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More research into male infertility is needed

05 January 2004

By Professor Allan Pacey

Appeared in BioNews 239
Male infertility has been in the news again this week, with journalists pouncing on some data presented at the joint meeting of the Association of Clinical Embryologists and the British Fertility Society in Liverpool. What caught the media's attention was a report from researchers in Aberdeen who had presented preliminary data that suggested that the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. This immediately set alarm bells ringing in newsrooms across the country with journalists asking if this would mean that in a few years time many more couples would require IVF (or ICSI) in order to reproduce. Whilst such scare-mongering is not helpful, the story did help to put back on the agenda the debate as to whether sperm counts are actually declining, as well as the subject of male infertility which is too often overlooked.

Of course, the suggestion that sperm counts may be declining is not a new one, and scientists have debated the hypothesis many times since the 1950's. But the publication of a paper by Elizabeth Carlson in the British Medical Journal in 1992 initiated a popular interest in the topic by journalists and the public alike. Many authors have since reported either how they have observed in their clinics a decline in sperm concentration in recent years (giving support to the hypothesis), or reported no apparent change (therefore refuting it). As such, the data is tantalisingly complex for all but the specialist reader and it is no wonder that journalists and some scientists are often confused by it.

What seems to be clear is that the factors that control and influence male fertility are unsurprisingly complex. Too many studies rely on the analysis of retrospective (archival) data, an approach that is laudable but fraught with potential biases. For example, the techniques for analysing semen in the laboratory have changed markedly over the past 20 years and an increasing emphasis on quality control could account for the some of the differences observed in some studies. In addition, men are now more willing to come forward for semen analysis than they were even a few years ago. This is because there is a greater social acceptability of infertility and also because there are now more treatment options available to overcome male fertility that were simply not available even 10 years ago (e.g. ICSI). As such, it may be a long time before we fully understand whether sperm counts are actually on the decline and, if so, what the cause of this might be.

Studies such as the one from Aberdeen are important pieces of a complex jigsaw, but what is required are more in-depth prospective studies which investigate the reproductive health of men in advance of attempts to conceive and possibly even from early in their adult or adolescent life. Such approaches are not cheap and will require significant funding. But surely now is the time to start such work so that if male fertility is under assault from factors unknown we have time to take preventative action?

Dr Allan Pacey is Senior Lecturer in Andrology at the University of Sheffield



08 May 2006 - by Dr Kirsty Horsey 
French researchers have published a study showing new evidence that male fertility declines as they get older. The study's authors, who published their findings in the journal Fertility and Sterility, warn that men's lack of awareness of this fact - and of their own biology - may play...
16 September 2005 - by BioNews 
A study for Norwich Union Healthcare has shown that more than 2.5 million men in the UK could have fertility problems. The researchers asked doctors in general practice (GPs) about male infertility, finding that a nearly a third of them worried that declining male fertility will impact on an already...

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