The Fertility Show, Manchester Central, 24-25 March 2018
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UK surgeons launch womb transplant charity

16 July 2012
Appeared in BioNews 665

A charity has been launched to raise money for research that could allow the first womb transplants in the UK.

Uterine Transplantation UK was set up by a team of British surgeons who say they need £500,000 to finish testing the procedure. Only after tests in animals have been completed will they be able to apply for ethics permission to perform the surgery in patients.

Womb transplantation offers an alternative to surrogacy or adoption for thousands of women who are either born without a womb or have theirs removed due to birthing complications, cancer or other diseases.

A previous attempt at this surgery in 2000 failed because of a problem in the blood supply to the transplanted uterus. However, several improvements to the technique have been made and last August a 21-year old woman in Turkey became the first successful recipient of a womb transplant.

'We are confident, especially with a transplant abroad being carried out with the same methodology that we have recommended that within two years or so, given enough funding, we can begin helping women in the UK', said Mr Richard Smith, a consultant gynaecologist from Imperial College Healthcare NHS Trust and the Lister Hospital.

Mr Smith says he has been approached by 50 women who have or could have frozen embryos from IVF and who would like a womb transplant.

However, the surgery would not be without risk. The woman may be at increased risk of complications in pregnancy, including miscarriage, and it is not yet clear whether there could be adverse effects on the development of the implanted embryo. Like any transplant, the recipient will also need to remain on immunosuppressant medication to prevent rejection. To avoid long-term effects, the womb would need to be removed after one or two pregnancies.

Womb transplantation is not a life-saving operation, so some question whether such risks are justified. Professor Lord Robert Winston has said previously that the risks are not worth taking and some women may have to accept that, unless they adopt, they will never become mothers. 'There are some people who are not going to have a child and sad though that is, that has to be seen', he said.

Professor Charles Kingsland, spokesman for the Royal College of Obstetricians and Gynaecologists, said: 'Significant concerns need to be addressed to everybody's satisfaction before we go ahead and offer this as a viable option'.

20 January 2014 - by Dr Rosie Gilchrist 
Nine women have received transplants of uteruses donated by their mothers or other living relatives in an ongoing trial of an experimental procedure at the University of Gothenburg in Sweden...
20 May 2013 - by Dr Anna Cauldwell 
Doctors have terminated the pregnancy of 22-year-old Derya Sert, the first woman to receive a womb transplant from a deceased donor....
15 April 2013 - by Antony Blackburn-Starza 
One of the first women to receive a womb transplant is pregnant, the treating hospital has disclosed. A spokesperson said that early test results were 'consistent' with signs of pregnancy....
24 September 2012 - by Ruth Retassie 
Two women in Sweden received uterus transplants from their mothers, with hopes it will allow them to conceive children of their own...
1 August 2011 - by Dr Morven Shearer 
Last month news broke of an experimental womb transplantation surgery planned for early next year. With it came the possibility of women with an absent or non-functioning uterus carrying a child to term (see Roberts, 2011)....
20 June 2011 - by MacKenna Roberts 
A British woman has agreed to donate her womb to her daughter if selected for an experimental womb transplant surgery to be performed by doctors at the University of Gothenburg in Sweden....
10 April 2007 - by Heidi Nicholl 
A Swedish team has successfully carried out womb transplants in sheep, leading to pregnancy. So far the researchers have worked on perfecting the technique of reconnecting the blood vessels and have removed and replaced the uterus in individual animals - known as autologous transplantation. The team removed and...
22 January 2007 - by Antony Blackburn-Starza 
Doctors based at the New York Downtown Hospital, have been given the go-ahead to begin screening women to undergo the first womb transplant in the US. The procedure will involve the removal and transferral of a uterus from a dead donor to a female recipient. After waiting...
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