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Babies born through IVF have higher cancer rates

02 May 2017

By Dr Rachel Brown

Appeared in BioNews 898

Children born through IVF are at an increased risk of some childhood cancers, suggests a new study.

The incidence of childhood cancers was almost three times higher in in children born to mothers who had used IVF compared with those who were conceived spontaneously. The difference was 1.5 per 1000 compared with 0.59 per 1000 children, according to the paper which was published in the American Journal of Obstetrics and Gynecology.

'The association between IVF and total paediatric neoplasms and malignancies is significant,' co-author Professor Eyal Sheiner at Ben-Gurion University of the Negev, Israel, told the Daily Mail. 'With increasing numbers of offspring conceived after fertility treatments, it is important to follow up on their health.'

Israeli researchers monitored about 242,000 children born between 1991 and 2013 until they were 18. Of this group: 98.3 percent had been conceived spontaneously, 1.1 percent were conceived following IVF, and 0.7 percent were conceived after ovulation induction treatments. During the study's median follow-up of 10 and a half years, a total of 1498 or 0.6 percent of the children were diagnosed with a form of paediatric cancer, such as leukemia, brain and spinal cord tumours, and lymphoma.

The paediatric cancer rate was also higher in children born following ovulation induction treatments compared with those born after natural conception, at 1.0 per 1000 compared with 0.59 per 1000 children.

The associations of childhood cancer with IVF and ovulation induction treatments were still seen after the researchers accounted for possible confounding factors including premature births or the mother's age.

However, Professor Sheiner noted that there were some limitations to the study, including that it did not examine the reasons for infertility that led to parents using IVF, nor look at the effect of environmental exposures.

This paper follows a number of studies aiming to determine whether fertility treatments affect the health outcomes of children conceived through them compared with those conceived naturally. This includes a twin study by researchers at King's College London and published recently in Genome Medicine that found no major effects of IVF on a child's epigenetics.

RELATED ARTICLES FROM THE BIONEWS ARCHIVE

17 July 2017 - by Taqdeer Sidhu 
Children conceived from donor sperm have a similar health and wellbeing to the general population, according to a recent study...

31 October 2016 - by Georgia Everett 
Seventeen children conceived through ooplasmic transplantation have all matured with regular health and cognitive abilities, according to a study...
24 October 2016 - by Lone Hørlyck 
Bearing a child at a higher age does not increase risk of birth defects when the woman has received IVF or ICSI treatment to become pregnant, a recent study suggests...
10 October 2016 - by Rikita Patel 
The first generation of men born through intracytoplasmic sperm injection (ICSI) have lower sperm counts, according to a small study...
22 February 2016 - by Ryan Ross 
The use of IVF technologies could be storing up future health problems for children born through the technique, according to an evolutionary biologist...
11 January 2016 - by Dr Katie Howe 
Children conceived using IVF and other fertility treatments are at no greater risk of developmental delays than children conceived naturally, according to a large US study...

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