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Stem cell 'seeding' could improve reconstructive surgery

30 September 2013

By Claire Downes

Appeared in BioNews 724

Transplanting people's own stem cells along with their fat could mean more stable transplants in reconstructive breast surgery, a small preliminary study suggests.

Dr Stig-Frederik Trojahn Koelle, from Copenhagen University Hospital, one of the authors of the research, published in the Lancet, says the results 'suggest that stem-cell enriched fat grafting might prove to be an attractive alternative to major tissue augmentation, such as breast reconstruction after cancer [...], with fewer side effects and more satisfying cosmetic results'.

The new technique builds on the more established method of 'lipofilling', where a patient's own fat is removed using liposuction and then transplanted to increase the volume in fat in another area of the body.

But, Dr Koelle told US News, lipofilling can be 'unpredictable, and you often have to repeat the procedure to get a [satisfactory] result'. One major problem is 'resorption', where transferred fat does not survive for very long after the operation. Up to 80 percent of transferred material can be lost in this way.

Dr Koelle and his team tested the new technique in ten healthy volunteers. Following liposuction to collect fat tissue, two fat grafts were prepared for each participant to be injected into the upper arm. One fat graft was enriched with their own stem cells and the other without.

After 121 days, stem cell enriched grafts retained over 80 percent of their initial volume, compared to 16.3 percent for the non-enriched grafts. Higher amounts of newly formed connective tissue and lower rates of tissue death were also observed in the stem cell grafts.

Dr J Peter Rubin, chair of plastic surgery at the University of Pittsburgh Medical Center, and a co-author of an editorial accompanying the study, told US News that the results were a 'proof of principle' and would need to be followed up with more substantial trials.

He added that successful animal studies using the technique had already been carried out. 'What's been missing is good data on humans', he said.

RELATED ARTICLES FROM THE BIONEWS ARCHIVE

14 October 2013 - by Dr Greg Ball 
Large-scale production of liver and pancreas cells is becoming a possibility, as scientists have developed a cell culture method allowing stem cells to grow in the laboratory...

18 March 2013 - by Sarah Pritchard 
Stem cells taken from patients' own fat tissue could potentially be used to deliver treatments direct to brain tumours, say scientists after early laboratory tests...
07 January 2013 - by Dr Linda Wijlaars 
Bone fragments were removed from the eyelid of a woman after a facelift that used her own stem cells yielded some unexpected results...
30 July 2012 - by Dr Greg Ball 
Adult stem cells extracted from liposuctioned fat have been used to grow new blood vessels, according to scientists presenting their work at a conference. The researchers hope that one day their technique could be used in vascular surgery...
16 November 2009 - by Dr Charlotte Maden 
Scientists in Australia have developed a way for women diagnosed with breast cancer to regrow their breasts after a mastectomy. The group at the Bernard O'Brien Institute of Microsurgery in Melbourne plan to start clinical trials with the technique next year. It is believed that this will be only the second time in the world that tissue engineering has been carried out in a human....

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