Page URL:

Final human chromosome mapped

29 May 2006
Appeared in BioNews 360

After 10 years of work, 150 British and American scientists have completed a genetic map of human chromosome one, the largest of the 23 bundles of genetic material in the human body. Chromosome one makes up about eight per cent of the total human genome, and contains about twice as many genes as an average-sized chromosome - if it were typed out, say the scientists, the genetic information on chromosome one would cover 60,000 pages. The scientists have published their findings in the journal Nature.

An international consortium unveiled the final version of the entire human genome on 14 April 2003. They found that it is made of 2.9 billion base-pairs (chemical 'letters') of DNA, and contains an estimated 25-30,000 different genes. Researchers have since been looking at each of its 24 different chromosomes in detail, to identify the 'coding' stretches of DNA that make up these genes. They have also been filling gaps - stretches of DNA sequence that could not easily be determined - and double-checking for any errors.

Chromosome 1 has been found to contain 3,141 genes and genetic mutations of these genes have been found to have links to over 350 illnesses, including cancer, Alzheimer's and Parkinson's disease - making it the most gene dense chromosome in the human body. Also, according to the press release, the sequence of Chromosome one has enabled the scientists to identify more than 1000 new genes and is 'expected to help researchers find novel diagnostics and treatments for many diseases'.

Dr Simon Gregory, who headed the sequencing project at the Wellcome Trust Sanger Institute in Cambridge, UK, said that 'this achievement effectively closes the book on an important volume of the Human Genome Project, which was started in 1990 to identify the genes and DNA sequences that provide a 'blueprint' for human beings'. Dr Mark Walport, Director of the Wellcome Trust, said that 'the completion of the project, with the publication of the Chromosome 1 sequence, is a monumental achievement that will benefit the research community for years to come and is a credit to all involved'.

Final genome 'chapter' published
BBC News Online |  18 May 2006
Genome Doesn't Start With 'G' - Study of the Largest and Last Chromosome of the Human Genome Published
Medical News Today |  17 May 2006
The DNA sequence and biological annotation of human chromosome 1
Nature |  18 May 2006
27 November 2006 - by Dr Laura Bell 
New research from 13 different research centres in Britain and the US has revealed an unsuspected amount of variation between each individual's DNA. The research, published simultaneously in the journals Nature, Nature Genetics and Genome Research gives a much more comprehensive picture of human genetic variation...
21 March 2005 - by BioNews 
Researchers lead by a team at the UK's Wellcome Trust Sanger Institute have published a detailed analysis of the human X-chromosome, one of the two chromosomes that determines sex. An accompanying study uncovered the surprise finding that women have two active copies of many X-chromosome genes. Previously, scientists believed that...
21 October 2004 - by BioNews 
The 13-year project to read the entire genetic code of a human being is now complete, say the scientists involved. A detailed analysis of the final human genome 'gold standard' sequence appears in the latest issue of the journal Nature. Surprisingly, it reveals that the estimated number of genes...
23 October 2003 - by BioNews 
UK scientists have finished an in-depth study of chromosome six, the seventh human chromosome to be analysed in detail. The team, from the Wellcome Trust Sanger Institute in Cambridge, say the chromosome is made up of nearly 167 million base-pairs - chemical 'letters' of DNA - which means that it accounts for...
to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions

Syndicate this story - click here to enquire about using this story.