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Off-target effects

Unintended changes to a genome, away from the desired target site, which occur as a consequence of genome editing.

Articles using this Glossary Item

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Mice produced from unfertilised eggs 14 March 2022 News
Jailed scientist Dr He Jiankui should be made 'responsible' for children whose genomes he edited 7 March 2022 News
Event Review: Modifying Humans – Is global governance of genome editing possible? 17 January 2022 Review
RNA-based control switch could be used to turn on gene therapies in cells 8 November 2021 News
New method giving insight into DNA repair pathways could improve genome editing 25 October 2021 News
Prenatal base editing corrects lysosomal storage disease 19 July 2021 News
Researchers warn of unintended effects from CRISPR genome editing 19 April 2021 News
Base editing offers hope for child ageing disease 11 January 2021 News
New study on CRISPR: the stake of unintended consequences in embryos 23 November 2020 Comment
Podcast Review: Mapping Humanity – How modern genetics is changing criminal justice, personalised medicine, and our identities 21 September 2020 Review
CRISPR genome editing improved by enzyme testing 14 September 2020 News
New report gives guidance on genome editing for heritable diseases 7 September 2020 News
Genome editing in human embryos has unintended side-effects 29 June 2020 News
CRISPR can now target RNA - including coronavirus genome 23 March 2020 News
New Cas9 variant reduces off-target CRISPR effects 9 March 2020 News
Stem cell therapy cures diabetes in mice 2 March 2020 News
Event Review: The Gene Gap – Who would you trust to edit the human race? 17 February 2020 Review
Improved base-editors advance CRISPR based genome editing 17 February 2020 News
CRISPR-edited cells for cancer treatment appear safe 10 February 2020 News
Chinese scientist who created genome-edited babies jailed 6 January 2020 News
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Events using this Glossary Item

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