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Ovary transplanted to arm stays functional

8 November 2004
By BioNews
Appeared in BioNews 283

Doctors at Leiden University Hospital in the Netherlands have announced success in fertility preservation. They have successfully transplanted a woman's whole ovary into her arm in order to save her fertility while she undergoes cancer treatment. The operation took place two years ago but the details are only just about to be published, in the December edition of the journal Cancer.

The woman, who was 29 years old, had cervical cancer. While surgery for cervical cancer can improve the chance of survival, it can also cause early and permanent ovarian failure. In an attempt to prevent this, doctors removed one of the woman's ovaries while carrying out surgery for the cancer, and transplanted it to her left upper arm. The arm is thought to be a good place for transplants of this sort, as it allows the ovary to be kept intact and keeps it well supplied with blood. In this case, the ovary retained its function and ovulated every month - the eggs were absorbed into the surrounding tissue. If the woman had wanted to have children, IVF procedures could have been used to harvest eggs from the ovary. Unfortunately, the woman's cancer returned, and she died recently.

The procedure will add to the growing list of techniques used to try and preserve the fertility of women when they undergo cancer treatment. This transplant would not work if the woman were undergoing chemotherapy, however, but the principles involved in the procedure show that it may be feasible to remove intact ovaries from women before they begin treatment and transplant them back to the arm when it is finished.

Recently, Belgian doctors reported a successful pregnancy using slivers of ovary that had been removed from a woman before cancer treatment and frozen, then thawed and grafted back into her when her health recovered. This produced the first birth using this technique. Previously some women had been able to restore their menstrual cycle, but none had succeeded in becoming pregnant. 'This is a very powerful new procedure', said Dr Carina Hilders, a member of the team which carried out the latest study. She added: 'It is the first time anyone has successfully transplanted an entire ovary into another part of the body and preserved its functions'.

Cancer victim's ovary is kept safe in her arm
The Sunday Times |  7 November 2004
Doctors transplant ovary to woman's arm to preserve fertility
EurekaAlert |  8 November 2004
'Ovary-arm' transplant a success
BBC News Online |  8 November 2004
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3 October 2005 - by BioNews 
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21 March 2005 - by BioNews 
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This week, BioNews reports on the world's first baby born following a transplant of frozen, thawed ovary tissue. This is the first success for a technique that promises to benefit thousands of women who would otherwise lose their fertility forever. Ouarda Touriat, who underwent lifesaving cancer treatment that left her...
25 September 2004 - by BioNews 
The first woman in the world to become pregnant following a transplant of her own frozen, thawed ovarian tissue has given birth to a healthy baby girl. In 1997, Ouarda Touirat, now aged 32, had parts of her ovaries removed before beginning treatment for Hodgkin's lymphoma that would leave her...
29 June 2004 - by BioNews 
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