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US Congress moves to block embryo editing

06 July 2015

By Cait McDonagh

Appeared in BioNews 809

The US Congress has released a bill that would prohibit the Food and Drug Administration (FDA) from spending any money in relation to projects that involve editing the human genome.

According to a report appearing in Nature, the US House of Representatives Appropriations Committee, which funds the FDA, has proposed in its 2016 spending bill to remove funding for evaluating research or clinical applications in this area.

If passed, the legislation would also require the FDA to convene a panel of experts, including those from religious organisations, to examine a review from the Institute of Medicine (IOM) on the ethics of mitochondrial donation.

The proposed legislation comes in the wake of an announcement from Chinese scientists that they had begun research on human embryos using the CRISPR/Cas9 gene-editing technique (see BioNews 799). In recent months, this has put afterburners on the debate concerning the medical and ethical impacts of editing the human germline.

However, the Nature article raised questions over whether the implications of the bill are more political than practical; as applications to the FDA are automatically approved after 30 days unless the FDA seeks to block them, moving to block an application would require spending public funds, which the bill would prohibit.

Bioethicist Hank Greely from Stanford University, California, therefore suggests that the legislation may be a case of the Congress' Republican majority 'trying to throw a bone to some of its supporters'.

Additionally, the type of research carried out by the Chinese scientists would not have been covered by this proposed legislation as they used nonviable embryos. The US legislation would only extend to viable embryos or sperm and eggs that could be used to create a viable embryo.

Currently, US law prevents the federal government from funding research that leads to destruction of human embryos or embryos created solely for research (see BioNews 688). However, privately funded research involving editing the human germline is legal.

In April, the National Institutes of Health affirmed that gene editing of embryos falls under the Dickey-Wicker amendment, meaning that no federal funds will be made available for such research (see BioNews 800).

The bill also requires the FDA to create a committee including religious experts to examine a report that it commissioned from the IOM around the ethics of mitochondrial donation.

Jonathan Moreno, a bioethicist from the University of Pennsylvania, Philadelphia, told Nature that he couldn't understand why Congress was adding this extra layer of 'taxpayer-supported ethics reflection'. 'You don’t have to be a faith-based bioethicist to recognise that there's some global responsibility for modifying the human germline,' he commented.

However, William Kearney from the National Academy of Sciences, which oversees the IOM, commented: 'We always strive to balance our committees with the expertise necessary to carry out the study in a scientific manner in order to produce an evidence-based report.'

The bill still has a way to go to before it can become law, and will need to be approved by Congress, the Senate and then by the President to take effect.

SOURCES & REFERENCES
Nature | 01 July 2015
 
Popular Science | 29 June 2015
 
Newsweek | 30 June 2015
 
Scientific American | 29 June 2015
 
Nature | 25 June 2015
 

RELATED ARTICLES FROM THE BIONEWS ARCHIVE

07 August 2017 - by Dr Greg Ball 
Research into human germline genome editing should continue, recommends an international group of 11 human genetics organisations...
12 December 2016 - by Rachel Siden 
Stem cell therapies could be granted accelerated approval by the US Food and Drug Administration as part of a new bill passed by the Senate last week...
08 February 2016 - by Kirsty Oswald 
Clinical investigations of mitochondrial donation are 'ethically permissable', says a panel of experts reporting to the US Food and Drug Administration...
21 September 2015 - by Kirsty Oswald 
Researchers from London's Francis Crick Institute are seeking permission to edit the genome of human embryos...
14 September 2015 - by Kirsty Oswald 
The influential Hinxton group has said that the genetic modification of human embryos should be allowed...

26 May 2015 - by Ceri Durham 
Scientists will gather in the USA later this year to produce ethical guidelines on the use of human gene-editing techniques such as CRISPR/Cas9....
11 May 2015 - by Dr Calum MacKellar 
The short article by Robin Lovell-Badge entitled 'Editing human embryos' addressing the work of Junjiu Huang and colleagues in China on gene editing in human embryos - such as the use of the CRISPR/Cas9 system - raises a number of ethical questions....
05 May 2015 - by Ayala Ochert 
The US National Institutes of Health has issued a firm statement that it will not fund any research involving gene-editing technologies in human embryos...
27 April 2015 - by Ayala Ochert 
Chinese scientists report the first-ever genetic modification of human embryos using the CRISPR/Cas9 gene-editing technique, confirming rumours that these highly controversial experiments were underway...
27 April 2015 - by Professor Robin Lovell-Badge 
As Chinese scientists report the first gene editing of human embryos, is a moratorium on such practice justified?...

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CROSSING FRONTIERS

Moving the Boundaries of Human Reproduction

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8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Jacques Cohen

Dr Anna Smajdor

Dr Andy Greenfield

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross


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