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Human Clinical Embryology and Assisted Conception MSc

Glossary

Genome editing

To insert, delete, replace, or alter the expression, of DNA at targeted locations in the genome. Examples include zinc finger nucleases (ZFNs), TALEN and CRISPR/Cas.



Articles using this Glossary Item

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If you could alter the characteristics of future generations, would you do it?

22 May 2017 - by Dr Peter Mills

The Nuffield Council on Bioethics is seeking views on the reproductive uses of genome editing in humans. Regular readers of BioNews will know that genome editing (including with the CRISPR-Cas9 technique) offers a way of making precisely targeted modifications to DNA in living cells, harnessing the cells’ inbuilt repair mechanisms to repair a deliberate, double-stranded DNA break in a way that may either disable or introduce a functional DNA sequence... [Read More]

Plan to build synthetic human DNA genome gains momentum

08 May 2017 - by Annabel Slater

Human DNA could be artificially synthesised in around five years or less, according to one of the organisers behind the Genome Project-write plan... [Read More]

The CRISPR patent dispute - Europe and the US

02 May 2017 - by Brian Nolan

The European Patent Office and the United States Patent and Trademark Office have been thrust into a dispute pitting the University of California, Berkeley and the University of Vienna against the Broad Institute of MIT and Harvard University. Scientists and inventors have been watching the decisions of the EPO and USPTO because these decisions may leave one of these entities with a patent portfolio worth billions of dollars... [Read More]

UK Parliamentary committee publishes report on genomics and genome editing

02 May 2017 - by Sandy Starr

The Science and Technology Committee of the UK Parliament's House of Commons has published a brief report of its wide-ranging inquiry into genomics and genome editing... [Read More]

Podcast Review: CRISPR Updated

27 March 2017 - by Emma Laycock

Radiolab explores the science, the uses and the ethics of CRISPR in this podcast that was two years in the making... [Read More]

First genome editing of normal human embryos

13 March 2017 - by Dr Katie Howe

Chinese scientists have successfully used genome editing to correct mutations in viable human embryos for the first time... [Read More]

The craftsmanship of mimicking embryogenesis in a dish

13 March 2017 - by Dr Dusko Ilic

The regulatory mechanisms governing organ development are, in general, poorly defined. To recreate the complex processes involved in organ growth and maturation, scientists have started fiddling with three-dimensional (3D) cell culture... [Read More]

Broad Institute CRISPR patents upheld

20 February 2017 - by Ryan Ross

The US Patent and Trademark Office has upheld the right of the Broad Institute of MIT and Harvard to the genome-editing tool CRISPR/Cas9... [Read More]

Major US report supports human genome editing

20 February 2017 - by Dr Rachel Huddart

An influential advisory group has given cautious support to the idea of making heritable changes to the human genome in order to treat or prevent disease... [Read More]

ACMG recommends caution on genome editing

06 February 2017 - by Rachel Siden

The American College of Medical Genetics and Genomics has published a statement recommending caution over the clinical application of genome editing... [Read More]

Doudna and Charpentier win 2017 Japan Prize for CRISPR

06 February 2017 - by Dr Linda Wijlaars

Professors Jennifer Doudna and Emmanuelle Charpentier have won the 2017 Japan Prize for their work on the genome-editing technology CRISPR/Cas9.... [Read More]

What's so special about the status of the embryo?

30 January 2017 - by Dr Jess Buxton

The fifth and final session of the Progress Educational Trust's annual conference 'Rethinking the Ethics of Embryo Research: Genome Editing, 14 Days and Beyond' covered a range of perspectives on the status of the human embryo... [Read More]

Genome editing successfully treats leukaemia

25 January 2017 - by Dr Loredana Guglielmi

Doctors at London's Great Ormond Street Hospital have used genome editing to successfully treat two children with leukaemia... [Read More]

Genome editing: CRISPR at the cutting edge

23 January 2017 - by Annabel Slater

The fourth session of the Progress Educational Trust's annual conference 'Rethinking the Ethics of Embryo Research: Genome Editing, 14 Days and Beyond' delved into the new genome-editing technique CRISPR/Cas9 and what it means for embryo research... [Read More]

Podcast Review: The Naked Scientists - All human life is here

23 January 2017 - by Rachel Siden

In this podcast, Professor Magdalena Zernicka-Goetz and Sarah Norcross discuss the current UK ban on researching human embryos in the lab for longer than 14 days... [Read More]

Discussion of ethics of new IVG technique is needed, say US experts

16 January 2017 - by Annabel Slater

Three US experts say public conversation should begin now on the ethical challenges raised by a new fertility technology that could reprogram any human cell into eggs and sperm... [Read More]

Anti-CRISPR - an off-switch for genome editing

09 January 2017 - by Dr Özge Özkaya

Scientists have discovered a new set of proteins that can block the CRISPR/Cas9 system... [Read More]

Hearings begin in CRISPR US patent dispute

12 December 2016 - by Antony Blackburn-Starza

Oral arguments from lawyers acting for the Broad Institute and the University of California, Berkeley, in the high-profile CRISPR/Cas9 patent dispute have been heard in Virginia... [Read More]

Families with genetic diseases support genome-editing research

28 November 2016 - by Lucas Taylor

More than 75 percent of those with a genetic condition, and their family members, support the use of genome-editing technology, a survey has found... [Read More]

China begins first CRISPR human therapy trial

21 November 2016 - by 

Chinese scientists have injected CRISPR/Cas9 gene-edited cells into a human for the first time... [Read More]

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