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Glossary

BRCA2

A gene on chromosome 13, which instructs the cell to make a protein that normally helps to repair damaged DNA and suppress cell growth. A person who inherits certain mutations in a BRCA2 gene has a higher risk of getting breast cancer, ovarian cancer and certain other types of cancer.



Articles using this Glossary Item

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BRCA gene does not affect survival in those treated for breast cancer

15 January 2018 - by Hannah Somers

A new study has found that BRCA gene mutations do not affect the survival rates of breast cancer patients under 40... [Read More]

Seventy-two new gene targets for breast cancer found

30 October 2017 - by Annabel Slater

Two studies have discovered 72 new genetic variants associated with the risk of developing breast cancer... [Read More]

Gene test could improve prediction of breast cancer risk

16 October 2017 - by Hannah Somers

A new genetic test to accurately predict an individual's risk of developing breast cancer will soon be rolled out at two hospital clinics in Manchester... [Read More]

Researchers crack how BRCA1 gene raises cancer risk

09 October 2017 - by Dr Loredana Guglielmi

A major breakthrough in understanding how mutations in the BRCA1 gene raise cancer risk has been made by researchers in the USA... [Read More]

Lifetime cancer risk predicted for BRCA mutation carriers

26 June 2017 - by Lea Goetz

A study of almost 10,000 women carrying BRCA mutations has revealed the best estimate yet of their risk in developing breast and ovarian cancer... [Read More]

Liquid biopsy may help target prostate cancer treatment

26 June 2017 - by Charlotte Spicer

A new three-in-one blood test could progress personalised treatment for patients with prostate cancer... [Read More]

Ovarian cancer drug could treat BRCA-related breast cancer

12 June 2017 - by Dr Loredana Guglielmi

A drug treatment for ovarian cancer has shown success against inherited breast cancer... [Read More]

Cancer-causing effect of common chemical pinpointed

05 June 2017 - by Shaoni Bhattacharya

A common chemical found in household products could increase the risk of cancer by blocking the ability of cells to fix genetic flaws which lead to the disease... [Read More]

Existing drugs could benefit one in five breast cancer patients

20 March 2017 - by Dr Molly Godfrey

A genetic study of breast cancer patients suggests that existing drugs for treating rare breast and ovarian cancers may help more patients than previously thought... [Read More]

New genetic links to pancreatic cancer discovered

20 February 2017 - by Jamie Rickman

Researchers have used whole-genome sequencing to uncover new mutations responsible for a rare type of pancreatic cancer... [Read More]

BRCA testing not offered to enough high-risk patients

13 February 2017 - by Hannah Somers

A study has indicated that US doctors may not be recommending genetic testing to a sufficient number of high-risk breast cancer patients... [Read More]

Genetic fingerprint identifies aggressive prostate cancer

16 January 2017 - by Annabel Slater

Canadian scientists have identified a genetic fingerprint that indicates which prostate cancer tumours may develop into a more aggressive form of the disease after treatment... [Read More]

More women get tested for breast cancer genes thanks to 'Angelina Jolie effect'

19 December 2016 - by Anastassia Bolotkova

Angelina Jolie's 2013 public announcement that she has the BRCA1</i> breast cancer gene led to a 64 percent increase in women seeking genetic testing for breast cancer... [Read More]

FDA warns against ovarian cancer screening tests

12 September 2016 - by Anastassia Bolotkova

The FDA has warned that it does not recommend the use of any currently available ovarian cancer screening tests to detect the disease... [Read More]

Gene testing in young patients may uncover 'cancer families'

08 August 2016 - by Amina Yonis

More than half of patients with sarcoma, a rare cancer, have mutations that are known to increase the risk of other types of cancer... [Read More]

Quick and cheap DNA tests for ovarian cancer patients 'would save lives'

18 July 2016 - by Hannah Somers

Researchers have developed a new pathway for genetically testing ovarian cancer patients which they say will save both lives and money... [Read More]

BRCA mutations linked to prostate and uterine cancers

11 July 2016 - by Antony Blackburn-Starza

Genetic mutations on several genes including BRCA2 have been associated with prostate cancer; while in a separate study, a BRCA1 mutation has been linked to a particular form of uterine cancer... [Read More]

BRCA database now holds data on 6200 variants

06 June 2016 - by Dr James Heather

After one year of existence, the BRCA Share database has released details on its progress in collating information on variants of the BRCA1 and BRCA2 genes... [Read More]

Myriad: Patients seek right to access personal genetic information

23 May 2016 - by Antony Blackburn-Starza

Myriad Genetics has been hit by a complaint filed by the American Civil Liberties Union (ACLU) on behalf of four patients who are seeking a right of access to all their genetic information held by the company... [Read More]

No benefit from expanding cancer-risk gene test beyond the essentials

09 May 2016 - by Rachel Siden

Adding more genes to existing multi-gene panels that test for breast and ovarian cancer risk offers little clinical benefit, a study says... [Read More]

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