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Complex disease

Complex diseases are caused by a combination of multiple genetic, environmental, and lifestyle factors acting together.

Articles using this Glossary Item


Female is not 'default sex' of embryos

21 August 2017 - by Jamie Rickman

A protein that controls removal of male reproductive tissue in female mice embryos has been discovered... 

Genetic study identifies new type of muscular dystrophy

13 February 2017 - by Caroline Casey

Scientists have identified a unique form of congenital muscular dystrophy, characterised by short stature, intellectual disabilities and cataracts... [Read More]

Genetic basis of schizophrenia unfolds

24 October 2016 - by Isobel Steer

Scientists using a new 3D chromosome-mapping technique have uncovered a genetic connection between schizophrenia and early fetal brain development ... [Read More]

Gene therapy reverses inherited blindness

03 May 2016 - by Sarah Gregory

A trial of gene therapy for choroideremia, a rare form of inherited blindness, has partially restored the vision of several patients... [Read More]

NIH launches $280m genome-sequencing project

25 January 2016 - by Rikita Patel

The US National Institutes of Health (NIH) has pledged over US$280 million over the next four years to genome sequencing targeting common and rare human diseases... [Read More]

Genome trawl yields 11 new Alzheimer's risk genes

04 November 2013 - by Dr Rachel Brown

Eleven genetic variants linked to late-onset Alzheimer's disease have been found by the largest study on the genetics behind the condition to date... [Read More]

Scientists warn of potential mitochondrial replacement IVF health risks

23 September 2013 - by Dr Rosie Gilchrist

A group of scientists has expressed concerns that it may be too soon to bring mitochondrial replacement techniques, which are still under development, to the clinic.... [Read More]

Genetic test speeds up diagnosis for children with cataracts

16 September 2013 - by Siobhan Chan

A blood test for children born with cataracts will allow faster diagnosis and more personalised treatment, according to researchers at the British Society for Genetic Medicine's annual conference... [Read More]

Gene defect 'switched off' in human tissue

01 July 2013 - by Simon Hazelwood-Smith

Scientists have for the first time been able to switch on and off the effects of a genetic disease, myotonic dystrophy, in human muscle tissue... [Read More]

Multimillion-dollar grants for stem cell biobank

25 March 2013 - by Dr Shanya Sivakumaran

The California Institute for Regenerative Medicine in San Francisco, USA, has awarded two multimillion-dollar grants to Cellular Dynamics International in Wisconsin and Coriell Institute for Medical Research in New Jersey to generate and bank iPS cell lines.... [Read More]

Genetic regions that are major risk factors for osteoarthritis identified

09 July 2012 - by Helen Brooks

Scientists have identified eight regions of the genetic code associated with an increased risk of developing osteoarthritis... [Read More]

Report Review: Consumer Genetic Testing

02 April 2012 - by Ruth Saunders

Last week the Parliamentary Office of Science and Technology (POST) released a POST Note - a guide for MPs and other parliamentarians on science and technology issues - on consumer genetic testing... [Read More]

The myth of the genomic revolution

06 February 2012 - by Dr Stuart Hogarth and Professor Paul Martin

'Building on our inheritance: Genomic technology in healthcare' is the latest in a long line of reports that have sought to assess the potential of genomic medicine and to outline how policy can best support its development.... [Read More]

Gene link to oesophageal cancer

23 January 2012 - by Ayesha Jadoon

The gene causing a skin disorder which predisposes to oesophageal cancer has been identified. More than nine out of ten people with tylosis, which causes thickening of the skin on the palms and soles, will develop oesophageal cancer before the age of 65, but until now the reason for this was obscure... [Read More]

Mice live up to three times longer after progenitor cell injections

16 January 2012 - by Ruth Saunders

Stem cell injections have been found to slow down the effects of aging in mice. Researchers have developed a stem cell treatment that significantly slows down aging and increases life span in mice with progeria, a rare genetic disease causing advanced aging... [Read More]

Stress response spans generations

04 July 2011 - by Ruth Pidsley

Scientists have shown that the effects of stress can be passed from one generation to the next via chemical changes to the DNA which turn genes on or off without altering the code itself.... [Read More]

TV Review: The Gene Code - The Book of Life/Unlocking the Code

09 May 2011 - by Professor Sandy Raeburn

Nearly twenty years ago, a medical school I know well was deciding whether to incorporate the university genetics department. One senior medical professor cautioned that science-focused geneticists would be well advised to stop studying fruit flies, snails and other animal species in favour of 'real genetic research' into human genetics.... [Read More]

New genetic markers for heart disease discovered

14 March 2011 - by MacKenna Roberts

An international research consortium has discovered 13 new genetic markers and confirmed ten previously identified markers associated with heart disease. The study, one of the world's largest, more than doubles the known genetic risk factors for coronary artery disease, a common cause of heart attacks and strokes.... [Read More]

Gene, toxin and virus interact in Crohn's disease

05 July 2010 - by Victoria Kay

US scientists have shown for the first time how a virus, a toxin and a genetic mutation interact to cause Crohn's disease. The study, in mice, may help explain why many people with disease risk genes don't develop the condition... [Read More]

Cell's 'power cells' protect against stroke

10 May 2010 - by Dr Marianne Kennedy

Certain variations of mitochondrial DNA are protective against strokes, according to a recent study in The Lancet Neurology.... [Read More]


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