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South Korean stem cell pioneer resigns

24 November 2005
By BioNews
Appeared in BioNews 336

Woo Suk Hwang - head of the South Korean team that obtained the world's first embryonic stem cells (ES cells) from cloned human embryos - has quit his public positions after admitting that some eggs used in the work were provided by junior researchers and paid donors. The shock resignation follows a statement last week by US scientist Gerald Schatten, in which he ended his 20 month collaboration with Hwang over the allegations.

In a press conference given on 24 November, Hwang announced his resignation from all his official positions, including chair of the recently launched World Stem Cell Hub. 'I sincerely apologise for having stirred concern at home and abroad', he told reporters. He said that he had found out late last year that two female team members had donated eggs for his team's ground-breaking research, which was published in the journal Science early in 2004. But Hwang chose not to make this information public: 'After serious consideration, I finally chose to protect my researcher's privacy. I could have been wiser', he admitted. Hwang also said that the head of a hospital who supplied eggs for the project told him last month that some donors had been paid, despite the fact that the Science article had said no women were paid to donate eggs.

The journal Nature first raised concerns over the origin of the 247 eggs used in the research in May 2004. It claimed that PhD student Ja Min Koo originally said that the donors had included herself and another woman who worked in Hwang's laboratory. However, the journal also stated that she later called back, to say she had not donated eggs, 'blaming her poor English for a misunderstanding'.

The issue resurfaced following a police investigation of Hwang's collaborator Sung-il Roh, a fertility specialist at MizMedi Hospital in Seoul. It emerged that Roh paid some women 1.5 million won (around £840) to donate eggs to the project, which he said was compensation for the inconvenience of being hospitalised and having hormone injections for the 15-day long procedure. Although paying women to donate eggs has been outlawed in South Korea since the beginning of this year, it was still legal at the time the donations were made.

Last Tuesday, the Seoul-based television channel MBC revealed that at least one of Hwang's researchers had donated eggs for the work. In an interview with MBC, Hwang said that junior scientists had asked him about donating eggs to the project, and that he was 'very moved' by the offers. But he added that to avoid misunderstandings, he persuaded them 'on several occasions' that it would be better to work with the eggs the team had, even if there weren't enough. It now appears that the women donated their eggs without his permission, using false names.

Hwang says he has resigned from all his public posts as a way of seeking 'repentance', but will continue with his work at Seoul National University. 'Being too focused on scientific development, I may not have seen all the ethical issues related to my research', he said. UK researchers have said the episode highlights the need for strong regulatory oversight of the field, as provided by the Human Fertilisation and Embryology Authority. Biologist Robin-Lovell Badge, of the National Institute for Medical Research said: 'the excellent research carried out by Hwang and his team must continue, but in a way that considers the ethics in an appropriate way'.

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Hwang Woo-suk resigns from all official positions
The Korea Herald |  24 November 2005
S Korea cloning pioneer disgraced
BBC News Online |  24 November 2005
27 March 2006 - by BioNews 
Seoul National University (SNU) has announced it will dismiss the discredited South Korean scientist Woo Suk Hwang, for his involvement in fabricating data during his work on human embryonic stem (ES) cells. Six other professors and co-authors on two Science papers published by the group - now formally retracted - will not...
13 February 2006 - by BioNews 
Seoul National University (SNU) has suspended the discredited South Korean scientist Woo Suk Hwang and six other professors in his team from their teaching and research posts. The scientists have yet to be formally punished by SNU, for faking data and breaching ethical standards in their work on human embryonic...
3 February 2006 - by BioNews 
South Korea's national bioethics committee has produced a report on the 'serious ethical problems' with the donated human eggs used in the recently discredited stem cell research carried out by Woo Suk Hwang and his team. Korea's National Bioethics Board (KNBB) says that the scientists, based at Seoul National University...
12 January 2006 - by BioNews 
The panel investigating the work of South Korean scientist Woo Suk Hwang has reported that further research published by his team was faked. The scientists, based at Seoul National University (SNU), claimed in 2004 that they had created the world's first embryonic stem (ES) cell line from a cloned human...
7 January 2006 - by BioNews 
An investigation into the work of South Korean stem cell scientist Woo Suk Hwang and his team has concluded that they did not create any cloned embryo stem (ES) cell-lines genetically-matched to patients, as reported in their much-feted Science paper of last year. The revelations have sent shockwaves through the...
21 November 2005 - by BioNews 
The future of an international consortium aiming to advance human embryo stem (ES) cell research is looking increasingly uncertain, following allegations that its South Korean head, Woo Suk Hwang, used eggs donated by a junior researcher to create cell lines. On 12 November, Gerald Schatten, from Pittsburgh University in the...
14 November 2005 - by BioNews 
A leading American stem cell researcher has abruptly ended his 20 month long collaboration with the team of South Korean scientists famous for creating the world's first human embryonic stem (ES) cell lines from cloned embryos. The same team announced in May that it had managed to derive the world's...
20 October 2005 - by BioNews 
An international consortium headed by South Korean stem cell scientist Woo Suk Hwang has announced the establishment of the World Stem Cell Hub. The consortium has set up an international bank of human embryonic stem (ES) cell lines at Seoul National University, which will have satellite laboratories in England, and...
5 August 2005 - by BioNews 
After much patience and perseverance, dogs can now officially be added to the list of animals, including sheep, cats and horses, that have been successfully cloned. Researchers in South Korea led by Professor Woo Suk Hwang - the team that created the world's first cloned human embryos - have cloned an Afghan...
6 June 2005 - by BioNews 
Woo Suk Hwang - head of the team that announced the creation of 11 patient-specific embryonic stem (ES) cell-lines recently - is planning to open an international stem cell bank in South Korea. The bank would mean that all existing human ES cell-lines would be in one place, enabling doctors to identify...
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