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King's College London - Health: More than a medical matter

Glossary

Allele

Alternate forms of gene at a particular chromosome location - the gene governing ABO blood type, for example - or indeed any alternative DNA sequence at a particular chromosome location.



Articles using this Glossary Item

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Gene therapy could be 'functional cure' for HIV

10 March 2014 - by Dr Lanay Tierney

A potential HIV therapy where patients have their blood cells genetically modified to help them resist the virus is safe and promising as a treatment, say researchers after a small clinical trial... [Read More]

Why rare disease research isn't just about rare diseases

18 November 2013 - by Oliver Timmis

The idea of a rare disease informing wider knowledge about fundamentals of biology is now well established. We have shown it in alkaptonuria research, as alkaptonuria (which affects around 80 people in the UK) is an extreme form of osteoarthritis (which affects more than eight million)... [Read More]

'Til our genes do us part: secret to a happy marriage may lie in DNA

14 October 2013 - by Dr Lanay Tierney

Researchers in the USA may have come up with some of the first evidence linking genes, emotion and marital satisfaction... [Read More]

Event Review: It's All in the Genes - Medical Genetics in Obstetrics and Gynaecology

28 May 2013 - by David O'Rourke

Medical genetics has changed how we think about diagnosis and treatment in almost every field of medicine. At an evening event hosted by the Royal Society of Medicine (RSM), medical genetics teamed up with obstetrics and gynaecology to explore the impact of genetics on the diagnosis of ovarian and breast cancer.... [Read More]

Gene variant may explain increased flu severity among Chinese

04 February 2013 - by Matthew Thomas

A genetic variant frequently found in Chinese populations may explain why severe complications from swine flu are more common in China. The discovery may also have implications for other influenza virus strains and help scientists understand why flu outbreaks hit some populations harder than others.... [Read More]

'Marry out?' Some surprising consequences of genetic disease risk among Ashkenazi Jews

28 May 2012 - by Dr Jessica Mozersky

Ashkenazi Jews have historically been an endogamous population. Marrying within the group remains important to many Jews because endogamy is seen as one way to preserve Judaism and ensure the survival of future generations. In the wake of the Holocaust, and amidst a steadily decreasing Jewish population, Jewish survival has great cultural relevance... [Read More]

Higher birth weight linked to mum's genes

26 March 2012 - by Dr Daniel Grimes

A gene variant passed down from the mother has been linked to heavier newborns, according to scientists... [Read More]

Genetic pseudoscience races to the bottom

26 March 2012 - by James Brooks

Newspapers overhype mediocre science all the time. You know this, I know this. But all the same a story in the Sunday Times a couple of weeks ago managed to hit a new low for uncritical reporting... [Read More]

Podcast Review: Expert Explanations - Evolutionary Genetics/Genetics

20 February 2012 - by Rachel Lyons

The Pulse-Project is a website which offers a wide range of freely accessible audio and video lectures on the sciences and medical humanities... [Read More]

Single gene can make you appear more trustworthy

21 November 2011 - by James Brooks

Variations in a single gene may have considerable impact on whether people come across as trustworthy and kind, scientists say. Furthermore, the snap judgments we make about people's kindness after only a brief contact may accurately correspond to whether or not they possess the more 'social' gene variant... [Read More]

Genetic regions linked to schizophrenia by two Chinese studies

07 November 2011 - by Dr Nadeem Shaikh

Two Chinese genome wide association studies (GWAS) have identified genomic regions linked to the incidence of schizophrenia. The papers, published in Nature, are some of the first GWAS to look at Chinese as opposed to Western populations.... [Read More]

TV Review: Horizon - Are You Good or Evil?

19 September 2011 - by Suzanne Elvidge

Good and evil have always been moral perspectives, but this edition of BBC One's science programme Horizon has pulled them firmly into the scientific realm, with an analysis of the science behind good and evil.... [Read More]

Health disparities in the age of personalised medicine?

01 August 2011 - by Connie St Louis

The intersection of racial categories and emerging genetic technology is bound to be vexed given - for example - the long history of eugenics and segregation in the United States. Although the topic has received little attention among the UK general public, pharmaceutical companies on both sides of the Atlantic are investing huge amounts of research and development into individually tailored drugs - pharmacogenetics.... [Read More]

Human history is written in everyone's genome

18 July 2011 - by Mehmet Fidanboylu

Two scientists claim to have pushed the boundaries of what can be learned about the ancestral history of the human race from one person's genome. Dr Richard Durbin and Dr Heng Li from the UK's Wellcome Trust Sanger Institute in Cambridge used information from the genomes of only seven individuals... [Read More]

Event review: Music from the Genome

19 July 2010 - by Dr Vivienne Raper

Imagine singing a piece of your DNA. 'A', 'C' and 'G'- the first three letters of your genetic code - are easy because they have corresponding musical notes. The fourth letter, 'T', looks harder, but you can use 'ti' on the musical scale. Think 'tea' in the song 'Doe a deer, a female deer, Ray, a drop of golden sun… Tea, a drink with jam and bread'... [Read More]

Study suggests gene linked to credit card debt

10 May 2010 - by Rosemary Paxman

Our genetic make-up may influence the likelihood of running into debt, UK and US researchers have found, according to the LSE research magazine.... [Read More]

Gene-ecology interactions and psychological disorders

26 April 2010 - by Dr Tom Dickins and Sima Sandhu

The models emerging from behavioural biology are increasingly sophisticated. They do not undermine the quest for candidate genes, but rather augment our understanding of why those genes might persist in populations and be differentially expressed across circumstances.... [Read More]

Cholesterol control gene could provide dementia protection

18 January 2010 - by Alison Cranage

American scientists have found that a genetic variation could be associated with slower memory decline and a lower risk of Alzheimer's disease and dementia. The preliminary findings shed light on processes in the brain that could contribute to memory loss and dementia. The work was published in the Journal of the American Medical Association last week.... [Read More]

TV Review: Is It Better to Be Mixed Race?

23 November 2009 - by Monica Mascarenhas

Channel 4, Monday 2 November 2009... [Read More]

The new epigenetics

09 November 2009 - by Professor Marilyn Monk

All cells in the body have the same complement of 25000 genes, yet different cells in different specific tissues - such as nerve, muscle or gut - have different characteristics phenotype. It follows that different subpopulations of genes within cells of differing function must be active or silenced depending on requirements for function in a particular tissue. Obviously, there will be genes concerned with metabolism, growth, and cell division - the so-cal

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