'Preimplantation Genetic Diagnosis 2018: Current Practice and Beyond', 9-10 November 2018
Page URL: https://www.bionews.org.uk/page_94406

Gout mostly genetic, study suggests

16 December 2013
Appeared in BioNews 735

Alcohol and a diet rich in animal protein may not be solely responsible for gout, as the inflammatory disease could be genetically related, according to a nationwide population study in Taiwan.

Researchers at the University of Nottingham studied the entire population of Taiwan, where gout is most prevalent in the world. From the four million people whose families they could identify, there were one million individuals with physician-diagnosed gout. The team found that the risk for gout was higher in people with a family history of the disease.

Dr Chang-Fu Kuo, principal investigator of the project, said: 'Our results confirm the clinical belief that gout strongly clusters within families'.

'In Taiwan the risk of an individual with any first-degree relative suffering from gout is approximately twice that of the normal population'.

'The risk increases with the number of the first-degree relatives affected. Having a twin brother with gout carries an eight-fold risk, whereas having a parent or offspring with gout has a two-fold risk', Dr Chang added.

Gout is a painful inflammatory disease, mainly associated with the accumulation and deposition of uric acid or monosodium urate crystals in joints. Scientists have long known that alcohol hinders excretion of uric acid into urine, and that certain diets contribute to the severity of its formation.

Dr Michael Doherty, head of the Arthritis Research UK Pain Centre at the University of Nottingham and co-author of the study, said: 'We found evidence for both shared environmental factors and genetic factors in predisposing to gout within families, with environmental factors contributing a higher proportional risk'.

'Both genetic and environmental factors play a role in gout pathogenesis. Having an affected family member increases the risk but part of the risk comes from modifiable shared environmental factors such as diet and lifestyle'.

The study was published in the journal Annals of the Rheumatic Diseases.

SOURCES & REFERENCES
Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan
Annals of the Rheumatic Diseases |  21 November 2013
Gout may be genetic, scientists find
The Telegraph |  3 December 2013
Gout Risk Linked With Family History
Huffington Post |  2 December 2013
New evidence that 'gout' strongly runs in the family
EurekAlert! (press release) |  2 December 2013
RELATED ARTICLES FROM THE BIONEWS ARCHIVE
28 May 2013 - by Dr James Heather 
Uncomfortable shoes might not be only to blame for bunions, as the foot condition could have a genetic link, according to a study...
9 July 2012 - by Helen Brooks 
Scientists have identified eight regions of the genetic code associated with an increased risk of developing osteoarthritis...
18 July 2011 - by Sarah Pritchard 
A team of international researchers have identified several new genetic variants that are involved in a type of incurable spine arthritis – ankylosing spondylitis (AS) – offering hope for novel treatments for those with the condition...
6 June 2011 - by Dr Kimberley Bryon-Dodd 
Three genetic regions have been linked for the first time to a bone disease called Paget's disease by an international research team. Genes in these regions and four others identified in a previous study explain about 13 percent of the risk of developing the disease....
HAVE YOUR SAY
Log in to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions


Syndicate this story - click here to enquire about using this story.