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RNAi  (ribonucleic acid interference)

A naturally-occurring cell process that may be exploited as a way of selectively shutting down gene activity. This involves injecting cells with short, specific pieces of  RNA, which then trigger the breakdown of a particular messenger RNA molecule.

Articles using this Glossary Item


Book Review: A Crack in Creation - Gene Editing and the Unthinkable Power to Control Evolution

21 August 2017 - by Annabel Slater

I'm glad to see a scientist engaging so strongly in public debate about the use of technology, rather than speculating on the sidelines... [Read More]

Scientists use RNAi to create gene map of 'cancer dependencies'

31 July 2017 - by Dr Molly Godfrey

A comprehensive map of genes crucial to tumour cell survival has been created by researchers... [Read More]

Ebola virus is mutating fast, gene studies find

01 September 2014 - by Siobhan Chan

The ebola virus has accumulated hundreds of mutations since the beginning of the current outbreak, researchers analysing the viral genome have found... [Read More]

Drug found effective in 'silencing' disease gene

15 July 2013 - by Matthew Thomas

A drug has been found to suppress the gene underlying a rare but fatal disease, according to results from an early-stage clinical trial... [Read More]

Cell division genes published

06 April 2010 - by Ailsa Stevens

The results of a huge multinational project to pinpoint all the genes and related proteins essential for cell division are to be made publically available for other researchers to use... [Read More]

Gene associated with age-related blindness

01 September 2008 - by Alison Cranage

Scientists working in China and the USA have identified a gene associated with dry Age-related Macular Degeneration (AMD). AMD is the most common form of visual impairment in the developed world. The research is the first time a gene has been linked with the disease, and will... [Read More]

Advance in RNA therapy technique

01 October 2007 - by Stuart Scott

RNA interference (RNAi), a genetic therapy with huge therapeutic potential across medicine, is back on track after a paper published in Nature this week. Research into the technique - which has garnered a Nobel prize and swathes of excitable column inches - suffered a setback last year when a... [Read More]

RNA Interference wins Nobel Prize

05 October 2006 - by Dr Laura Bell

Two US scientists have been awarded the Nobel Prize for Medicine for discovering a fundamental mechanism which regulates the expression of genes, called RNA interference (RNAi). Andrew Fire of the Stanford School of Medicine and Craig Mello of the University of Massachusetts Medical School won a shared... [Read More]

More new research presented at US gene therapy meeting

10 June 2006 - by Heidi Nicholl

Research ranging from tackling muscle regeneration for injured athletes to a potential cure for haemophilia has been presented at the American Society of Gene Therapy meeting at Baltimore, Maryland. A team from the University of Pittsburgh has successfully used gene therapy techniques to promote accelerated skeletal muscle... [Read More]

RNA therapy trial success

09 June 2006 - by Dr Jess Buxton

The first clinical trial based on a promising new technology called RNA interference (RNAi) has shown that it could soon be used to treat an eye disorder. The trial was designed to test the safety of the technique for treating a disease called wet age-related macular... [Read More]

Monkey cholesterol levels cut by gene silencing

29 March 2006 - by BioNews

US, Canadian and German researchers have used a novel gene therapy approach to reduce blood cholesterol levels in monkeys by more than 60 per cent. The research, published in the journal Nature, uses a technique called RNA interference (RNAi). The scientists - based at biotech firms Alnylam Pharmaceuticals and Protiva BioTherapeutics... [Read More]

ALS gene therapy success in mice

18 March 2005 - by BioNews

Two teams of researchers have successfully treated mice affected by amyotrophic lateral sclerosis (ALS), using a novel form of gene therapy. The achievement offers hope that the technique, known as RNA interference (RNAi), will lead to new therapies for a range of diseases. The scientists, based in Switzerland and the... [Read More]

Gene therapy targets cholesterol levels

11 November 2004 - by BioNews

German researchers have used a novel gene therapy approach to reduce blood cholesterol levels in mice. The research, published in the journal Nature, uses RNA - a close chemical relative of DNA. The scientists, based at biotech firm Alnylam Pharmaceuticals in Kulbach, describe their study as 'a historic step forward' in... [Read More]

Gene-based therapy for blindness?

20 September 2004 - by BioNews

The first clinical trial based on a promising new technology called RNA interference (RNAi) is set to begin in the US, to treat a progressive eye disorder. The researchers hope to test the safety of the technique for treating a disease called wet age-related macular degeneration (AMD). This condition, which... [Read More]

Gene therapy prevents brain disease symptoms in mice

07 July 2004 - by BioNews

Performing gene therapy on mice can prevent the symptoms of a hereditary brain disease called spinocerebellar ataxia (SCA). This discovery, made by a research team from the University of Iowa, US, has prompted hopes of similar treatments for related brain disorders such as Huntington's and Alzheimer's. Unlike other gene therapy... [Read More]

Advances in gene therapy research

07 June 2004 - by BioNews

Researchers gathered at the American Society of Gene Therapy meeting in Minneapolis, Minnesota last week, to hear about new approaches and techniques in this promising area of medicine. A new type of gene therapy, involving injections of 'naked DNA' generated much excitement, when University of Wisconsin scientists presented their experiments... [Read More]

Gene therapy for Huntington's disease?

17 March 2003 - by BioNews

A new study by US researchers suggests that gene therapy could be used to treat Huntington's disease (HD), a severe inherited brain disorder. Scientists at the University of Iowa have used a new technique to 'silence' the gene that makes the protein involved in HD in laboratory-grown human cells. 'When... [Read More]

New hunt for cancer genes launched

10 February 2003 - by BioNews

UK and Dutch researchers have launched a major new study to identify human genes involved in cancer. The project, funded by Cancer Research UK and the Netherlands Cancer Institute, aims to look at 10,000 of the estimated 35,000 different genes that make up the human genome. Using a powerful new... [Read More]


Events using this Glossary Item

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Published by the Progress Educational Trust


Public Conference
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Andy Greenfield

Dr Anna Smajdor

Dr Henry Malter

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross

Sandy Starr


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