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Human kidney tissue successfully grown from stem cells

28 January 2013

By Michelle Downes

Appeared in BioNews 690

In what is thought to be a first, stem cells have been used to generate human kidney tissue.

Experiments led by Dr Kenji Osafune at Kyoto University in Japan, used human induced pluripotent stem cells, which can be programmed to become any of the cells in the body. The scientists first grew a kind of tissue called intermediate mesoderm - a middle point between the stem cells and specialised kidney tissue.

'There are about 200 types of cells in the human body, but this tissue grows into only three types of cells', Dr Osafune told AFP. As well as kidney cells, intermediate mesoderm tissue can develop into adrenal cells or reproductive gland cells.

From the intermediate mesoderm, the scientists were able to generate part of the urinary tubule, which is important in the production of urine.

The study is significant because it points towards future clinical applications. Kidney tissue cannot regenerate or repair itself and currently patients with damaged or diseased kidneys rely on time-consuming dialysis until they are matched with an organ donor.

Kidney transplantation is far from risk-free and donor shortages are widespread. Even successful transplant patients require another transplant after 10-15 years.

Dr Osafune stressed that the study, published in Nature Communications, is only a small step towards kidney tissue grown from stem cells being used clinically. 'It is not known yet if simply transplanting regenerated cells would really cure kidney ailments', he said.

Dr Takahashi Yokoo, of Jikei University, Tokyo, who was not involved with the study, agreed, telling AFP: 'Yes, a tubule structure was generated, but an enormous amount of research is still necessary to create an orderly structure that produces urine'.

Nonetheless, Dr Osafune said that his team had taken 'the preliminary step on the road to the clinical level'.


02 September 2013 - by Dr Sophie Pryor 
Human stem cells have been used to grow miniature brains, 'organoids' that are just millimetres across and at an equivalent developmental stage as in a nine-week-old fetus...
07 May 2013 - by David O'Rourke 
A toddler has become the youngest person to receive a bioengineered organ, receiving a life-saving windpipe transplant made from her own stem cells...
11 February 2013 - by Richard Fadok 
Brain cells engineered from human skin tissue have successfully treated laboratory mice with a deadly nerve disorder with similarities to multiple sclerosis...
04 February 2013 - by Reuben Harwood 
Aged stem cells can be returned to a younger, more active state by increasing the activity of a single gene...

17 December 2012 - by Alison Cranage 
Scientists have converted kidney cells from human urine into brain cells, bypassing the need for embryonic stem cells...
12 March 2012 - by Dr Rebecca Robey 
Stem cell therapy may remove the need for organ transplant recipients to have lifelong drug treatment to combat the risk of rejection, which would dramatically improve patients' quality of life...
18 April 2011 - by Dr Rosie Gilchrist 
Scientists at Edinburgh University have grown kidney structures in the laboratory in a step they hope will lead to organs being grown for transplant patients from their own stem cells...
21 June 2010 - by Dr Nadeem Shaikh 
A woman has died after receiving stem cell therapy to treat a kidney ailment at a private clinic in Thailand....

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