Page URL:

Stem cell test could improve leukaemia treatment

7 December 2016
Appeared in BioNews 881

Researchers have developed a stem cell test that could rapidly predict how patients with acute myeloid leukaemia (AML) will respond to treatment.

The test is based on 17 genes that are highly expressed in leukaemia stem cellS (LSCs). Patients showing strong activation in these genes (a high LSC17 biomarker score) are less likely to respond well to standard chemotherapy treatment. The new test could help doctors to direct such patients to alternative treatments.

'The LSC17 score is the most powerful predictive and prognostic biomarker currently available for AML, and is the first stem cell-based biomarker developed in this way for any human cancer,' said Dr Jean Wang, an affiliate scientist at the Princess Margaret Cancer Centre, Toronto, and co-lead of the study. 'Clinicians will now have a tool that they can use upfront to tailor treatment to risk in AML.'

LSCs are considered the primary reason for the high rate of relapse and treatment failure in AML. As stem cells have the ability to exist in a dormant state, this makes them resistant to therapy.

In the study, published in Nature, researchers analysed LSCs from blood or bone-marrow samples from 78 AML patients and identified 17 strongly activated genes. The scores were linked to patient outcomes for 908 patients in Canada and Europe.

Genetic tests for AML are routinely performed to assess patient risk level, but results generally take weeks to arrive. By contrast, the 17-gene test score can provide similar clinical information in less than two days.

'AML is an acute condition, and every day counts,' observed Stanley Ng, a senior PhD candidate at the University of Toronto, and co-lead of the study. 'For this reason, clinicians usually start treatment right away, without waiting for the test results.'

Dr Gerrit Jan Schuurhuis of the VU University Medical Centre, Amsterdam, who was not involved in the study, pointed out that the clinical benefits of the LSC17 score remain to be assessed because 'prognostic value does not always lead to a meaningful clinical advantage'.

Nevertheless, he said the study paved the way for a more refined understanding of LSC properties at diagnosis, which could enable clinicians to design personalised and more effective therapies.

A clinical trial of the LSC17 test is planned for next year.

A 17-gene stemness score for rapid determination of risk in acute leukaemia
Nature |  7 December 2016
Cancer: A gene-expression profile for leukaemia
Nature |  7 December 2016
New stem cell-based gene test predicts patient risk in acute myeloid leukemia
University of Toronto Engineering News |  7 December 2016
Stem cell-based test predicts leukemia patients' response to therapy to tailor treatment
Eurekalert (press release) |  7 December 2016
Stem cell biomarker predicts leukemia patients' response to chemo
Fierce Biotech |  7 December 2016
4 September 2017 - by Meetal Solanki 
The world's first cancer treatment which uses a patient's own genetically modified immune cells has been approved...
13 February 2017 - by Emma Laycock 
A new blood test can predict how well patients with myelodysplastic syndrome will respond to bone-marrow transplants...
13 June 2016 - by Amina Yonis 
A study on the blood cancer acute myeloid leukaemia has shown which combinations of mutations lead to the most aggressive forms of the disease and revealed a complicated picture at the genetic level...
22 February 2016 - by Julianna Photopoulos 
Trials using genetically engineered immune cells have shown 'extraordinary results' in treating blood cancers in terminally ill patients, say researchers...
13 October 2014 - by Dr James Heather 
Gene therapy to treat children with 'bubble boy syndrome' seems to be both safe and effective, a study published in the New England Journal of Medicine has found...
17 February 2014 - by Dr Barbara Kramarz 
A leukaemia patient in the UK, previously given up to 18 months to live, is now in remission after transplant of stem cells from two babies' umbilical cords.
16 December 2013 - by Dr Rachel Montgomery 
Gene therapy trials using engineered immune cells have shown considerable progress in treating blood disorders, according to findings presented at the American Society of Hematology's annual meeting...
to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions

Syndicate this story - click here to enquire about using this story.