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Glossary

CRISPR

Clustered regularly-interspaced short palindromic repeats. (in bacteria) segments of DNA used for defence against pathogens; (in genome editing) refers to the CRISPR/Cas system used to edit DNA at specific locations in the genome.



Articles using this Glossary Item

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Real-time film shows CRISPR in action

20 November 2017 - by Helen Robertson

For the first time ever, researchers have been able to film, in real-time, the activity of the CRISPR technique on a strand of DNA... [Read More]

Broad Institute responds to Berkeley CRISPR patent appeal

30 October 2017 - by Jennifer Willows

The Broad Institute has filed arguments ahead of the upcoming CRISPR patent appeal hearing... [Read More]

'CRISPR-Gold' repairs muscular dystrophy gene in mouse model

09 October 2017 - by Emma Laycock

Scientists have repaired the faulty gene in a mouse model of muscular dystrophy by using gold nanoparticles to deliver the genome editing tool CRISPR-Cas9... [Read More]

CRISPR used to uncover new drug targets for cancer

02 October 2017 - by Rachel Reeves

New potential drug targets have been identified for cancers associated with KRAS gene mutations, which are thought to drive around 20-30 percent of all human cancers... [Read More]

How should we discuss genome editing in public?

02 October 2017 - by Sandy Starr

What do patients and laypeople think and know about genome editing and its implications? What are the best ways for experts and others to discuss genome editing in public, so as to improve public understanding and avoid confusion? The Progress Educational Trust has set out to answer these questions, with its 'Basic Understanding of Genome Editing' project.... [Read More]

Video review: TED - Editing Our Evolution

02 October 2017 - by Eleanor Taylor

The latest CRISPR offering in the TED world comes from Dr Helen O'Neill, a molecular geneticist at University College London, UK. Her talk aimed to 'explore how and why the world and its inhabitants are constantly changing'... [Read More]

Podcast Review: The Life Scientific - Jennifer Doudna

25 September 2017 - by Rikita Patel

The new era of gene technology presents an exciting approach to treat deleterious, inherited genetic conditions. Presenter Jim Al-Khalili talks to Professor Jennifer Doudna, from her early life to her research into molecular biology, to the development of the CRISPR/Cas9 genome editing system... [Read More]

Podcast Review: Editing the Embryo - removing harmful gene mutations

04 September 2017 - by Eleanor Taylor

As a scientist working in a fertility clinic, my normal everyday work routine is occasionally punctuated by the ripple effect that occurs when reports of a new groundbreaking reproductive technology enters the public consciousness. I am soon inundated with questions... [Read More]

Book Review: A Crack in Creation - Gene Editing and the Unthinkable Power to Control Evolution

21 August 2017 - by Annabel Slater

I'm glad to see a scientist engaging so strongly in public debate about the use of technology, rather than speculating on the sidelines... [Read More]

We need to talk about... CRISPR

21 August 2017 - by Giulia Cavaliere

Picture this - it's the last day in the office before the summer holidays, you're looking forward to some sunshine and warmth, email auto-response set, and all ready to go. Then, all of a sudden: the news... [Read More]

Dozens of new gene targets for cancer immunotherapy found

14 August 2017 - by Ebtehal Moussa

Over a 100 new genes that may be essential for cancer immunotherapy to work have been identified using a new CRISPR-based screen... [Read More]

EPO awards CRISPR patent to European biotech

14 August 2017 - by Ryan Ross

German-based company MilliporeSigma has announced that the European Patent Office intends to approve its CRISPR patent for use in eukaryotic cells... [Read More]

RNA editing with CRISPR could treat genetic diseases

14 August 2017 - by Emma Lamb and Annabel Slater

Scientists have repurposed CRISPR to target the repetitive RNA sequences responsible for several genetic diseases... [Read More]

Disease-causing mutation edited out of human embryos

07 August 2017 - by Charlotte Spicer

Scientists have published their study confirming they are the first to correct a disease-causing mutation in human embryos using genome editing... [Read More]

Gene therapy skin grafts for obesity and diabetes

07 August 2017 - by Annabel Slater

A proof-of-concept study in mice has demonstrated how skin grafts could deliver gene therapy for obesity and diabetes... [Read More]

CRISPR patent dispute ramps up with filing of court appeal

31 July 2017 - by Dr Rachel Brown

The University of California has moved to appeal a decision of the US Patent Trial and Appeal Board over the use of CRISPR in eukaryotic cells... [Read More]

Radio Review: The Inquiry - Is Gene Editing Out of Control?

31 July 2017 - by Cara Foley

The broadcast by BBC World Service is split into four parts, each with an assigned 'expert witness'. The first chapter tackles 'The Language of Life', aiming to elucidate exactly what DNA, genes and genome editing are... [Read More]

US lab may have edited human embryos for first time

31 July 2017 - by Charlotte Spicer

Scientists in the US may have successfully used genome editing in human embryos to correct disease mutations, according to a report by MIT Technology Review... [Read More]

Event Review: Wellcome Collection Packed Lunch - DNA Repair

17 July 2017 - by Charlotte Spicer

It’s not often a PhD student finds themselves with a whole hour to break for lunch. So when asked to review one of the Wellcome Trust’s 'Packed Lunch' talks, I jumped at the chance to make better use of some rare free time. The monthly event, situated at the Euston-based Wellcome Collection, promises to feed your curiosity... [Read More]

Key CRISPR players agree to patent pool

17 July 2017 - by Kulraj Singh Bhangra

The Broad Institute of Massachusetts Institute of Technology and Harvard will take part in an initiative to simplify licensing CRISPR genome editing technology to other organisations and institutions... [Read More]

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Events using this Glossary Item

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Published by the Progress Educational Trust

CROSSING FRONTIERS

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Andy Greenfield

Dr Anna Smajdor

Dr Henry Malter

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross

Sandy Starr


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