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Preimplantation Genetic Diagnosis: The Who, the What, the Why and the How

Glossary

Genome editing

To insert, delete, replace, or alter the expression, of DNA at targeted locations in the genome. Examples include zinc finger nucleases (ZFNs), TALEN and CRISPR/Cas.



Articles using this Glossary Item

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Cancer mutations explored using organoids and CRISPR

18 September 2017 - by Dr Molly Godfrey

Organoids and CRISPR/Cas9 have been combined in a novel method to study genetic mutations occurring in cancer... [Read More]

Doubt over human embryo editing study

04 September 2017 - by Annabel Slater

A group of scientists have challenged the landmark study which reported the first successful editing of human embryos for a genetic disease... [Read More]

Podcast Review: Editing the Embryo - removing harmful gene mutations

04 September 2017 - by Eleanor Taylor

As a scientist working in a fertility clinic, my normal everyday work routine is occasionally punctuated by the ripple effect that occurs when reports of a new groundbreaking reproductive technology enters the public consciousness. I am soon inundated with questions... [Read More]

Americans becoming open to human genome editing

21 August 2017 - by Dr Rachel Huddart

A new survey suggests that Americans are becoming more accepting of the use of genome editing in humans, and there is strong support for more public involvement in discussions on the technology... [Read More]

Book Review: A Crack in Creation - Gene Editing and the Unthinkable Power to Control Evolution

21 August 2017 - by Annabel Slater

I'm glad to see a scientist engaging so strongly in public debate about the use of technology, rather than speculating on the sidelines... [Read More]

We need to talk about…CRISPR

21 August 2017 - by Giulia Cavaliere

Picture this - it's the last day in the office before the summer holidays, you're looking forward to some sunshine and warmth, email auto-response set, and all ready to go. Then, all of a sudden: the news... [Read More]

Pig organ transplants a step closer as CRISPR removes viruses

14 August 2017 - by Cara Foley

Ancient viral genes have been eliminated from pigs using the genome editing tool CRISPR, according to research... [Read More]

RNA editing with CRISPR could treat genetic diseases

14 August 2017 - by Emma Lamb and Annabel Slater

Scientists have repurposed CRISPR to target the repetitive RNA sequences responsible for several genetic diseases... [Read More]

Disease-causing mutation edited out of human embryos

07 August 2017 - by Charlotte Spicer

Scientists have published their study confirming they are the first to correct a disease-causing mutation in human embryos using genome editing... [Read More]

Gene therapy skin grafts for obesity and diabetes

07 August 2017 - by Annabel Slater

A proof-of-concept study in mice has demonstrated how skin grafts could deliver gene therapy for obesity and diabetes... [Read More]

International genetics groups advocate germline CRISPR research

07 August 2017 - by Dr Greg Ball

Research into human germline genome editing should continue, recommends an international group of 11 human genetics organisations... [Read More]

NgAgo is a no-go

07 August 2017 - by Rachel Siden

The original paper promoting a new genome editing technology known as Natronobacterium gregoryi Argonaute (NgAgo) has been retracted... [Read More]

CRISPR patent dispute ramps up with filing of court appeal

31 July 2017 - by Dr Rachel Brown

The University of California has moved to appeal a decision of the US Patent Trial and Appeal Board over the use of CRISPR in eukaryotic cells... [Read More]

Radio Review: The Inquiry - Is Gene Editing Out of Control?

31 July 2017 - by Cara Foley

The broadcast by BBC World Service is split into four parts, each with an assigned 'expert witness'. The first chapter tackles 'The Language of Life', aiming to elucidate exactly what DNA, genes and genome editing are... [Read More]

US lab may have edited human embryos for first time

31 July 2017 - by Charlotte Spicer

Scientists in the US may have successfully used genome editing in human embryos to correct disease mutations, according to a report by MIT Technology Review... [Read More]

Key CRISPR players agree to patent pool

17 July 2017 - by Kulraj Singh Bhangra

The Broad Institute of Massachusetts Institute of Technology and Harvard will take part in an initiative to simplify licensing CRISPR genome editing technology to other organisations and institutions... [Read More]

How new 'molecular scissors' may give crisper CRISPR

10 July 2017 - by Rikita Patel

Researchers have revealed the structure and action of a new type of 'molecular scissors' known as Cpf1, which may improve CRISPR genome editing.

China sides with Berkeley on CRISPR patent

03 July 2017 - by Rachel Siden

China's State Intellectual Property Office has granted the University of California a patent on CRISPR-Cas9 gene editing technology in the country.

Event Review: Jennifer Doudna talks to Adam Rutherford

03 July 2017 - by Annabel Slater

'This technology really gets the imagination going. It's almost anything that you could imagine wanting to control at the level of genetics, is now in principle within reach.' And the power to control evolution raises important questions of responsibility. This is the message of Professor Jennifer Doudna... [Read More]

Safety matters – can we be sure that CRISPR-Cas9 is not producing unwanted genetic alterations?

03 July 2017 - by Dr Dusko Ilic

Recent debate over the safety of CRISPR-Cas9 genome editing following a study that suggested it can cause hundreds of unexpected mutations left me puzzled... [Read More]

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Events using this Glossary Item

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