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Glossary

CRISPR/Cas9

A genome-editing platform that uses an enzyme (Cas9) to make a double-stranded break at a specific location in the genome, directed by a guide RNA.



Articles using this Glossary Item

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Real-time film shows CRISPR in action

20 November 2017 - by Helen Robertson

For the first time ever, researchers have been able to film, in real-time, the activity of the CRISPR technique on a strand of DNA... [Read More]

Broad Institute responds to Berkeley CRISPR patent appeal

30 October 2017 - by Jennifer Willows

The Broad Institute has filed arguments ahead of the upcoming CRISPR patent appeal hearing... [Read More]

Event Review: Manchester Science Festival - Reproduction 2.0

30 October 2017 - by Laura O'Donovan

Almost forty years have passed since the 1978 birth of Louise Brown – the first IVF baby – launched a revolution in reproductive medicine resulting in over 250,000 births in the UK alone... [Read More]

New advance in DNA base editing tools

30 October 2017 - by Julianna Photopoulos

Scientists have developed the genome editing technique known as 'base editing' to turn adenine-thymine base pairs back to guanine-cytosine... [Read More]

RNA editing tools could create new disease therapies

30 October 2017 - by Dr Rachel Huddart

A new molecular tool to change individual letters in an RNA sequence may open up new possibilities for gene therapy... [Read More]

'CRISPR-Gold' repairs muscular dystrophy gene in mouse model

09 October 2017 - by Emma Laycock

Scientists have repaired the faulty gene in a mouse model of muscular dystrophy by using gold nanoparticles to deliver the genome editing tool CRISPR-Cas9... [Read More]

Genome editing targets beta-thalassemia in human embryos

02 October 2017 - by Dr Rachel Brown

A genome editing technique called 'base editing' has been used to correct the mutation causing the inherited blood disorder beta-thalassemia in human embryos... [Read More]

Video review: TED - Editing Our Evolution

02 October 2017 - by Eleanor Taylor

The latest CRISPR offering in the TED world comes from Dr Helen O'Neill, a molecular geneticist at University College London, UK. Her talk aimed to 'explore how and why the world and its inhabitants are constantly changing'... [Read More]

First genome editing of human embryos by UK scientists

25 September 2017 - by Paul Waldron

UK scientists have successfully edited the genome of human embryos to study the role of a gene key to the earliest stages of development... [Read More]

Podcast Review: The Life Scientific - Jennifer Doudna

25 September 2017 - by Rikita Patel

The new era of gene technology presents an exciting approach to treat deleterious, inherited genetic conditions. Presenter Jim Al-Khalili talks to Professor Jennifer Doudna, from her early life to her research into molecular biology, to the development of the CRISPR/Cas9 genome editing system... [Read More]

Cancer mutations explored using organoids and CRISPR

18 September 2017 - by Dr Molly Godfrey

Organoids and CRISPR/Cas9 have been combined in a novel method to study genetic mutations occurring in cancer... [Read More]

Doubt over human embryo editing study

04 September 2017 - by Annabel Slater

A group of scientists have challenged the landmark study which reported the first successful editing of human embryos for a genetic disease... [Read More]

Book Review: A Crack in Creation - Gene Editing and the Unthinkable Power to Control Evolution

21 August 2017 - by Annabel Slater

I'm glad to see a scientist engaging so strongly in public debate about the use of technology, rather than speculating on the sidelines... [Read More]

Dozens of new gene targets for cancer immunotherapy found

14 August 2017 - by Ebtehal Moussa

Over a 100 new genes that may be essential for cancer immunotherapy to work have been identified using a new CRISPR-based screen... [Read More]

Pig organ transplants a step closer as CRISPR removes viruses

14 August 2017 - by Cara Foley

Ancient viral genes have been eliminated from pigs using the genome editing tool CRISPR, according to research... [Read More]

RNA editing with CRISPR could treat genetic diseases

14 August 2017 - by Emma Lamb and Annabel Slater

Scientists have repurposed CRISPR to target the repetitive RNA sequences responsible for several genetic diseases... [Read More]

International genetics groups advocate germline CRISPR research

07 August 2017 - by Dr Greg Ball

Research into human germline genome editing should continue, recommends an international group of 11 human genetics organisations... [Read More]

NgAgo is a no-go

07 August 2017 - by Rachel Siden

The original paper promoting a new genome editing technology known as Natronobacterium gregoryi Argonaute (NgAgo) has been retracted... [Read More]

CRISPR patent dispute ramps up with filing of court appeal

31 July 2017 - by Dr Rachel Brown

The University of California has moved to appeal a decision of the US Patent Trial and Appeal Board over the use of CRISPR in eukaryotic cells... [Read More]

Book Review: The Gene Machine - How Genetic Technologies Are Changing the Way We Have Kids

24 July 2017 - by Cathal Farrell

'The Gene Machine' is award-winning author Bonnie Rochman's book on pre-and post-natal genetic testing. In it she navigates through classical bioethical issues... [Read More]

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Published by the Progress Educational Trust

CROSSING FRONTIERS

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Andy Greenfield

Dr Anna Smajdor

Dr Henry Malter

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross

Sandy Starr


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