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Artificial sperm 'grown in lab' for first time

18 May 2015
Appeared in BioNews 802

A French company claims to have grown human sperm cells in a laboratory for the first time.

The Kallistem Laboratory, in Lyon, said it had produced sperm cells using patient testicular biopsies that contained immature germ cells, but the research is yet to be published in a peer reviewed journal.

The researchers claim that their work will enable them to extract reproductive cells from a male patient and store them until he decides to have a child. So far this process has proved effective in mice (reported in BioNews 761) but still needs to be tested in humans.

The company said it will be holding pre-clinical trials in 2016 and, if they're successful, clinical trials may go ahead in 2017.

Isabelle Cuoc, Kallistem's CEO, said: 'Our team is the first in the world to have developed the technology required to obtain fully formed spermatozoa in vitro with sufficient yield for IVF. This is a major scientific outcome that enhances both our credibility and our development potential.

'We are targeting a global market worth several billion euros in which there are currently no players.'

Nonetheless, some scientists are treating this research with caution until it is proven. Allan Pacey, professor of andrology at the University of Sheffield, told the Daily Mail: 'This is a bold claim to make and we have had our fingers burnt before. Until I see a peer-reviewed scientific publication showing unequivocally that this has been done, I have to remain sceptical.'

He added: 'Claims like this can often cause heartache for infertile couples who see them as hope, only to have their hopes dashed later when it doesn't translate into an available procedure.'

Nathalie Rives, manager of the CHU fertility clinic in Rouen, France, told Le Figaro: 'If it works, this procedure opens great prospects.' Though, she added that some men might have 'genetic anomalies' which could exclude them from the process.

French lab claims breakthrough with first in vitro spermatozoa
Yahoo News (AFP) |  8 May 2015
Kallistem achieves complete human spermatogenesis in vitro for treatment of male infertility
News-Medical (press release) |  5 May 2015
Scientists grow sperm in laboratory for first time
The Telegraph |  9 May 2015
Sperm created in lab in world first, French company claims
The Independent |  9 May 2015
World first as SPERM is grown in a lab for the first time
Mail Online |  9 May 2015
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21 March 2016 - by Dr Kimberley Bryon-Dodd 
Researchers have discovered a receptor on the cell membrane of sperm that is vital for their activation...
7 March 2016 - by Dr Dusko Ilic 
A recent announcement that scientists had created functioning spermatozoids from mouse embryonic stem cells in the lab made quite a splash in the media. However, one key point seemed to be overlooked...
26 January 2015 - by Dr Kimberley Bryon-Dodd 
A US study has found that despite increased use of ICSI over recent years, the technique is not associated with any improved reproductive outcomes over conventional IVF...
12 January 2015 - by Dr Linda Wijlaars 
For the first time, researchers have succeeded in creating human sperm and egg precursor cells from stem cells...
7 July 2014 - by Siobhan Chan 
Healthy mice have been born using sperm grown in the lab from a sample of cryopreserved testicular tissue...
6 May 2014 - by Siobhan Chan 
Skin tissue from infertile men has been converted into sperm cell precursors after their stem cells were transplanted into mice...
Brilliant read! ( - 23/05/2015)
It's crazy to see how times have changed... arteficial sperm? if they can so something as unethical as that, I would love to know what scientist 'cant' arteficially produce!
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