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Glossary

Genome editing

To insert, delete, replace, or alter the expression, of DNA at targeted locations in the genome. Examples include zinc finger nucleases (ZFNs), TALEN and CRISPR/Cas.



Articles using this Glossary Item

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Real-time film shows CRISPR in action

20 November 2017 - by Helen Robertson

For the first time ever, researchers have been able to film, in real-time, the activity of the CRISPR technique on a strand of DNA... [Read More]

Canadian scientists call for end to criminal ban on germline genome-editing

13 November 2017 - by Rachel Siden

Members of Canada's Stem Cell Network have called for the country to re-examine its laws banning genome editing research on the human germline... [Read More]

Why germline genome editing may be discriminatory

13 November 2017 - by Dr Calum MacKellar

On the 20th anniversary of the of the 1997 European Convention on Human Rights and Biomedicine (Oviedo Convention), the Council of Europe Committee on Bioethics organised an international conference entitled ‘Relevance and Challenges’ last month in Strasbourg, France... [Read More]

Broad Institute responds to Berkeley CRISPR patent appeal

30 October 2017 - by Jennifer Willows

The Broad Institute has filed arguments ahead of the upcoming CRISPR patent appeal hearing... [Read More]

Event Review: Manchester Science Festival - Reproduction 2.0

30 October 2017 - by Laura O'Donovan

Almost forty years have passed since the 1978 birth of Louise Brown – the first IVF baby – launched a revolution in reproductive medicine resulting in over 250,000 births in the UK alone... [Read More]

New advance in DNA base editing tools

30 October 2017 - by Julianna Photopoulos

Scientists have developed the genome editing technique known as 'base editing' to turn adenine-thymine base pairs back to guanine-cytosine... [Read More]

RNA editing tools could create new disease therapies

30 October 2017 - by Dr Rachel Huddart

A new molecular tool to change individual letters in an RNA sequence may open up new possibilities for gene therapy... [Read More]

'CRISPR-Gold' repairs muscular dystrophy gene in mouse model

09 October 2017 - by Emma Laycock

Scientists have repaired the faulty gene in a mouse model of muscular dystrophy by using gold nanoparticles to deliver the genome editing tool CRISPR-Cas9... [Read More]

Podcast Review: Naked Genetics - Exposing the Contents of Your Genes

09 October 2017 - by Cara Foley

'Would you donate your genome?' Straight to the point, the introduction immediately grabbed my attention. Genome donation wasn't something I had even considered before listening to this podcast, so I was very curious to learn more... [Read More]

CRISPR used to uncover new drug targets for cancer

02 October 2017 - by Rachel Reeves

New potential drug targets have been identified for cancers associated with KRAS gene mutations, which are thought to drive around 20-30 percent of all human cancers... [Read More]

Genome editing targets beta-thalassemia in human embryos

02 October 2017 - by Dr Rachel Brown

A genome editing technique called 'base editing' has been used to correct the mutation causing the inherited blood disorder beta-thalassemia in human embryos... [Read More]

How should we discuss genome editing in public?

02 October 2017 - by Sandy Starr

What do patients and laypeople think and know about genome editing and its implications? What are the best ways for experts and others to discuss genome editing in public, so as to improve public understanding and avoid confusion? The Progress Educational Trust has set out to answer these questions, with its 'Basic Understanding of Genome Editing' project.... [Read More]

Video review: TED - Editing Our Evolution

02 October 2017 - by Eleanor Taylor

The latest CRISPR offering in the TED world comes from Dr Helen O'Neill, a molecular geneticist at University College London, UK. Her talk aimed to 'explore how and why the world and its inhabitants are constantly changing'... [Read More]

First genome editing of human embryos by UK scientists

25 September 2017 - by Paul Waldron

UK scientists have successfully edited the genome of human embryos to study the role of a gene key to the earliest stages of development... [Read More]

Podcast Review: The Life Scientific - Jennifer Doudna

25 September 2017 - by Rikita Patel

The new era of gene technology presents an exciting approach to treat deleterious, inherited genetic conditions. Presenter Jim Al-Khalili talks to Professor Jennifer Doudna, from her early life to her research into molecular biology, to the development of the CRISPR/Cas9 genome editing system... [Read More]

Cancer mutations explored using organoids and CRISPR

18 September 2017 - by Dr Molly Godfrey

Organoids and CRISPR/Cas9 have been combined in a novel method to study genetic mutations occurring in cancer... [Read More]

Doubt over human embryo editing study

04 September 2017 - by Annabel Slater

A group of scientists have challenged the landmark study which reported the first successful editing of human embryos for a genetic disease... [Read More]

Podcast Review: Editing the Embryo - removing harmful gene mutations

04 September 2017 - by Eleanor Taylor

As a scientist working in a fertility clinic, my normal everyday work routine is occasionally punctuated by the ripple effect that occurs when reports of a new groundbreaking reproductive technology enters the public consciousness. I am soon inundated with questions... [Read More]

Americans becoming open to human genome editing

21 August 2017 - by Dr Rachel Huddart

A new survey suggests that Americans are becoming more accepting of the use of genome editing in humans, and there is strong support for more public involvement in discussions on the technology... [Read More]

Book Review: A Crack in Creation - Gene Editing and the Unthinkable Power to Control Evolution

21 August 2017 - by Annabel Slater

I'm glad to see a scientist engaging so strongly in public debate about the use of technology, rather than speculating on the sidelines... [Read More]

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Events using this Glossary Item

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Published by the Progress Educational Trust

CROSSING FRONTIERS

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Andy Greenfield

Dr Anna Smajdor

Dr Henry Malter

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross

Sandy Starr


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