Page URL: https://www.bionews.org.uk/page_137189

Gene therapy reverses type 2 diabetes in mice

16 July 2018
Appeared in BioNews 958

Gene therapy has been used in mice to successfully reverse obesity and insulin resistance, as well as other markers of type 2 diabetes.

Researchers introduced the gene FGF21 into obese mice via an adeno-associated virus. They found that this had a long-term impact, leading to weight loss and reduced insulin resistance in the animals for over a year, noting no side effects.

'This is the first time that long-term reversion of obesity and insulin resistance have been achieved upon a one-time administration of a gene therapy, in an animal model that resembles obesity and type 2 diabetes in humans,' said the first author of the study Dr Veronica Jimenez at Universitat Autònoma de Barcelona in Spain. The research was published in EMBO Molecular Medicine.

The therapy worked on two different mouse models of obesity, in which the mice were obese either through their diet or through genetic modification. The scientists also found similar results when introducing the gene into one of several different tissues - liver, skeletal tissue or adipose tissue.

'This gives a great flexibility to the therapy since it allows [us] to select each time the most appropriate tissue, and in case some complication prevents manipulating any of the tissues, it can be applied to any of the others,' said Professor Fatima Bosch, who led the study. 'When a tissue produces FGF21 protein and secretes it into the bloodstream, it will be distributed throughout the body.'

As well as the effects in obese mice, the researchers found that introducing FGF21 in the same way in healthy mice reduced age-related weight gain and promoted healthy ageing.

'The results demonstrate that it is a safe and effective therapy,' said Dr Jimenez.

The next steps will be to 'test this therapy in larger animals before moving to clinical trials with patients', said Professor Bosch.

SOURCES & REFERENCES
FGF21 gene therapy as treatment for obesity and insulin resistance
EMBO Molecular Medicine |  9 July 2018
Gene therapy shown to cure type 2 diabetes and obesity in mice, researchers report
Science Daily |  9 July 2018
Pioneering gene therapy found to reverse type 2 diabetes in mice
Diabetes.co.uk |  17 November 2019
Type 2 diabetes, obesity may soon be reversed with gene therapy
Medical News Today |  12 July 2018
RELATED ARTICLES FROM THE BIONEWS ARCHIVE
23 July 2018 - by Isobel Steer 
Gene therapy has successfully treated a disorder in mice while still inside the womb, according to a study published in Nature Medicine...
8 January 2018 - by Isobel Steer 
A gene therapy has been used to restore normal blood sugar levels in mice with type 1 diabetes, according to a study published this month in the journal Cell Stem Cell.
20 November 2017 - by Charlott Repschlager 
A rare genetic mutation leading to longer and healthier lives has been discovered in the US Amish community...
25 September 2017 - by Sarah Gregory 
A novel gene therapy can reverse the symptoms and progression of disease in a mouse model of multiple sclerosis...
HAVE YOUR SAY
Log in to add a Comment.

By posting a comment you agree to abide by the BioNews terms and conditions


Syndicate this story - click here to enquire about using this story.