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Gene therapy for osteoarthritis in mice

18 March 2013

By Reuben Harwood

Appeared in BioNews 697

An experimental gene therapy that protects cartilage from wear and deterioration has been shown to slow the development of osteoarthritis in mice.

Osteoarthritis is the most common form joint disease affecting over 8 million people in the UK. It is caused by the breakdown of cartilage, the slippery connective tissue between bones, due to age or injury. Without this protective layer, friction between the bones in joints causes the pain experienced by people with the condition.

Currently there is no cure for osteoarthritis, but a variety of treatments are available to manage the symptoms of the disease. For advanced cases, where physiotherapy and pain relief are ineffective, operations to replace the damaged joint with an artificial one can be performed. But the treatment is expensive – a hip replacement can cost the NHS) between £4

Express | 14 March 2013
WRBL News 3 | 14 March 2013
Everyday Health | 13 March 2013
Science Translational Medicine | 13 March 2013


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15 January 2005 - by BioNews 
A gene crucial for making cartilage could be involved in osteoarthritis, say Japanese researchers. Scientists at the Institute of Physical and Chemical Research (RIKEN) have found that a mutated version of a gene called ASPN is more common in people with osteoarthritis. The disease, which affects more than five per...

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