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Preimplantation Genetic Diagnosis: The Who, the What, the Why and the How

Glossary

CRISPR

Clustered regularly-interspaced short palindromic repeats. (in bacteria) segments of DNA used for defence against pathogens; (in genome editing) refers to the CRISPR/Cas system used to edit DNA at specific locations in the genome.



Articles using this Glossary Item

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CRISPR genome editing may cause unintended mutations

05 June 2017 - by Charlotte Spicer

CRISPR may introduce hundreds of unwanted mutations into the genome, a small study finds... [Read More]

CRISPR gene-editing eliminates HIV in mice

08 May 2017 - by Emma Laycock

US scientists have used CRISPR gene-editing to remove HIV DNA from the genomes of living animals, eliminating further infection.

The CRISPR patent dispute - Europe and the US

02 May 2017 - by Brian Nolan

The European Patent Office and the United States Patent and Trademark Office have been thrust into a dispute pitting the University of California, Berkeley and the University of Vienna against the Broad Institute of MIT and Harvard University. Scientists and inventors have been watching the decisions of the EPO and USPTO because these decisions may leave one of these entities with a patent portfolio worth billions of dollars... [Read More]

UK Parliamentary committee publishes report on genomics and genome editing

02 May 2017 - by Sandy Starr

The Science and Technology Committee of the UK Parliament's House of Commons has published a brief report of its wide-ranging inquiry into genomics and genome editing... [Read More]

Highly sensitive CRISPR diagnostic tool created

24 April 2017 - by Jennifer Willows and Annabel Slater

A new highly sensitive diagnostic system for diseases has been adapted from CRISPR... [Read More]

The media, synthetic biology and CRISPR - fears vs. reality

10 April 2017 - by Sean Byrne

A recent Wall Street Journal article, 'DIY Gene Editing: Fast, Cheap — and Worrisome', describes the Saturday afternoon of teenager, Kian Sadeghi, as he learns to use CRISPR/Cas9 at the Genspace Community Lab in Brooklyn, New York. Like many news articles, the main angle of the article is that new science and technology present a problem... [Read More]

University of California win CRISPR patent battle in Europe

03 April 2017 - by Jennifer Willows

The European Patent Office has declared that it intends to grant a broad patent for the use of CRISPR technologies to the University of California, the University of Vienna and Dr Emmanuelle Charpentier of the Max-Planck Institute in Berlin... [Read More]

Podcast Review: CRISPR Updated

27 March 2017 - by Emma Laycock

Radiolab explores the science, the uses and the ethics of CRISPR in this podcast that was two years in the making... [Read More]

First genome editing of normal human embryos

13 March 2017 - by Dr Katie Howe

Chinese scientists have successfully used genome editing to correct mutations in viable human embryos for the first time... [Read More]

The craftsmanship of mimicking embryogenesis in a dish

13 March 2017 - by Dr Dusko Ilic

The regulatory mechanisms governing organ development are, in general, poorly defined. To recreate the complex processes involved in organ growth and maturation, scientists have started fiddling with three-dimensional (3D) cell culture... [Read More]

Genome editing: CRISPR at the cutting edge

23 January 2017 - by Annabel Slater

The fourth session of the Progress Educational Trust's annual conference 'Rethinking the Ethics of Embryo Research: Genome Editing, 14 Days and Beyond' delved into the new genome-editing technique CRISPR/Cas9 and what it means for embryo research... [Read More]

Anti-CRISPR - an off-switch for genome editing

09 January 2017 - by Dr Özge Özkaya

Scientists have discovered a new set of proteins that can block the CRISPR/Cas9 system... [Read More]

Families with genetic diseases support genome-editing research

28 November 2016 - by Lucas Taylor

More than 75 percent of those with a genetic condition, and their family members, support the use of genome-editing technology, a survey has found... [Read More]

China begins first CRISPR human therapy trial

21 November 2016 - by 

Chinese scientists have injected CRISPR/Cas9 gene-edited cells into a human for the first time... [Read More]

Therapeutic editing of the human genome – Jewish bioethical perspectives

14 November 2016 - by Dr Avi Lerner

Jewish bioethics may help to broaden the discussion of the ethical concerns that emerge from editing the human genome... [Read More]

Book Review: Redesigning Life – How Genome Editing will Transform the World

07 November 2016 - by Annabel Slater

Dr John Parrington thinks the ethics of genome editing should be shaped by scientifically informed public debate, and he hopes his book will provide a starting point... [Read More]

Event Review: 'Genome editing: an ethical review' launch

31 October 2016 - by Jennifer Willows

The Nuffield Council on Bioethics presented its preliminary report 'Genome editing: an ethical review' in the genteel surroundings of the Royal Geographical Society in South Kensington... [Read More]

Genome editing using nanoparticle technology treats blood disorder

31 October 2016 - by Sarah Gregory

Researchers have developed a novel genome-editing technology to correct the defective gene that causes the blood disorder beta-thalassemia... [Read More]

The Mexican mitochondrial case and moral supremacy

10 October 2016 - by Giulia Cavaliere

The announcement of the first baby born using mitochondrial spindle transfer, one of the two techniques that allow the replacement of faulty mitochondrial DNA, caught the UK scientific and bioethics community by surprise... [Read More]

CRISPR used to investigate non-coding regions of the genome

03 October 2016 - by Helen Robertson

Two teams of researchers have used CRISPR genome editing technology to identify 'non-coding' regions of the genome for the first time... [Read More]

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