Page URL: https://www.bionews.org.uk/page_143531

Postdoc (Anatomy and Embryology)

Address: Leiden, The Netherlands
Salary: Maximum €5,226 gross per month

Job vacancy number: D.19.NR.CV.39

Deadline for applications: 18 August 2019

The position

Are you interested in gene editing of X and Y chromosomes and how this influences the sex differentiation of human pluripotent stem cells? Then this postdoc position might be something for you.

Your main tasks will be gene editing of specific genes (on the X and Y chromosome) using CRISPR/Cas technology and tissue culture of human pluripotent stem cells. You will then screen the stem cells for the introduced gene mutations and differentiate those to germ cells. You will also use other cellular and molecular techniques (FACS, qPCR, microscopy, immunofluorescence).

The profile

You are a motivated and experimentally talented colleague who:

  • Holds a PhD and is familiar with molecular biological research.

  • Is very experienced in developing and using gene editing (CRISPR/Cas) tools.

  • Is interested in gametogenesis and sex chromosomes.

The offer

You will be employed on the basis of a 36-hour week. Appointment is initially for one year, with possible extension. Your salary is based on your education and experience and is a maximum of €5,226 gross per month based on a full time position (scale 11 of the Collective Labour Agreement for University Hospitals).

Working at LUMC

The Leiden University Medical Centre (LUMC) is a centre for medical innovation that aims to improve patient care through leading international research. So as to also provide our patients with a safe and friendly environment, we need doctors, medical care specialists, support staff and academic researchers.

The appointment is within the Anatomy and Embryology department. In this project (VICI) we want to discover genes that are important for the development of male and female germ cells and the mechanisms that underlie the development of ova and sperm cells from human pluripotent stem cells. In our group we often work with abortion material. Human ovary material is also used.

More information

A detailed description of this position can be found here. If you have any questions or would like more information about this position, please contact Susana M Chuva de Sousa Lopes (Associate Professor, Department of Anatomy and Embryology) on +31(0) 71 526 93 50.

References can be requested and an assessment will be part of the procedure.

How to apply

If you are interested in this position, please complete this application form by Sunday 18 August 2019 at the latest.