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Gene variants linked to childhood obesity discovered

16 April 2012
Appeared in BioNews 652

Two new genetic variants that could increase the risk of childhood obesity have been identified in the largest ever genome-wide study of the disease.

In contrast to previous studies looking at extreme forms of obesity, this research focused on common childhood obesity, said Dr Struan Grant, study author and Associate Director at the Center for Applied Genomics at The Children's Hospital of Philadelphia.

Obesity is unlikely to be caused purely by genetics, but the presence of these two gene variants, which Dr Grant says are 'very common in the population', may increase the likelihood of becoming obese in the early years of life. He suggests the alterations may function in the intestinal tract and influencing the activity of natural bacteria.

The study, published in Nature Genetics, combined data from 14 studies conducted in the USA, Canada, Australia and Europe. In total, the genomes of 5,530 obese children and 8,318 non-obese controls were analysed.

They identified two variants - one near a gene on chromosome 13, and one near a gene on chromosome 17.

'Certain kids, even in the best environments, are prone to be obese because of genetics. Actually identifying the genes really helps', said Karen Winer, of the Eunice Kennedy Shriver National Institute of Child Health and Human Development in an interview with Time Healthland.

However, the gene variants are not guaranteed to make a child obese; while they may increase the risk, weight gain is still thought to be largely due to environmental factors. As such, researchers advise that a healthy lifestyle, exercising and eating the right foods is still the best way to avoid obesity.

A genome-wide association meta-analysis identifies new childhood obesity loci
Nature Genetics |  8 April 2012
Childhood obesity genes identified, scientists say
CBS News |  8 April 2012
Childhood Obesity: Scientists Find Two Gene Variants that Predispose Kids to Weight Gain Read
Time |  9 April 2012
Genes identified for common childhood obesity
Eurekalert |  8 April 2012
Obese Kids: Genes and Junk Food Share Blame
ABC MedPage Today |  9 April 2012
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