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Stem cells can rebuild heart muscle

2 April 2001
By BioNews
Appeared in BioNews 101

Two teams of scientists have made independent breakthroughs using stem cells to repair cardiac muscles damaged by heart attacks. They have shown in experiments on mice that heart muscle can repair after injections of stem cells. The stem cells used in the experiments were derived from the bone marrow of adult mice or taken from human volunteers and have shown the first unequivocal results that adult stem cells (rather than embryonic stem cells) are capable of repairing cardiac tissue.

The team that used the human stem cells are from Columbia University in New York, led by Silviu Itescu. A team led by Donald Orlic of the US National Human Genome Research Institute and Piero Anversa of New York Medical College transplanted adult stem cells taken from mice. Dr Orlic said that more than two-thirds of the damaged sites were 'invaded' by the injected stem cells. This caused some of the cardiac muscle and oxygen-supplying blood vessels to regenerate.

On the potential of adult stem cells Dr Anversa said 'our results indicate the great potential of adult stem cells to differentiate into other cell types and repair a damaged organ, a property commonly attributed to embryonic stem cells. This may allow us to utilise a patient's own stem cells'.

The findings of the studies has surprised the scientists as the evidence was beyond their expectations, showing that the damage caused by heart attacks could be reversed. It is now hoped that clinical trials on human heart attack victims will begin within three years.

Marrow transplant hope for heart patients
The Guardian |  31 March 2001
Scientists repair damage from heart attack using adult bone marrow stem cells in mice
ScienceDaily magazine |  2 April 2001
Stem cells repair heart attack damage
BBC News Online |  31 March 2001
18 March 2019 - by Caroline Casey 
The Lancet has retracted a 2011 paper reporting clinical trial data using cardiac stem cells isolated by Dr Piero Anversa's former laboratory...
5 November 2018 - by Shaoni Bhattacharya 
A US government agency has 'paused' a trial of stem cell treatment for heart failure following calls for 31 scientific papers to be retracted...
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