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Second frozen ovary transplant birth

1 July 2005
By BioNews
Appeared in BioNews 315

An Israeli woman has given birth to a healthy baby girl after undergoing an ovarian tissue transplant, following cancer treatment that left her infertile. The 28-year-old woman, treated at the Sheba Medical Center in Tel Hashomer, is only the second patient in the world to have given birth after such an operation. Dror Meirow and Jehoshua Dor reported the pregnancy at the recent annual meeting of the European Society of Human Reproduction and Embryology (ESHRE), and the case has now been published online in the New England Journal of Medicine.

Last year, Belgian doctors reported the birth of the world's first baby conceived following an ovary transplant, but there was no way of proving that the pregnancy was not the result of residual fertility. However, the Israeli team that reported the latest case say they are confident the patient had experienced complete ovarian failure prior to the transplant, and had begun early menopause. 'There's absolutely no doubt in this case', commented fertility expert Francoise Shenfield, of University College London.

The woman had already begun a mild round of chemotherapy treatment before having ovarian tissue removed and frozen. Two years after completing chemotherapy, the doctors attached strips of her frozen ovarian tissue to her left ovary, and fragments of tissue injected into the right ovary. After nine months, she resumed menstruation, and the team removed an egg from her left ovary, fertilised it with her husband's sperm, and implanted the resulting embryo into the woman.

The doctors say that although they cannot rule out the possibility that the egg came from the remaining ovary tissue, it is 'very unlikely' because of the timing of the pregnancy and tests showing that the woman had been consistently infertile before the transplant. Commenting on the news when it was reported at the ESHRE conference, Simon Davies, chief executive of the Teenage Cancer Trust said that 'this option should now be offered to women and teenage girls - in fact to any woman capable of understanding what it involves and making an informed decision', adding 'unless there are risks, the question has to be "why not?"'

The Belgian team that reported the birth of the world's first ovary transplant baby, Tamara Touriat, say they have successfully carried out another ovarian tissue transplant. At a conference held earlier this year, they revealed that the 28-year old woman - who had ovarian tissue removed in 1999 before undergoing radiotherapy for sickle-cell anaemia - has started to menstruate again after the operation. However, the woman has not yet become pregnant.


Birth from frozen ovarian tissue reported
Yahoo Daily News |  27 June 2005
Doctors demand ovary banks for cancer patients
The Times |  22 June 2005
Frozen ovary yields healthy baby
Nature News |  28 June 2005
9 July 2007 - by Danielle Hamm 
Israeli scientists are reported to have extracted, matured and frozen eggs from young girls affected by cancer. Although it is too early to tell whether they are viable, it is hoped that the frozen eggs will one day offer young cancer patients the chance to have a...
6 January 2006 - by BioNews 
New European rules on the use and storage of human tissue could deny young British women undergoing cancer treatment the chance to preserve their fertility, according to a report in the Times newspaper. The requirements of the new EU Tissues and Cells Directive make it prohibitively expensive for many centres...
1 July 2005 - by BioNews 
Doctors in Scotland have come up with a way of predicting when a woman may become sterile after undergoing radiation therapy as part of cancer treatment, according to a study published in the International Journal of Radiation Oncology. The researchers developed a formula that takes into account the age of...
21 March 2005 - by BioNews 
Researchers at the University of Louvain in Brussels, Belgium, say that a second woman there has had a successful ovarian tissue transplant. The 28-year old woman - who had ovarian tissue removed in 1999 before undergoing radiotherapy for sickle-cell anaemia, a treatment that can render women infertile - has started to...
8 November 2004 - by BioNews 
Doctors at Leiden University Hospital in the Netherlands have announced success in fertility preservation. They have successfully transplanted a woman's whole ovary into her arm in order to save her fertility while she undergoes cancer treatment. The operation took place two years ago but the details are only just about...
27 September 2004 - by Dr Jess Buxton 
This week, BioNews reports on the world's first baby born following a transplant of frozen, thawed ovary tissue. This is the first success for a technique that promises to benefit thousands of women who would otherwise lose their fertility forever. Ouarda Touriat, who underwent lifesaving cancer treatment that left her...
25 September 2004 - by BioNews 
The first woman in the world to become pregnant following a transplant of her own frozen, thawed ovarian tissue has given birth to a healthy baby girl. In 1997, Ouarda Touirat, now aged 32, had parts of her ovaries removed before beginning treatment for Hodgkin's lymphoma that would leave her...
29 June 2004 - by BioNews 
BioNews reporting from the ESHRE conference, Berlin: Danish researchers have reported that they are on the verge of producing a pregnancy from frozen-thawed human ovarian tissue, while in Belgium it transpires that a woman is already 25 weeks pregnant following similar treatment - the first time this treatment has ever led...
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