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Scientists unpick actions of faulty gene behind red meat bowel cancer risk

13 August 2012
Appeared in BioNews 668

A faulty gene linked to bowel cancer interacts with dietary iron to significantly increase the risk of developing the disease, research on mice suggests.

Professor Owen Sansom, deputy director of the Cancer Research UK Institute for Cancer Research in Glasgow, who led the study, said that the gene in question, called APC, 'is faulty in around eight out of ten bowel cancers but until now we haven't known how this causes the disease'.

Bowel cancer is the third most common cancer in the UK, with 41,000 cases diagnosed each year. Around 16,000 of people die from the disease annually.

The scientists tested mice with and without the faulty gene and fed one group a diet high in iron and another no iron. They found that the iron reacted with the non-working gene to drastically increase the likelihood of developing bowel cancer. The risk was two to three times higher than those mice that had a working APC gene.

Writing in the journal Cell Reports, the researchers say that the faulty APC gene allows iron to build up in the cells lining the gut. This activates a key cancer signalling pathway called wnt, causing cells to grow out of control.

The study may explain why diets high in red meat, which contains a lot of iron, are associated with bowel cancer. But Professor Sansom commented that the study 'shows that even very high levels of iron in the diet don't cause cancer by itself, but rely on the APC gene'. The mice with the faulty APC gene that were fed with a low iron diet did not develop the disease as the faulty cells were killed.

Co-author Dr Chris Tselepis, a Cancer Research UK scientist at the University of Birmingham, said: 'Our results also suggest that iron could be raising the risk of bowel cancer by increasing the number of cells in the bowel with APC faults. The more of these cells in the bowel, the greater the chance that one of these will become a starting point for cancer'.

He added that the team was 'planning to develop treatments that reduce the amount of iron in the bowel and so could lower the risk of developing bowel cancer'.
Iron 'may raise bowel cancer risk'
Press Association |  9 August 2012
Luminal Iron Levels Govern Intestinal Tumorigenesis after Apc Loss In Vivo
Cell Reports |  9 August 2012
Red meat could raise risk of cancer 'due to high levels of iron'
Mail Online |  9 August 2012
Scientists discover how iron levels and a faulty gene cause bowel cancer
Cancer Research UK (press release) |  9 August 2012
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