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Mitochondrial donation
Also known as Mitochondrial Replacement Therapy (MRT) in some territories, mitochondrial donation allows an embryo to be created using the nuclear DNA of the intended parents, but using mitochondria (including mitochondrial DNA) from a donor egg or embryo.
The procedure was developed to allow women with mitochondrial mutations have genetically related children while to avoiding passing on mitochondrial disease.
Several techniques exist, including maternal spindle transfer (MST) where the nucleus is transferred from the mother's egg to an enucleated donor egg and then fertilised, and pronuclear transfer, where the nuclear material is transferred after fertilisation has taken place.
Articles using this Glossary Item
| Gender Based Prohibitions in the Human Fertilisation and Embryology Act | 8 March 2021 | Comment |
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| Ethics of genetically reconstituting oocytes | 1 March 2021 | Comment |
| Australia announces conscience vote on mitochondrial donation | 8 February 2021 | News |
| Book Review: We Are Family – What really matters for parents and children | 9 November 2020 | Review |
| Obituary: Frank Dobson, the politician pivotal to PET | 18 November 2019 | News |
| Event Review: Transforming Medicine - The Promise of Human Genome Editing for Rare and Genetic Disease | 16 September 2019 | Review |
| Is the UK fertility sector facing a tipping point? | 8 July 2019 | Comment |
| DNA study may have implications for mitochondrial donation | 3 June 2019 | News |
| US scientists push for mitochondrial donation legalisation | 29 April 2019 | News |