Page URL: https://www.bionews.org.uk/page_157604

Childhood obesity linked to genomic instability which is a hallmark of most cancers

5 July 2021
Appeared in BioNews 1102

Obese children and adolescents experience higher levels of genomic instability, potentially increasing the risk of cancer in adulthood, a study has shown.

Genomic instability can lead to an increased rate of DNA mutation in a cell and therefore a higher likelihood of cancer development. Researchers at the University of Westminster, London, worked in collaboration with doctors at King's College Hospital, London, and St George's Hospital, London, to analyse a variety of measurements from individuals with and without obesity to develop a new approach for predicting genomic instability.  

First author Dr Moonisah Usman, of the University of Westminster said: 'The study involved 132 children and adolescents aged 1018 and used quantitative measurements of the body composition of participants including BMI Z-score, waist and hip circumference, and body fat percentage. Inflammation and vitamin D levels in saliva and DNA damage through urine and cheek swab samples were also assessed to score for genomic instability.'

Researchers drew on previous studies that argued excess fat tissue can lead to increased inflammation and nutritional deficiencies, including vitamin D. The understanding is that these conditions could cause genomic instability, which could ultimately lead to cancer.  

The results from the cross-sectional study that recruited participants from schools and paediatric obesity clinics in London were published in the International Journal of Obesity. The researchers found that obesity, vitamin D levels and oxidative DNA damage are three significant predictors of genomic instability that, taken together, could allow for non-invasive monitoring and predictive modelling of genomic instability in young patients with obesity. 

Lead author Dr Emanuela Volpi, at the University of Westminster said: 'Predictive modelling based on these findings could assist clinicians in interpreting the significance of weight-loss interventions in children and adolescents, and support them with prioritising the provision of further clinical measures to help reduce the risk of cancer later in life.'

These findings could help to assess the risk for young individuals with obesity to develop cancer in later life, and help target efforts to reduce the risk of cancer. 

SOURCES & REFERENCES
Genomic instability linked to cancer is more likely in children and adolescents with obesity, study finds
Medical Xpress |  3 December 2021
Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents
International Journal of Obesity |  22 June 2021
RELATED ARTICLES FROM THE BIONEWS ARCHIVE
19 April 2021 - by Anna Wernick 
A twin study has revealed that obesity causes the dysfunction of mitochondria which triggers inflammation, particularly in fat tissue...
26 May 2020 - by Georgia Everett 
According to preliminary research, scientists may have found a gene that explains why some individuals naturally stay slim...
9 December 2019 - by Dr Melanie Krause 
For the first time US researchers have shown that not only genetics but a different level of developmental regulation called epigenetics impacts the innate drive of mice to exercise...
25 November 2019 - by Eleanor Mackle 
Dr Giles Yeo at the University of Cambridge is on a mission to change the common conception that obesity is a choice...
HAVE YOUR SAY
to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions


Syndicate this story - click here to enquire about using this story.