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Embryo stem cells help treat paralysed rats

13 May 2005
By BioNews
Appeared in BioNews 308

US scientists have successfully treated rats with spinal cord injuries, using cells derived from human embryonic stem cells (ES cell). The team, based at the Reeve-Irvine Research Center at the University of California, Irvine, reports that the cells restored movement in rats treated seven days after the initial injury, but did not work on rats that had been injured for ten months. The researchers say that their findings, published in the Journal of Neuroscience, offer hope for treating patients during the very early stages of spinal cord injury.

Many researchers think that ES cells, which have the potential to grow into almost any type of cell, hold great promise for treating a range of serious medical conditions. The Irvine team, who presented preliminary results from the study at a conference two years ago, used ES cells to grow specialised 'nerve insulating' cells, called oligodendrocytes. These cells form myelin, the substance that covers and insulates nerve cell fibres, in the same way that plastic insulates electrical wires. If nerve cells lose their myelin covering through disease or injury, then the patient can lose sensory or movement ability, leading to paralysis if the spinal cord is severely affected.

The scientists injected the human ES cell-derived oligodendroctyes into rats that had experienced a partial spinal cord injury, which meant they could no longer walk properly. They treated one group seven days after the injury, and another group ten months after the damage had been sustained. In the rats treated after seven days, myelin formed around the damaged nerve cells in the spinal cord, and within two months the animals showed 'significant improvements' in walking ability, compared to untreated rats. However, there was no such improvement in the rats treated after ten months, because although the transplanted cells survived, myelin could not form due to the scar tissue that had grown around the damaged nerves.

Team leader Hans Keirstead says the group are 'very excited' with the results, which highlight the importance of myelin loss in spinal cord injury. 'This study suggests one approach to treating people who've just suffered spinal cord injury, although there is still much work to do before we can engage in human clinical tests', he said. It is thought that stem cell treatments in humans could be given during the first few weeks following injury, when rods and ties are placed in the spinal column to stabilise it.

Geron Announces Publication of Studies Showing Oligodendrocyte Progenitors Derived From Human Embryonic Stem Cells Induce Functional Recovery After Spinal Cord Injury
Genetic Engineering News |  10 May 2005
Stem cell treatment improves mobility after spinal cord injury
Medical News Today |  11 May 2005
Study gives hope to spinal patients
The Daily Mail |  10 May 2005
24 June 2006 - by Heidi Nicholl 
A team from Johns Hopkins University School of Medicine has managed to partially restore movement in paralysed rats using mouse embryonic stem cells (ES cells)and a cocktail of chemical enhancers. Research leader Douglas Kerr described the work as 'a blueprint for how to rewire part of the...
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30 March 2006 - by BioNews 
Canadian researchers have used a cocktail of stem cells, growth hormones and anti-inflammatory drugs to treat rats with spinal injuries. The team, based at the Toronto Western Research Institute, say that the treatment restored some walking ability and limb control in the animals. The research, published in the Journal of...
21 September 2005 - by BioNews 
US scientists have used nerve stem cells to treat mice affected by severe spinal cord injuries. The team, based at the University of California at Irvine, said the treated animals regained the ability to walk just a few weeks after receiving the injections. The findings, published in the Proceedings of...
4 July 2003 - by BioNews 
Two new studies carried out using rats have shown that stem cells taken from early embryos could be used to treat spinal injuries. Researchers at the University of California in Irvine, US, used stem cells from human embryos to grow specialised 'nerve insulating' cells to successfully treat paralysed rats with...
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