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FISH (fluorescence in situ hybridisation)

A laboratory technique that uses fluorescent-labelled pieces of DNA to detect specific genes, chromosome segments or chromosomes, in cells examined under a special microscope.

Articles using this Glossary Item

Preimplantation genetic screening: unvalidated methods discard healthy embryos

11 December 2017 - by Norbert Gleicher

A seemingly brilliant hypothesis of preimplantation genetic screening arose in the 1990s when Dr Yuri Verlinsky proposed using polar body biopsies to detect chromosomal abnormalities in embryos prior to transfer in IVF... Healthy embryos are discarded by unvalidated PGS

Reply to Mertes, Repping and de Wert 'Stating the obvious: discarding embryos does not increase your chance of having a baby'

22 February 2016 - by The signatories of the COGEN Consensus Statement

It is clear from the reply of Mertes et al in BioNews 835 to the COGEN Consensus Statement on preimplanation genetic screening that some controversy still remains regarding the benefits of PGS... [Read More]

New PGD technology guidelines published for the genetic testing of IVF embryos

01 November 2010 - by MacKenna Roberts

The European Society of Human Reproduction and Embryology (ESHRE) has published an updated set of best practice guidelines for fertility clinics on the use of preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) techniques... [Read More]

What next for preimplantation genetic screening (PGS)?

13 July 2009 - by Dr Joyce Harper

Preimplantation genetic screening (PGS) for aneuploidy was first reported by Verlinsky et al (1995) and Munne et al (1995). Both of these initial studies analysed polar bodies. The aim of the technique is to help determine the best IVF embryo for transfer on the grounds of the polar body or embryo's chromosomes, by performing biopsy and analysis of the chromosomes using fluorescent in situ hybridisation (FISH). There have been hundreds of papers on the use of PGS. It is well known that for pa... [Read More]

FISHing for trouble?

04 December 2006 - by Paul Scriven

Make a habit of two things - to help, or at least to do no harm' (Attr Hippokrates of Kos). The principle of preimplantation testing for sporadic chromosome aneuploidy (preimplantation genetic screening, PGS) to improve the reproductive efficiency of assisted conception for couples at increased risk is a sound one. It... [Read More]

Concern over proposed prenatal screening changes

30 June 2005 - by BioNews

New recommendations for prenatal screening programmes to detect Down syndrome could lead to some chromosome abnormalities being missed, UK researchers say. A team based at Salisbury District Hospital looked at the likely effect of the proposal to scrap a type of testing called karyotyping in favour of newer, rapid methods... [Read More]

Events using this Glossary Item

PGD for Reciprocal Translocation Cases: State of the ART
16 October 2012 
A webinar introduced by Dr Tony Gordon, Director of 24sure at BlueGnome...

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