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The Fertility Show, Manchester Central, 24-25 March 2018


Epigenetic sperm test sheds light on male infertility

31 October 2016

By Dr Ashley Cartwright

Appeared in BioNews 875

The US start-up Episona has produced an epigenetic sperm test, which it claims can determine whether sperm will produce 'good' or 'poor' quality embryos.

The test, named 'Seed', was unveiled at the American Society for Reproductive Medicine's annual congress in Salt Lake City, Utah, this month, but it has received a cautious reception from fertility experts.

'Physicians have long relied on the traditional semen analysis as the sole option for determining the male's role in fertility,' said Episona president and CEO, Dr Alan Horsager. '[But this] offers little insight into the more complex factors related to male fertility or into the male's role in embryo development. Seed provides patients with previously missing information about their fertility and we believe this has the potential to transform fertility care.'

The test assesses DNA methylation at 480,000 regions across a sperm cell's genome. Environmental factors can alter the patterns of methylation in the genome – not just a man's own past and present environment, but also that of his own parents or grandparents.

Episona says that the regions selected are based on known methylation differences in the DNA of fertile and infertile sperm. After analysis of all the regions, a relative risk is assigned to each 'abnormal' location for either male-factor infertility or poor embryo development.  

But Dr Brian Abraham, a postdoctoral research fellow in epigenetics at the Massachusetts Institute of Technology, has reservations about the test. 'While the link between DNA methylation and sperm success has been studied, there is currently no consensus for how epigenomes contribute to this success,' he told the Genetic Literacy Project.

Episona co-founder Dr Douglas Carrell, an endocrinologist at the University of Utah, told STAT: 'My hope for the test is that we give [couples] more knowledge beforehand … One of the most heartbreaking things we see is people go through one cycle of IVF, have poor-quality embryos, and then go through a second cycle hoping it will be better.'

However, the company's website shows that they are marketing the test as 'a male fertility test that uses epigenetic data to improve your chances to get pregnant'.


06 November 2017 - by Lea Goetz 
Men with infertility experience stigmatisation and a lack of support, a first survey on the subject found...
18 September 2017 - by Dr Kimberley Bryon-Dodd 
A type of chemical found in various personal beauty products and plastics may affect sperm and lower reproductive success, according to a new study...
31 July 2017 - by Dr Katie Howe 
Sperm counts of men in developed nations have fallen by 52 percent in the last 40 years...

10 October 2016 - by Rikita Patel 
The first generation of men born through intracytoplasmic sperm injection (ICSI) have lower sperm counts, according to a small study...
04 July 2016 - by Lone Hørlyck 
A study of smokers has found smoking damages their sperm, including their DNA and mitochondria, by triggering inflammatory processes in their semen...
11 April 2016 - by Arit Udoh 
The ultraviolet-filtering ingredients in sunscreen products interfere with the normal function of human sperm when applied to a sperm-containing solution in the lab...
29 February 2016 - by Dr Rosie Gilchrist 
Certain aspects of mobile phone usage may be linked to abnormal sperm concentration, according to research...
14 December 2015 - by Ayala Ochert 
Men who have been diagnosed with infertility have a higher risk of developing heart disease and type 2 diabetes, as well as other general health problems, including alcohol abuse and drug abuse...

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