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Mitochondrial donation

Also known as Mitochondrial Replacement Therapy (MRT) in some territories, mitochondrial donation allows an embryo to be created using the nuclear DNA of the intended parents, but using mitochondria (including mitochondrial DNA) from a donor egg or embryo.

The procedure was developed to allow women with mitochondrial mutations have genetically related children while to avoiding passing on mitochondrial disease.

Several techniques exist, including maternal spindle transfer (MST) where the nucleus is transferred from the mother's egg to an enucleated donor egg and then fertilised, and pronuclear transfer, where the nuclear material is transferred after fertilisation has taken place. 

Articles using this Glossary Item

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Is the UK fertility sector facing a tipping point? 8 July 2019 Comment
DNA study may have implications for mitochondrial donation 3 June 2019 News
US scientists push for mitochondrial donation legalisation 29 April 2019 News

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