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Glossary

Mosaicism

The occurrence of two or more cell populations within a single tissue or individual, which have different genetic constitutions.



Articles using this Glossary Item

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Preimplantation genetic screening: unvalidated methods discard healthy embryos

11 December 2017 - by Norbert Gleicher

A seemingly brilliant hypothesis of preimplantation genetic screening arose in the 1990s when Dr Yuri Verlinsky proposed using polar body biopsies to detect chromosomal abnormalities in embryos prior to transfer in IVF... Healthy embryos are discarded by unvalidated PGS

Genome editing targets beta-thalassemia in human embryos

02 October 2017 - by Dr Rachel Brown

A genome editing technique called 'base editing' has been used to correct the mutation causing the inherited blood disorder beta-thalassemia in human embryos... [Read More]

We need to talk about... CRISPR

21 August 2017 - by Giulia Cavaliere

Picture this - it's the last day in the office before the summer holidays, you're looking forward to some sunshine and warmth, email auto-response set, and all ready to go. Then, all of a sudden: the news... [Read More]

Disease-causing mutation edited out of human embryos

07 August 2017 - by Charlotte Spicer

Scientists have published their study confirming they are the first to correct a disease-causing mutation in human embryos using genome editing... [Read More]

US lab may have edited human embryos for first time

31 July 2017 - by Charlotte Spicer

Scientists in the US may have successfully used genome editing in human embryos to correct disease mutations, according to a report by MIT Technology Review... [Read More]

First genome editing of normal human embryos

13 March 2017 - by Dr Katie Howe

Chinese scientists have successfully used genome editing to correct mutations in viable human embryos for the first time... [Read More]

IVF culture medium can double the chance of success

09 January 2017 - by Annabel Slater

The type of culture media used in IVF can more than double the chance of producing healthy embryos and significantly affect chances of successful conception... [Read More]

IVF: the next generation – first UK baby born after DNA screening technique

09 May 2016 - by James Brooks

The UK's first baby resulting from an embryo that was screened using next-generation DNA sequencing has been born in Oxford... [Read More]

Reassurance for mothers over mosaic aneuploidy in CVS

03 May 2016 - by Professor Magdalena Zernicka-Goetz

Although our recent findings on the fate of aneuploid cells in mosaic embryos have indeed been somewhat misrepresented in the press, our findings may still constitute a strand of hope for mothers who have had early test results showing mosaic aneuploidy... [Read More]

Abnormal fetuses are highly unlikely to heal themselves

18 April 2016 - by Professor Caroline Ogilvie

Press coverage of a recent study on mouse embryos speculates that termination of human pregnancies diagnosed with aneuploidy (a family of conditions including Down's syndrome) at prenatal diagnosis could be unnecessary, due to the ability of the fetus to 'heal itself'. In fact, the paper's findings are not relevant to aneuploidy detected at prenatal diagnosis... [Read More]

Birthmark gene find offers hope for rare neurological condition

13 May 2013 - by Dr Linda Wijlaars

A genetic mutation responsible for both Sturge-Weber syndrome, a rare neurological disorder, and 'port-wine stain' birthmarks, has been identified... [Read More]

Why we should back a law change to allow mitochondrial transfer into the clinic

13 February 2012 - by Dr Kristina Elvidge

Mitochondrial diseases are soon to be brought to the attention of the general public, as the Government seeks to gauge the attitude of the nation towards a ground-breaking IVF treatment that could prevent these conditions being passed from mother to child... [Read More]

New PGD technology guidelines published for the genetic testing of IVF embryos

01 November 2010 - by MacKenna Roberts

The European Society of Human Reproduction and Embryology (ESHRE) has published an updated set of best practice guidelines for fertility clinics on the use of preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) techniques... [Read More]

What next for preimplantation genetic screening (PGS)?

13 July 2009 - by Dr Joyce Harper

Preimplantation genetic screening (PGS) for aneuploidy was first reported by Verlinsky et al (1995) and Munne et al (1995). Both of these initial studies analysed polar bodies. The aim of the technique is to help determine the best IVF embryo for transfer on the grounds of the polar body or embryo's chromosomes, by performing biopsy and analysis of the chromosomes using fluorescent in situ hybridisation (FISH). There have been hundreds of papers on the use of PGS. It is well known that for pa... [Read More]

PGS: It ain't what you do it's the way that you do it...and that's what gets results

17 July 2007 - by Dr Alan Thornhill

Embryo selection following cleavage stage embryo biopsy and chromosome analysis to identify aneuploid embryos (those which have an abnormal number of chromosomes) in every couple having IVF/ICSI or all women of advanced maternal age is rightly considered by most clinics to be too invasive and potentially damaging for routine... [Read More]

FISHing for trouble?

04 December 2006 - by Paul Scriven

Make a habit of two things - to help, or at least to do no harm' (Attr Hippokrates of Kos). The principle of preimplantation testing for sporadic chromosome aneuploidy (preimplantation genetic screening, PGS) to improve the reproductive efficiency of assisted conception for couples at increased risk is a sound one. It... [Read More]

PGS: select or reject? - it's not just about improving pregnancy rates

20 November 2006 - by Professor Alan Handyside

Ten years since the first reports of preimplantation genetic diagnosis for abnormal chromosome number, or aneuploidy, (now commonly known as PGS - preimplantation genetic screening), we are experiencing a prejudicial mistrust of a clinical approach that is generally accepted to be scientifically and clinically sound. Opponents of PGS frequently criticise its... [Read More]

Transgenic fish created using GM sperm

28 January 2004 - by BioNews

A team of Japanese and US researchers has managed to create transgenic zebrafish, using genetically-modified sperm grown in the laboratory. Researchers at the Fukui Prefectural University in Obama, Japan and the US National Human Genome Research Institute (NHGRI), say their findings have implications for a wide range of research areas... [Read More]

Remixing reproduction and genetics

05 July 1999 - by Professor Marcus Pembrey

The European Society of Human Reproduction and Embryology (ESHRE) held their annual meeting in Tours last week. The European Society of Human Genetics (ESHG) held theirs in Geneva at the end of May. However, these two clinical and academic disciplines - until now rather separate - are becoming increasingly integrated. In the... [Read More]

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