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Scientists develop new 'F-class' pluripotent stem cells

15 December 2014

By Siobhan Chan

Appeared in BioNews 784

A new type of stem cell has been developed in the lab, in research described as 'groundbreaking'.

The scientists transformed adult mouse cells into induced pluripotent stem (iPS) cells that are different to any seen before.

The cells have been dubbed 'F-class' stem cells due to their 'fuzzy' appearance. They appear to multiply more rapidly and easily than other iPS cells, and they are produced when very high levels of transcription factors are added to adult cells. The researchers say it will be more economical to produce these F-class stem cells, which can be used for drug screening and disease modelling.

'We can put these cells into a big jar of media and grow them up in a suspension, which is much more efficient, cheaper, and less work to produce a huge number of cells,' said Dr Andras Nagy, who led the research.

The cells were identified during a project led by Mount Sinai Hospital’s Lunenfeld-Tanenbaum Research Institute. Scientists catalogued the stages a cell goes through as it is being reprogrammed, and in the process, uncovered a new 'state' of stem cell. Their research also highlighted the different properties that arise when certain cells and transcription factors are used.

'This project has been a real adventure for us into integrative biology in a new era of global science,' said Utrecht University's Dr Albert Heck, one of those involved in the research. 'Our group determined the faith of every protein during this process, picking up many known and novel markers for transitions to iPS cells and the new F-class stem cells.'

'What I find particularly exciting is that this opens up the idea that there may be different kinds of pluripotent stem cells,' Dr Paul Knoepfler, a stem cell biologist at the University of California, Davis, told The Scientist.

The extensive research was published in a series of five papers in Nature.

Lunenfeld-Tanenbaum Research Institute (press release) | 10 December 2014
Nature Communications | 10 December 2014
Lunenfeld-Tanenbaum Research Institute (press release) | 10 December 2014
Nature | 11 December 2014
Nature | 11 December 2014
CBC News | 10 December 2014
The Scientist | 10 December 2014
Nature Communications | 10 December 2014
Los Angeles Times | 10 December 2014
Nature Communications | 10 December 2014
Time | 10 December 2014


20 April 2015 - by Sophie McLachlan 
A new type of stem cell has been discovered that has the ability to transform into a larger number of cell types than both human embryonic and induced pluripotent stem cells...
16 February 2015 - by Dr Ross Cloney 
The emergence of stem cell research has been one of the most transformative biological advances of the last decade. In 'Good Science', Charis Thompson outlines the ethical back and forth that was often the public face of this rapidly advancing science...

15 September 2014 - by Rhys Baker 
Human pluripotent stem cells have been 'reset' to resemble embryonic stem cells at the earliest developmental state yet achieved...
01 September 2014 - by Dr Nicoletta Charolidi 
Efforts to replicate the STAP cell findings have not been successful so far, the RIKEN Institute has reported...
02 March 2009 - by Antony Blackburn-Starza 
Researchers in the UK and Canada have successfully created induced pluripotent stem (iPS) cells suitable for potential future use in humans. iPS cells are adult cells (in this case skin cells) that have been reprogrammed into a pluripotent embryonic-like state, able to divide into any cell in...
12 June 2005 - by BioNews 
Scientists at Mount Sinai Hospital in Toronto have developed Canada's first two human embryonic stem (ES) cell lines. The researchers, led by Andras Nagy, say they will share the cell lines with other stem cell scientists in Canada and abroad. Nagy said he hoped the work would 'ultimately bring Canada...

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