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Glossary

Chimera

An organism (or tissue) composed of a mixture of genetically distinct cells, formed by processes such as fusion of early embryos, grafting, or mutation.



Articles using this Glossary Item

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US scientists create first human-pig embryo chimeras

30 January 2017 - by Annabel Slater

The first early human–pig embryo chimeras have been created by researchers at the Salk Institute, California... [Read More]

Shortage of organs for transplantation – is more research on human–animal chimeras the right approach?

12 September 2016 - by Dr Silvia Camporesi and Giulia Cavaliere

By focusing all our attention on the ethics of human–animal hybrids, we may be overlooking non-technical solutions to the short supply of human organs for transplantation... [Read More]

Bioethical framework for human-animal embryo research proposed

05 September 2016 - by Anneesa Amjad

A prominent bioethicist in the USA has suggested that most of the ethical concerns surrounding the creation of animal-human chimera embryos using human pluripotent stem cells could be reasonably addressed... [Read More]

NIH to lift moratorium on human–animal chimera research

08 August 2016 - by Antony Blackburn-Starza

The US National Institutes of Health is considering lifting a ban on the funding of research to create human-animal 'chimeras' and replacing it with an ethical review process... [Read More]

Pig-human organs: policing the moral boundaries

20 June 2016 - by Dr Anna Smajdor

The recent of creation of pig embryos with human DNA blurs the boundaries between animals and ourselves, giving us a chance to consider whether our moral categories are correct... [Read More]

US lab attempting to grow pig embryos with human pancreases

13 June 2016 - by Dr Jane Currie

Scientists have used CRISPR to create part-pig, part-human embryos in an attempt to grow human organs for transplant... [Read More]

Call to end US federal funding ban on chimera research

09 November 2015 - by Dr Jane Currie

A group of researchers have called for an overturn of a recent decision by the National Institutes of Health to suspend funding for research on human–animal chimeras... [Read More]

Man fails paternity test due to passing on unborn twin's DNA

02 November 2015 - by Jessica Richardson

A man discovered he was not the genetic father of his child, due to a rare form of chimerism that means some of his cells carry a genome belonging to an unborn twin who died in the womb... [Read More]

New type of stem cell may help grow organs

11 May 2015 - by Dr Tamara Hirsch

Scientists have identified a new type of stem cell that shows distinct advantages over those discovered to date, and which could potentially be used to grow human organs in animals such as pigs or cows... [Read More]

Teenager uncovers genetics behind her own rare cancer

03 March 2014 - by Rhys Baker

A recovering teenage cancer patient is a lead author of a study into the rare form of liver cancer she contracted. The research, published in Science, identified a key mutation that may explain the uncontrolled growth of the tumour... [Read More]

Cancer-killing cells work well in mice

19 August 2013 - by Siobhan Chan

Human stem cells have been reprogrammed to form cancer-targeting immune cells that were shown to stop tumour growth in mice... [Read More]

Safety of stem cells supported by mouse study

14 January 2013 - by Dr Anna Cauldwell

Tissue derived from induced pluripotent stem cells causes 'limited or no immune response' in mice, a study published in Nature has found... [Read More]

Book Review: Chimera's Children - Ethical, Philosophical and Religious Perspectives on Human-Nonhuman Experimentation

07 January 2013 - by John Brinsley

Mythical ideas of 'chimera', or animals formed or forged of parts derived from various different organisms, have endured throughout history, from Greek folklore and Homer's Iliad through to contemporary science fiction. In fact, organisms arising from human-nonhuman genetic combinations are already with us... [Read More]

First chimeric monkeys born in US

09 January 2012 - by Suzanne Elvidge

Three chimeric rhesus monkeys born in the USA have been described as the world's first primate chimeras... [Read More]

Aligning research legislation: interspecies embryos and animals containing human material

10 October 2011 - by Tara Camm

In 2008, important changes were made to the legislation governing the use of human embryos in research, the UK Human Fertilisation and Embryology Act (HFE Act) 1990. The legislation was extended to five categories of 'human admixed embryos' containing human and animal cellular or genetic components, which were brought within the licensing regime of the HFE Act... [Read More]

Scientists, hybrid embryos and the media

28 April 2008 - by Fiona Fox

Should scientists enter the media fray on the most controversial aspects of stem cell research when the row is clearly about much more than the science? This is a question that many in the scientific community have raised over the past year in relation to the furore over human-animal hybrid... [Read More]

Reprogramming adult epithelial cells into embryonic-like stem cells improves therapeutic safety

19 February 2008 - by MacKenna Roberts

Japanese researchers announced last week that they have advanced their understanding and ability to safely 'reprogramme' adult stem cells to resemble embryonic stem (ES) cells without inducing tumours or harmful genetic abnormalities. The Japanese team of researchers, lead by Dr Shinya Yamanaka at Kyoto University, reprogrammed liver... [Read More]

Reproducing regulation: issues arising from the Human Tissue and Embryos (Draft) Bill

03 September 2007 - by Professor Marcus Pembrey

A Parliamentary committee has recently challenged several proposals in the UK Government's draft revised legislation for assisted reproduction and embryo research, published earlier this year. These areas of biomedical research and personal reproductive decisions raise important ethical and social issues. As such, the committee report is welcome, because it re-opens... [Read More]

From consensus to plurality: the negotiated compromise and public consultations

23 July 2007 - by Antony Blackburn-Starza

The University College London's Law and Bioethics colloquium, which took place in London at the beginning of July, gave me the impression that a silent revolution is taking place in bioethical discourse (1). The goalposts in bioethics may be shifting from an emphasis on trying to build a moral consensus... [Read More]

Embryos, hybrid embryos and UK law

10 April 2007 - by Dr John Gillott

The House of Commons Science and Technology Committee's report, 'Government Proposals for the Regulation of Hybrid and Chimera Embryos', is its response to two related events: firstly the UK Government's intention to outlaw the creation of such entities, announced in December 2006 in its White Paper (1), and secondly the... [Read More]

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Events using this Glossary Item

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Published by the Progress Educational Trust

CROSSING FRONTIERS

Moving the Boundaries of Human Reproduction

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Jacques Cohen

Dr Anna Smajdor

Dr Andy Greenfield

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross


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