Subscribe to the BioNews newsletter for free

Login
Advanced Search

Search for
BioNews

Like the Progress Educational Trust on Facebook


The Fertility Show


 

Scents and sense ability: genes may influence perception of smell

05 August 2013

By Matthew Thomas

Appeared in BioNews 716

Whether a smell strikes you as fragrant or fetid – or if you even notice it at all – may be influenced by your genes, according to a pair of studies.

Four chemical compounds commonly found in foods are associated with specific areas of the genome. Researchers from the New Zealand Institute for Plant and Food Research uncovered genetic differences predicting a person's ability to sniff out malt, apples, blue cheese and violets.

The team further probed the compound underlying a violet's aroma – β-ionone – in a separate study. They uncovered a mutation in a single gene that can affect people's ability to detect β-ionone in food and beverages.

'This might mean that when people sit down to eat a meal, they each experience it in their own personalised way', says Dr Jeremy McRae, who was involved in both studies.

The researchers tested how sensitive 187 people were to ten chemical compounds. Participants chose between three water-filled wine glasses, one of which also contained one type of smelly molecule. Participants had to select the odd one out: the aromatic glass.

The team then looked for variations in the participants' genomes linked to their abilities to smell each of the ten odours. The genome-wide association study (GWAS) highlighted regions of DNA statistically associated with four of the compounds. These regions were located within or near clusters of odorant receptor genes.

'We were surprised how many odours had genes associated with them. If this extends to other odours, then we might expect everyone to have their own unique set of smells that they are sensitive to', said McRae.

A separate GWAS analysis found that a change in a single letter in the odorant receptor gene OR5A1 affected people's ability to distinguish β-ionone. With one version of the gene, participants were more likely to pick up β-ionone's 'pleasant floral note'. People with another mutation found the scent 'sour' or 'pungent'.

OR5A1 is one of nearly 400 odorant, or olfactory, receptor genes present in humans. These genes produce proteins that sit on sensory nerves in the nose, catching different molecules from the air and signalling the brain. These signals lead to the perception of smell.

Dr Richard Newcomb, senior author on both studies, told Nature: 'All of these genes are on different chromosomes, acting independently, so all these different people – even just for these four compounds – are having totally different experiences of the chemical world through their sense of smell'.

RELATED ARTICLES FROM THE BIONEWS ARCHIVE

10 September 2012 - by Holly Rogers 
Scientists have restored the sense of smell in mice using a gene therapy designed to repair the cilia - hair-like formations on nasal cells that are important in olfaction...
05 March 2012 - by Dr Kimberley Bryon-Dodd 
A chemical that causes bad breath may help convert stem cells into liver cells, according to scientists in Japan...
09 April 2001 - by BioNews 
Researchers from the University of Texas at Austin have established that men find that women smell particularly pleasant during the fertile periods of their menstrual cycle. Seventeen women participated in the study which was designed to establish what sort of odour a woman gives off at different times of her...

HAVE YOUR SAY
Be the first to have your say.

You need to or  to add comments.

By posting a comment you agree to abide by the BioNews terms and conditions


- click here to enquire about using this story.

Published by the Progress Educational Trust

CROSSING FRONTIERS

Moving the Boundaries of Human Reproduction

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Jacques Cohen

Dr Anna Smajdor

Dr Andy Greenfield

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross


BOOK HERE

Good Fundraising Code

Become a Friend of PET HERE and give the Progress Educational Trust a regular donation