Page URL:

New York surgeons announce plans for womb transplant

22 January 2007
Appeared in BioNews 392

Doctors based at the New York Downtown Hospital, have been given the go-ahead to begin screening women to undergo the first womb transplant in the US. The procedure will involve the removal and transferral of a uterus from a dead donor to a female recipient. After waiting three months, the recipient's own IVF embryo, previously frozen, will be introduced. If the implantation and ensuing pregnancy is successful, it is planned that the child will be delivered by Caesarean section to reduce the risk of complications. The uterus would then be removed and discarded to minimize the chances of tissue rejection. The procedure has been initially approved by the New York Downtown Hospital ethics board, which will reconsider its position after the first female patient is chosen.

Dr Giuseppe Del Priore, who is leading the New York team, said, 'The desire to have a child is a tremendous driving force for many women. We think we could help many women fulfil this very basic desire', he added. Womb transplants may provide fertility solutions for women who have had their wombs removed or damaged, and for whom IVF would not otherwise be an option. If proven safe and effective, the procedure may add to the reproduction choices of women and couples, offering an alternative to surrogacy. 'I think patients deserve autonomy', said Alan De Cherney, a fertility expert speaking on behalf of the American Society of Reproductive Medicine. 'As long as they know all the facts, it should be their choice'.

The world's first human womb transplant was performed in Saudi Arabia in 2000, but was not reported until 2002. Doctors at the King Fahad Hospital and Research Center in Jeddah transplanted a healthy womb from a 46-year old living donor into a 26- year old woman who had previously undergone a hysterectomy. The recipient required ten days of intensive immunosuppressive drug therapy to prevent the donated womb from being rejected, and it was ultimately removed after 99 days because of a blood clot. Nevertheless, the team hailed the operation as a technical success. The team in New York has been testing the procedure in rats, pigs, rabbits and hope to attempt a pregnancy in a rhesus monkey. The results have shown that a womb is able to be removed from a dead donor, reducing problems associated with blood clotting.

Some commentators have criticised the announcement, highlighting safety and ethical concerns. 'It is the convergence of two fields [organ transplantation and assisted reproduction] that are already embedded in large ethical disputes', said Lori Andrews, a bioethicist at the Chicago-Kent School of Law. 'This represents the worst of both worlds'. And other experts have cast doubt on the safety of such a procedure. 'At any time during the nine months of pregnancy it could very easily reject, and if a pregnant uterus rejects you have got a serious medical problem', said Dr Sherman Silber, a US fertility expert.

Last September, doctors at Hammersmith Hospital, London, claimed they were two years away from performing the first successful womb transplantation. For now it seems the race is on.

First womb transplant in US planned
Boston Globe |  16 January 2007
New York Team To Attempt First U.S. Uterus Transplant, Raises Ethical Concerns
Kaiser Network |  17 January 2007
US doctors plan womb transplant
BBC News Online |  17 January 2007
16 July 2012 - by Dr Victoria Burchell 
A charity has been launched to raise money for research that could allow the first womb transplants in the UK...
30 August 2011 - by Dr Charlotte Maden 
Researchers in Finland have discovered a genetic mutation potentially involved in the formation of uterine fibroids. Fibroids are the most common reason for hysterectomy, and 60 percent of women develop them before the age of 45...
22 October 2009 - by Antony Starza-Allen 
Doctors say the first successful womb transplant may be performed within two years. Research on rabbits has shown that it is possible to transplant a uterus and provide a reliable blood supply so that the organ lasts long enough to enable a pregnancy....
11 September 2006 - by Antony Starza-Allen 
Doctors at Hammersmith Hospital, London, aim to carry out the first successful womb transplant within two years, reported the Evening Standard. Doctors say that the womb would be taken from a dead donor and will only remain in the recipient for two or three years, or until...
3 July 2003 - by BioNews 
BioNews reporting from ESHRE conference, Madrid: Scientists from the Sahlgrenska Academy at Goteborg University in Sweden have announced that they have successfully achieved births from mice that had undergone uterus transplants. The research was reported at the European Society of Human Reproduction and Embryology annual conference in Madrid, Spain, and...
27 August 2002 - by BioNews 
Scientists from Goteborg University in Sweden have announced that they have successfully achieved pregnancies in mice that had undergone uterus transplants. The research is reported in the Journal of Endocrinology. Dr Mats Brannstrom and his colleagues transplanted uteruses into other mice, placing them alongside their existing uteruses in order to...
11 March 2002 - by BioNews 
Doctors in Saudi Arabia reported last week that they had performed the world's first human uterus transplant, raising hopes for childless couples whose only chance of a baby might be to use a surrogate. The operation was regarded by the doctors as successful and 'encouraging', despite the fact that complications...
to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions

Syndicate this story - click here to enquire about using this story.