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Glossary

Pharmacogenetics

An area of research that aims to develop ways of matching medicines to a person's genetic makeup, to avoid adverse reactions or non-response to particular drugs.



Articles using this Glossary Item

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ASHG warns parents to limit genetic testing

13 July 2015 - by Ceri Durham

The American Society of Human Genetics (ASHG) has cautioned against genome-wide genetic testing unless clinically indicated, especially for children... [Read More]

Personalised medicine: a reality check

05 November 2012 - by Professor Donna Dickenson

The soaring promises made by personalised medicine advocates are probably loftier than in any other medical or scientific realm today. Francis Collins, former co-director of the Human Genome Project, wrote: 'We are on the leading edge of a true revolution in medicine, one that promises to transform the traditional "one size fits all" approach into a much more powerful strategy'... [Read More]

Genetic tests that improve drug effectiveness are going neglected, warns expert

17 September 2012 - by James Brooks

Genetic tests that could greatly improve the effectiveness of drug therapy for a wide variety of conditions are being underused or ignored, a leading expert says... [Read More]

Theatre Review: Dayglo

19 March 2012 - by Dr Louisa Petchey

'Dayglo', the latest play by the Y Touring Theatre Company, skilfully and thoughtfully explores pharmacogenetics, and is much more than just another educational story...

Film Review: Genes and Life

20 February 2012 - by Ayesha Jadoon

With clear and concise information, the 'Genes and Life' DVD serves its purpose as an introduction to the field of genetics. However, it quickly became quite repetitive and lacked the entertainment value that would have taken it beyond merely an educational DVD... [Read More]

Book Review: Law and the Regulation of Medicines

18 February 2012 - by Rachel Lloyd

The principal purpose of Professor Emily Jackson's book, Law and the Regulation of Medicines, is to outline medicine's journey through UK regulation. Jackson seeks to show that those responsible for the content of the regulatory regime, and the way in which it is administered, play a crucial role in shaping the development, supply and marketing of medicines.... [Read More]

Do we think it matters where our genes come from?

09 January 2012 - by Sandy Starr

The Progress Educational Trust's 2011 project Genes, Ancestry and Racial Identity: Does It Matter Where Your Genes Come From?, supported by the Wellcome Trust, sought to debate race and ancestry in the context of genetics and to explore the connection (or lack of connection) between genetics and the concept of 'race'... [Read More]

Health disparities in the age of personalised medicine?

01 August 2011 - by Connie St Louis

The intersection of racial categories and emerging genetic technology is bound to be vexed given - for example - the long history of eugenics and segregation in the United States. Although the topic has received little attention among the UK general public, pharmaceutical companies on both sides of the Atlantic are investing huge amounts of research and development into individually tailored drugs - pharmacogenetics.... [Read More]

Will pharmacogenetics lead to colour-coded medicine?

23 May 2011 - by Nishat Hyder

'Will pharmacogenetics lead to colour-coded medicine?' was the question posed at the Progress Educational Trust (PET)'s panel discussion on 10 May 2011. This event, which is part of a wider project, 'Genes, ancestry and racial identity: Does it matter where your genes come from?' was held at the Foresight Centre, University of Liverpool... [Read More]

Book Review: Debating Human Genetics

11 October 2010 - by Rosie Beauchamp

It is almost a cliché to say that genetics has moved beyond the boundaries of science, penetrating social and cultural understandings of ourselves as individuals and social beings. Dr Alexandra Plows' book Debating Human Genetics is in this sense not a groundbreaking contribution. The book is the product of a three-year academic project. In it, Dr Plows approaches the social phenomena of the 'gene' by examining the ways different people or 'publics' are engaging with human genetics... [Read More]

Making the most of genomics for health

24 May 2010 - by Dr Philippa Brice

The 2008 'House of Lords Science and Technology Committee Report' on Genomic Medicine failed to adequately reflect the realities of genomics and health, according to a new report released on 18th May 2010... [Read More]

Genetic variant increases success of type 2 diabetes treatment

12 October 2009 - by Dr Marianne Kennedy

A genetic variation in the CYP2C9 gene is associated with how people with type 2 diabetes respond to a group of anti-diabetic drugs called sulphonylureas, according to a new study.... [Read More]

New Zealand genetic testing law review supports saviour siblings

30 October 2007 - by MacKenna Roberts

By MacKenna Roberts: A report by the Human Genome Research Project at Otago University commissioned by the New Zealand Law Foundation examines the issue of genetic testing and recommends that the laws, which currently allow testing in very limited situations, should be relaxed to allow its use for wider medical... [Read More]

'Over-the counter' genetic tests trigger ethical concerns

30 October 2007 - by Katy Sinclair

The Council of Europe has issued a protocol setting out measures that would strictly limit the use of mail order and over-the-counter genetic tests, in a bid to circumvent potential ethical dilemmas. The guidelines stipulate that diagnostic, predictive, 'healthy carrier' and pharmacogenetic tests should only be employed... [Read More]

US FDA  to subject blood-thinning drug to genetic test

20 August 2007 - by Stuart Scott

In the first move of its kind, the US Food and Drug Administration (FDA) - the agency responsible for regulating food, drugs and biological medical products - has recommended a genetic test prior to the prescription of a drug, Warfarin, in order to gauge potential patient response. Warfarin, sold... [Read More]

Pharmacogenetics in assisted reproduction: optimising response to ovarian stimulation

28 January 2007 - by Dr Alan Thornhill

Pharmacogenetics is not new. One of our authors famously can drink a bottle of wine with little effect. The other falls asleep after just one glass. Indeed, the speed at which alcohol is broken down in the body is partly genetically determined. This principle applies to most, if not all... [Read More]

Genes fuel sex drive

02 June 2006 - by Heidi Nicholl

Israeli scientists have uncovered new evidence that differences in sexual drive and desire can be correlated to particular gene variations. The team combined research into a recently discovered specific dopamine receptor (DRD4), which has been shown to induce penile erection through a central mechanism in rats, with... [Read More]

'Desk-top' machine for personalised prescriptions

10 October 2005 - by BioNews

Japanese companies have built a desk-top machine that allows doctors to check their patients' DNA before writing a prescription, the journal Nature reports. The device, which they say will be on sale for five million yen (£25,000) in a year's time, uses a single drop of blood and delivers results... [Read More]

Personalised medicine 15-20 years away, say UK scientists

22 September 2005 - by BioNews

The UK's Royal Society has published a report on the potential of pharmacogenetics - drug treatments tailored to a person's genetic make-up - following a year-long investigation into the subject. It concludes that although 'personalised medicines' have a promising future, it will be at least another 15-20 years before their use... [Read More]

Genes determine response to blood-clotting drug

12 June 2005 - by BioNews

The dose of the anti-blood clotting drug warfarin required by a patient is partly down to their genetic make-up, US researchers say. A team of scientists based at the University of Washington have shown that variations in a gene known as VKORC1 affect a person's response to warfarin. The scientists... [Read More]

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Published by the Progress Educational Trust

CROSSING FRONTIERS

Moving the Boundaries of Human Reproduction

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Jacques Cohen

Dr Anna Smajdor

Dr Andy Greenfield

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross


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