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Preimplantation Genetic Diagnosis: The Who, the What, the Why and the How

Glossary

CRISPR/Cas9

A genome-editing platform that uses an enzyme (Cas9) to make a double-stranded break at a specific location in the genome, directed by a guide RNA.



Articles using this Glossary Item

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Cancer mutations explored using organoids and CRISPR

18 September 2017 - by Dr Molly Godfrey

Organoids and CRISPR/Cas9 have been combined in a novel method to study genetic mutations occurring in cancer... [Read More]

Doubt over human embryo editing study

04 September 2017 - by Annabel Slater

A group of scientists have challenged the landmark study which reported the first successful editing of human embryos for a genetic disease... [Read More]

Book Review: A Crack in Creation - Gene Editing and the Unthinkable Power to Control Evolution

21 August 2017 - by Annabel Slater

I'm glad to see a scientist engaging so strongly in public debate about the use of technology, rather than speculating on the sidelines... [Read More]

Dozens of new gene targets for cancer immunotherapy found

14 August 2017 - by Ebtehal Moussa

Over a 100 new genes that may be essential for cancer immunotherapy to work have been identified using a new CRISPR-based screen... [Read More]

Pig organ transplants a step closer as CRISPR removes viruses

14 August 2017 - by Cara Foley

Ancient viral genes have been eliminated from pigs using the genome editing tool CRISPR, according to research... [Read More]

RNA editing with CRISPR could treat genetic diseases

14 August 2017 - by Emma Lamb and Annabel Slater

Scientists have repurposed CRISPR to target the repetitive RNA sequences responsible for several genetic diseases... [Read More]

International genetics groups advocate germline CRISPR research

07 August 2017 - by Dr Greg Ball

Research into human germline genome editing should continue, recommends an international group of 11 human genetics organisations... [Read More]

NgAgo is a no-go

07 August 2017 - by Rachel Siden

The original paper promoting a new genome editing technology known as Natronobacterium gregoryi Argonaute (NgAgo) has been retracted... [Read More]

CRISPR patent dispute ramps up with filing of court appeal

31 July 2017 - by Dr Rachel Brown

The University of California has moved to appeal a decision of the US Patent Trial and Appeal Board over the use of CRISPR in eukaryotic cells... [Read More]

Book Review: The Gene Machine - How Genetic Technologies Are Changing the Way We Have Kids

24 July 2017 - by Cathal Farrell

'The Gene Machine' is award-winning author Bonnie Rochman's book on pre-and post-natal genetic testing. In it she navigates through classical bioethical issues... [Read More]

CRISPR used to record a film in bacteria

17 July 2017 - by Lea Goetz

Scientists have used the CRISPR/Cas system to encode a film in the genomes of living bacteria... [Read More]

Key CRISPR players agree to patent pool

17 July 2017 - by Kulraj Singh Bhangra

The Broad Institute of Massachusetts Institute of Technology and Harvard will take part in an initiative to simplify licensing CRISPR genome editing technology to other organisations and institutions... [Read More]

How new 'molecular scissors' may give crisper CRISPR

10 July 2017 - by Rikita Patel

Researchers have revealed the structure and action of a new type of 'molecular scissors' known as Cpf1, which may improve CRISPR genome editing.

China sides with Berkeley on CRISPR patent

03 July 2017 - by Rachel Siden

China's State Intellectual Property Office has granted the University of California a patent on CRISPR-Cas9 gene editing technology in the country.

Safety matters – can we be sure that CRISPR-Cas9 is not producing unwanted genetic alterations?

03 July 2017 - by Dr Dusko Ilic

Recent debate over the safety of CRISPR-Cas9 genome editing following a study that suggested it can cause hundreds of unexpected mutations left me puzzled... [Read More]

Huntington's disease in mice partly reversed using CRISPR

26 June 2017 - by Meghna Kataria

Eliminating the faulty protein that causes Huntingdon's disease goes some way to reversing disease progression in mice, a study has found... [Read More]

Biotech companies criticise CRISPR mutation study

19 June 2017 - by Charlotte Spicer

Two major biotech companies have criticised a recent study that claimed CRISPR may cause hundreds of unwanted mutations... [Read More]

Video Review: What is genome editing and how does it work?

19 June 2017 - by Kess Rowe

Genome editing is currently a hot topic. This is partly because of its promise in potentially treating genetic diseases and improving farmed crops; but also because it raises many ethical debates regarding safety and moral responses to this advancement... [Read More]

CRISPR genome editing may cause unintended mutations

05 June 2017 - by Charlotte Spicer

CRISPR may introduce hundreds of unwanted mutations into the genome, a small study finds... [Read More]

If you could alter the characteristics of future generations, would you do it?

22 May 2017 - by Dr Peter Mills

The Nuffield Council on Bioethics is seeking views on the reproductive uses of genome editing in humans. Regular readers of BioNews will know that genome editing (including with the CRISPR-Cas9 technique) offers a way of making precisely targeted modifications to DNA in living cells, harnessing the cells’ inbuilt repair mechanisms to repair a deliberate, double-stranded DNA break in a way that may either disable or introduce a functional DNA sequence... [Read More]

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