he added.

Research has helped to discover many faulty genes that cause inherited heart conditions. 'Thanks to the public's kind support, our researchers have discovered some of the genes responsible for these frightening conditions but there is still much to do,' said Professor Samani.

SOURCES & REFERENCES
600,000 Britons could die at any moment from faulty gene, experts warn
The Independent |  1 February 2017
620,000 people in UK 'at risk of sudden death from faulty heart gene'
The Guardian |  1 February 2017
Hundreds of thousands at risk of sudden death from silent heart conditions
British Heart Foundation (press release) |  1 February 2017
Sudden death warning over faulty heart gene
BBC News |  1 February 2017
The sudden death gene: Calls to screen for silent killer as 620,000 face increased heart risk
Mail Online |  1 February 2017
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