Page URL: https://www.bionews.org.uk/page_92508

Scientists create regenerative cells from mouse cells

9 August 2010
Appeared in BioNews 570
Regrowing human tissue is one step closer after scientists found manipulating two key proteins in mouse muscle cells enabled them to continue multiplying. Blocking two proteins - ARF, responsible for restricting cell growth, and RB1, which suppresses cancer - caused the muscle cells to start dividing. Normally, mammal muscle cells don't divide.

But the scientists warned more research was needed before the technique could be used to regenerate tissue to treat conditions like heart damage and muscle-wasting diseases. The proteins could only be deactivated temporarily because otherwise they over-proliferated. RB1 helps stop cancerous tumours developing.

'Newts regenerate tissues very effectively', said Professor Helen Blau from Stanford University, California, who led the research. Scientists have long been interested in how newts and salamanders regrow their body parts. 'In contrast, mammals are pathetic. We can regenerate our livers, and that's about it. Until now it's been a mystery as to how they do it', she said.

SOURCES & REFERENCES
Cell success on mice holds out hope for regenerative medicine
The Times |  5 August 2010
Transient Inactivation of Rb and ARF Yields Regenerative Cells from Postmitotic Mammalian Muscle
Cell Stem Cell |  6 August 2010
RELATED ARTICLES FROM THE BIONEWS ARCHIVE
5 December 2011 - by Rose Palmer 
Breakthroughs in biology that 'will transform the resilience and strength of the human body' are the subject of the last episode of Stephen Hawking's brilliant series 'Brave New World'. In just under an hour 'Biology' takes the viewer on a whirlwind tour of some of the newest and most awe-inspiring technologies. We're talking cures for cancer, organ regeneration and experiments in longevity and heritability...
18 June 2010 - by Rosemary Paxman 
Functional lab-grown livers could become a reality within 5-10 years, suggests a new study published by Nature Medicine, offering hope to liver transplant patients....
22 March 2010 - by Dr Marianne Kennedy 
The ability for mammals to regenerate damaged tissue without scarring has been demonstrated for the first time by a research team based at the Wistar Insitute, Philadelphia...
HAVE YOUR SAY
Log in to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions


Syndicate this story - click here to enquire about using this story.