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King's College London - Health: More than a medical matter


Clinical trial

Research study carried out with patients, usually to test a new treatment or drug.

Articles using this Glossary Item

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Gene test can predict prostate cancer recurrence

14 April 2014 - by Simon Hazelwood-Smith

A genetic test has been developed to predict the likelihood of prostate cancer returning after treatment. The test looks for 'genetic signatures' often found in recurring cancers... [Read More]

BRCA1 cancer study suggests alternative to major surgery

31 March 2014 - by Dr Sarah Spain

BRCA1 mutations put carriers at high risk of cancer by failing to protect cells against the effects of high levels of oestrogen hormone found in breast and ovary tissue, researchers have established... [Read More]

Non-invasive DNA test picks up more colon cancers and more false positives

24 March 2014 - by Daryl Ramai

A stool-sample DNA test has detected 92 percent of colon cancers in a large clinical trial, compared to 74 percent picked up by the most commonly used non-invasive test... [Read More]

'Fat gene' carriers should forgo fried foods, study finds

24 March 2014 - by Anna Cauldwell

People with genes that predispose them to excess weight and obesity are more likely to put on weight from eating fried food, a study says... [Read More]

Gene therapy could be 'functional cure' for HIV

10 March 2014 - by Dr Lanay Tierney

A potential HIV therapy where patients have their blood cells genetically modified to help them resist the virus is safe and promising as a treatment, say researchers after a small clinical trial... [Read More]

T-cell gene therapy successful in early clinical trial

24 February 2014 - by Chris Hardy

Researchers trialling a gene therapy-based treatment for leukemia have said the early results go beyond anything they could have thought of in their 'wildest dreams'... [Read More]

Whole genome testing used to guide breast cancer treatment

10 February 2014 - by Barbara Czub

Whole genome testing has been used to guide tailored treatment against advanced breast cancer in a group of 43 patients. The scientists behind the study say their research is a step on the path towards 'personalised medicine' where individual genetic makeup informs treatment choice... [Read More]

Gene therapy promising in Parkinson's patients

10 January 2014 - by Kimberley Bryon-Dodd

Patients in a clinical trial to treat Parkinson's disease with a form of gene therapy have showed signs of significant improvements in their motor-function, according to a report published in the Lancet... [Read More]

Screening dilemmas: disability, disease or something in-between?

25 November 2013 - by Dr Felicity Boardman

I was struck by a recent article that pushed to free Down's syndrome from inappropriate, negative language - that of 'disease', of 'risk' and of 'defect'... [Read More]

Clinical-stage gene therapy company launched

11 November 2013 - by Dr Naqash Raja

The Children's Hospital of Philadelphia has invested US $50 million in a biotech start-up in an effort to commercialise gene therapy... [Read More]

Mitochondrial replacement IVF: discussions begin in USA

21 October 2013 - by Ruth Saunders

The health regulator in the USA is considering whether clinical trials of mitochondrial replacement techniques should go ahead.... [Read More]

Trial for rare 'black bone disease' wins funding

07 October 2013 - by Shanya Sivakumaran

The Alkaptonuria Society, a UK charity and patient organisation for the rare disease of the same name, has won a £5million grant from the European Commission to help finance clinical trials of a treatment for the condition... [Read More]

Ovaries 'reawakened' and baby born to early menopause mother

07 October 2013 - by Dr Lucy Freem

A new treatment to stimulate egg production from post-menopausal ovaries has resulted in the successful birth of a child after testing in a small clinical trial... [Read More]

Drisapersen trial results are not the end for exon skipping

07 October 2013 - by Robert Meadowcroft and Neil Bennett

The families of children and young people with the severe genetic muscle-wasting condition Duchenne muscular dystrophy received a heavy blow last week... [Read More]

Stem cell 'seeding' could improve reconstructive surgery

30 September 2013 - by Claire Downes

Transplanting people's own stem cells along with their fat could mean more stable transplants in reconstructive breast surgery, a small preliminary trial suggests... [Read More]

Hype, hope and headlines

30 September 2013 - by Dr Gabrielle Samuel

This event was designed to promote debate about how and when fertility research should be reported in the media, and to ask the question 'where does the responsibility lie to ensure that such reporting is not hyped?' And that it did... [Read More]

Scientists warn of potential mitochondrial replacement IVF health risks

23 September 2013 - by Dr Rosie Morley

A group of scientists has expressed concerns that it may be too soon to bring mitochondrial replacement techniques, which are still under development, to the clinic.... [Read More]

Muscular dystrophy genetic therapy falls short in major trial

23 September 2013 - by Anna Cauldwell

A highly anticipated experimental treatment for the genetic condition Duchenne Muscular Dystrophy has failed in a key test of its effectiveness in a critical phase III clinical trial.

Italian scientific panel advises against government-funded stem cell trials

23 September 2013 - by Nishat Hyder

An expert panel of scientists has issued a report advising the Italian Government against continuing to support a controversial stem cell therapy, deeming it 'unscientific'.... [Read More]

Back up your stem cells for £40,000

16 September 2013 - by Antony Blackburn-Starza

A Singaporean-based company has become the first company to offer iPS cell banking to the public... [Read More]

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