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Womb transplant mother pregnant again

27 June 2016
Appeared in BioNews 857

A Swedish woman who gave birth in 2014 following a womb transplant is pregnant with a second child.

The woman is one of nine patients without a functioning uterus who received a womb transplant as part of a clinical trial led by Professor Mats Brännström of the University of Gothenburg, Sweden. The wombs were donated by living donors, in most cases from the recipients' own mothers but also from friends and other relatives.

The trial has so far resulted in five births using embryos created by IVF. The participants are to be offered a chance of a second pregnancy six months after the first, but after that the uterus would then be removed (see BioNews 775).

The transplantation procedure isn't without risk, however. The procedure requires the recipient to take strong immunosuppressive drugs to stop the body's immune system from rejecting the donated womb, and two women had their transplanted wombs removed after complications involving an infection and thrombosis. In this case the donor, who was the woman's grandmother, the mother and first child are all healthy three years after transplantation procedure.

Announcing the news of the pregnancy at the annual meeting of the Royal College of Obstetricians and Gynaecologists (RCOG) in Birmingham, Professor Brännström said the future lies in attempting to grow a womb from a woman's own stem cells.

'The concept is: you create from stem cells of the recipient and transplant that into the recipient,' Professor Brännström said. 'You have a substitute for a damaged organ and keep it without immunosuppression.'

He added: 'We have started in a rat, and we have now published a paper where we have not been able to create a whole uterus but uterus-patches, bio-engineered. These may be the future, but we'll of course need a lot of research.'

Womb transplants offer an alternative to surrogacy or adoption for women affected by absolute uterine-factor infertility, or who have had to remove their womb due to disease such as cancer. Transplants are currently being planned in the UK using deceased donors, after Imperial College London received ethical approval last year to start a clinical trial involving ten patients (see BioNews 823).

Commenting on the news, Professor Richard Smith who is leading the UK's efforts to perform womb transplants, said: 'Absolute uterine infertility is a huge and growing problem affecting tens of thousands of women in this country – and the success of the Swedish team shows that at least some of these women will be able to bear their own child where before there was no hope.'

Professor Alan Cameron, RCOG's vice president of clinical quality, said: 'The RCOG congratulates the scientific advances made by Professor Mats Brannstrom and his team.'

He added: 'Uterine transplantation is still a very new and experimental procedure, which is currently only conducted through clinical trials.'

Infertile women could get new wombs grown from stem cells within 10 years, says transplant pioneer
Daily Telegraph |  20 June 2016
Second baby for womb transplant mum
BBC News |  20 June 2016
25 March 2019 - by Ana Hallgarten 
The Progress Educational Trust (PET) symposium event 'Revolutionising Reproduction: The Future of Fertility Treatment' took place at the Royal College of Physicians of Edinburgh on the 19th March 2019...
11 June 2018 - by Sarah Pritchard 
The charity Womb Transplant UK has announced its intention to carry out the first womb transplant in the UK by the end of 2018, with living as well as deceased donors...
15 May 2017 - by Georgia Everett 
A hospital in India is preparing this week to conduct the country’s first ever womb transplant...
21 November 2016 - by Dr Natasha Hammond-Browning 
Sixteen uterus donations have occurred worldwide, and so far only a research team in Sweden has carried out transplants that successfully produced live births. The Swedish trial involved donations from living persons...
17 October 2016 - by Dr Nicola Williams 
This symposium was organised to facilitate in-depth discussion as well as international and interdisciplinary collaboration between academics and clinicians with an interest in uterus transplantation (UTx), which would allow women who lack a functioning uterus to become pregnant and give birth to their own babies...
18 April 2016 - by Dr Natasha Hammond-Browning 
The first US uterus transplant was carried out in February, but before we continue down this route we need to ask whether the risks outweigh the benefits of these procedures...
12 October 2015 - by Nina Chohan 
Ethical approval has been given for clinical trials involving ten womb transplants in the UK to go ahead....
13 October 2014 - by Dr Amel Alghrani 
Following the first baby born after a womb transplant, the time has come to debate uterus transplantation. How will it be regulated in the UK and what social, legal and ethical issues does it raise?
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