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Glossary

Genome editing

To insert, delete, replace, or alter the expression, of DNA at targeted locations in the genome. Examples include zinc finger nucleases (ZFNs), TALEN and CRISPR/Cas.



Articles using this Glossary Item

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Key CRISPR players agree to patent pool

17 July 2017 - by Kulraj Singh Bhangra

The Broad Institute of Massachusetts Institute of Technology and Harvard will take part in an initiative to simplify licensing CRISPR genome editing technology to other organisations and institutions... [Read More]

How new 'molecular scissors' may give crisper CRISPR

10 July 2017 - by Rikita Patel

Researchers have revealed the structure and action of a new type of 'molecular scissors' known as Cpf1, which may improve CRISPR genome editing.

China sides with Berkeley on CRISPR patent

03 July 2017 - by Rachel Siden

China's State Intellectual Property Office has granted the University of California a patent on CRISPR-Cas9 gene editing technology in the country.

Event Review: Jennifer Doudna talks to Adam Rutherford

03 July 2017 - by Annabel Slater

'This technology really gets the imagination going. It's almost anything that you could imagine wanting to control at the level of genetics, is now in principle within reach.' And the power to control evolution raises important questions of responsibility. This is the message of Professor Jennifer Doudna... [Read More]

Safety matters – can we be sure that CRISPR-Cas9 is not producing unwanted genetic alterations?

03 July 2017 - by Dr Dusko Ilic

Recent debate over the safety of CRISPR-Cas9 genome editing following a study that suggested it can cause hundreds of unexpected mutations left me puzzled... [Read More]

Event Review: Fathers, Donors and Men - Mother-Child Communication in Solo Mother Families

26 June 2017 - by Dr Kylie Baldwin

New technologies, procedures, and developments in reproductive science such as egg freezing, mitochondrial donation and genome editing have occupied many column inches, as well as much public and academic discussion in recent years. However, the topic of gamete donation remains an area of interest and continued site of controversy... [Read More]

Huntington's disease in mice partly reversed using CRISPR

26 June 2017 - by Meghna Kataria

Eliminating the faulty protein that causes Huntingdon's disease goes some way to reversing disease progression in mice, a study has found... [Read More]

Biotech companies criticise CRISPR mutation study

19 June 2017 - by Charlotte Spicer

Two major biotech companies have criticised a recent study that claimed CRISPR may cause hundreds of unwanted mutations... [Read More]

Video Review: What is genome editing and how does it work?

19 June 2017 - by Kess Rowe

Genome editing is currently a hot topic. This is partly because of its promise in potentially treating genetic diseases and improving farmed crops; but also because it raises many ethical debates regarding safety and moral responses to this advancement... [Read More]

CRISPR genome editing may cause unintended mutations

05 June 2017 - by Charlotte Spicer

CRISPR may introduce hundreds of unwanted mutations into the genome, a small study finds... [Read More]

Genome editing used to slow cancer growth

30 May 2017 - by Annabel Slater

US scientists have delayed cancer cell growth by using genome editing to remove a protein... [Read More]

If you could alter the characteristics of future generations, would you do it?

22 May 2017 - by Dr Peter Mills

The Nuffield Council on Bioethics is seeking views on the reproductive uses of genome editing in humans. Regular readers of BioNews will know that genome editing (including with the CRISPR-Cas9 technique) offers a way of making precisely targeted modifications to DNA in living cells, harnessing the cells’ inbuilt repair mechanisms to repair a deliberate, double-stranded DNA break in a way that may either disable or introduce a functional DNA sequence... [Read More]

Plan to build synthetic human DNA genome gains momentum

08 May 2017 - by Annabel Slater

Human DNA could be artificially synthesised in around five years or less, according to one of the organisers behind the Genome Project-write plan... [Read More]

The CRISPR patent dispute - Europe and the US

02 May 2017 - by Brian Nolan

The European Patent Office and the United States Patent and Trademark Office have been thrust into a dispute pitting the University of California, Berkeley and the University of Vienna against the Broad Institute of MIT and Harvard University. Scientists and inventors have been watching the decisions of the EPO and USPTO because these decisions may leave one of these entities with a patent portfolio worth billions of dollars... [Read More]

UK Parliamentary committee publishes report on genomics and genome editing

02 May 2017 - by Sandy Starr

The Science and Technology Committee of the UK Parliament's House of Commons has published a brief report of its wide-ranging inquiry into genomics and genome editing... [Read More]

Podcast Review: CRISPR Updated

27 March 2017 - by Emma Laycock

Radiolab explores the science, the uses and the ethics of CRISPR in this podcast that was two years in the making... [Read More]

First genome editing of normal human embryos

13 March 2017 - by Dr Katie Howe

Chinese scientists have successfully used genome editing to correct mutations in viable human embryos for the first time... [Read More]

The craftsmanship of mimicking embryogenesis in a dish

13 March 2017 - by Dr Dusko Ilic

The regulatory mechanisms governing organ development are, in general, poorly defined. To recreate the complex processes involved in organ growth and maturation, scientists have started fiddling with three-dimensional (3D) cell culture... [Read More]

Broad Institute CRISPR patents upheld

20 February 2017 - by Ryan Ross

The US Patent and Trademark Office has upheld the right of the Broad Institute of MIT and Harvard to the genome-editing tool CRISPR/Cas9... [Read More]

Major US report supports human genome editing

20 February 2017 - by Dr Rachel Huddart

An influential advisory group has given cautious support to the idea of making heritable changes to the human genome in order to treat or prevent disease... [Read More]

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