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The Fertility Show, Manchester Central, 24-25 March 2018

Glossary

CRISPR/Cas9

A genome-editing platform that uses an enzyme (Cas9) to make a double-stranded break at a specific location in the genome, directed by a guide RNA.



Articles using this Glossary Item

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Radio review: Science in Action - CRISPR immunity

05 February 2018 - by Theofanis Michailidis

As a law graduate with a special interest in medical law and bioethics, I admit having very limited scientific background or knowledge... [Read More]

USA announces $190 million for genome editing research

29 January 2018 - by Hannah Tippett Simpson

The US National Institutes of Health (NIH) has announced its intention to grant US$190 million for genome editing research... [Read More]

Podcast Review: Naked Genetics - The Future of Genomic Medicine

22 January 2018 - by Sam Sherratt

Over the last few years we've seen a welcome explosion in the number of scientific podcasts aiming to spread the gospel about new research that may otherwise miss the attention of the mainstream media. With this in mind, I recently sat down to listen to an episode of Naked Genetics, a weekly podcast covering the 'latest genetics news and breakthroughs from the DNA world'... [Read More]

Human immune response may stymie CRISPR genome editing therapies

15 January 2018 - by Rikita Patel

The human adaptive immune response against the Cas9 protein - part of the CRISPR genome editing system – may pose a barrier to new therapies, suggests a new study... [Read More]

New CRISPR technique reverses diabetes and kidney failure in mice without cutting DNA

11 December 2017 - by Isobel Steer

Scientists in California have used a modified form of the CRISPR/Cas9 genome editing approach to epigenetically treat diabetes, kidney disease and muscular dystrophy in mice... [Read More]

Real-time film shows CRISPR in action

20 November 2017 - by Helen Robertson

For the first time ever, researchers have been able to film, in real-time, the activity of the CRISPR technique on a strand of DNA... [Read More]

Broad Institute responds to Berkeley CRISPR patent appeal

30 October 2017 - by Jennifer Willows

The Broad Institute has filed arguments ahead of the upcoming CRISPR patent appeal hearing... [Read More]

Event Review: Manchester Science Festival - Reproduction 2.0

30 October 2017 - by Laura O'Donovan

Almost forty years have passed since the 1978 birth of Louise Brown – the first IVF baby – launched a revolution in reproductive medicine resulting in over 250,000 births in the UK alone... [Read More]

New advance in DNA base editing tools

30 October 2017 - by Julianna Photopoulos

Scientists have developed the genome editing technique known as 'base editing' to turn adenine-thymine base pairs back to guanine-cytosine... [Read More]

RNA editing tools could create new disease therapies

30 October 2017 - by Dr Rachel Huddart

A new molecular tool to change individual letters in an RNA sequence may open up new possibilities for gene therapy... [Read More]

'CRISPR-Gold' repairs muscular dystrophy gene in mouse model

09 October 2017 - by Emma Laycock

Scientists have repaired the faulty gene in a mouse model of muscular dystrophy by using gold nanoparticles to deliver the genome editing tool CRISPR-Cas9... [Read More]

Genome editing targets beta-thalassemia in human embryos

02 October 2017 - by Dr Rachel Brown

A genome editing technique called 'base editing' has been used to correct the mutation causing the inherited blood disorder beta-thalassemia in human embryos... [Read More]

Video review: TED - Editing Our Evolution

02 October 2017 - by Eleanor Taylor

The latest CRISPR offering in the TED world comes from Dr Helen O'Neill, a molecular geneticist at University College London, UK. Her talk aimed to 'explore how and why the world and its inhabitants are constantly changing'... [Read More]

First genome editing of human embryos by UK scientists

25 September 2017 - by Paul Waldron

UK scientists have successfully edited the genome of human embryos to study the role of a gene key to the earliest stages of development... [Read More]

Podcast Review: The Life Scientific - Jennifer Doudna

25 September 2017 - by Rikita Patel

The new era of gene technology presents an exciting approach to treat deleterious, inherited genetic conditions. Presenter Jim Al-Khalili talks to Professor Jennifer Doudna, from her early life to her research into molecular biology, to the development of the CRISPR/Cas9 genome editing system... [Read More]

Cancer mutations explored using organoids and CRISPR

18 September 2017 - by Dr Molly Godfrey

Organoids and CRISPR/Cas9 have been combined in a novel method to study genetic mutations occurring in cancer... [Read More]

Doubt over human embryo editing study

04 September 2017 - by Annabel Slater

A group of scientists have challenged the landmark study which reported the first successful editing of human embryos for a genetic disease... [Read More]

Book Review: A Crack in Creation - Gene Editing and the Unthinkable Power to Control Evolution

21 August 2017 - by Annabel Slater

I'm glad to see a scientist engaging so strongly in public debate about the use of technology, rather than speculating on the sidelines... [Read More]

Dozens of new gene targets for cancer immunotherapy found

14 August 2017 - by Ebtehal Moussa

Over a 100 new genes that may be essential for cancer immunotherapy to work have been identified using a new CRISPR-based screen... [Read More]

Pig organ transplants a step closer as CRISPR removes viruses

14 August 2017 - by Cara Foley

Ancient viral genes have been eliminated from pigs using the genome editing tool CRISPR, according to research... [Read More]

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